Results 71 to 80 of about 53,760 (217)

Protein crotonylation sensitizes SMACm disruption of latent HIV by modulating the ncNF-κB signaling pathway at the step of p100 cleavage into p52

Journal of Virus Eradication, 2019
J. Guochun, D. Li, S. Falcinelli, L. Wong, C. Garrido, C. Galardi, R. Dunham, E. Brown, N. Archin, D. Margolis   +9 more
doaj   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

O2 Cross-validation of HIV DNA assays to quantify different HIV-1 subtypes by ddPCR

Journal of Virus Eradication, 2016
S. Rutsaert, W. Trypsteen, C. Van Hecke, M.A. De Scheerder, M. Kiselinova, K. Vervisch, W. De Spiegelaere, L. Vandekerckhove   +7 more
doaj   +1 more source

Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy

eLife
Understanding the interplay between the HIV reservoir and the host immune system may yield insights into HIV persistence during antiretroviral therapy (ART) and inform strategies for a cure.
Lesia Semenova, Yingfan Wang, Shane Falcinelli, Nancie Archin, Alicia D Cooper-Volkheimer, David M Margolis, Nilu Goonetilleke, David M Murdoch, Cynthia D Rudin, Edward P Browne   +9 more
doaj   +1 more source

B/ordering and healthcare access for migrants with precarious status: The role of healthcare workers in counteracting restrictive policies

American Journal of Community Psychology, EarlyView.
Abstract In Canada, precarious migration is largely invisibilized. Nonetheless, b/ordering greatly affects people's realities by limiting access to social rights. In Quebec, migrants with precarious status (MPS) do not have access to healthcare, although Quebec has a “universal” healthcare coverage.
Émilie Pigeon‐Gagné, Jill Hanley, Élise Bourgeois‐Guérin, Pénélope Boudreault   +3 more
wiley   +1 more source

Combinatorial latency reversal activity of inhibitor of apoptosis antagonists with mechanistically distinct classes of HIV latency reversal agents

Journal of Virus Eradication, 2019
Shane D. Falcinelli, David M. Irlbeck, Anne-Marie Turner, Frances Potjewyd, Lindsey I. James, David M. Margolis, Nancie M. Archin, Richard M. Dunham   +7 more
doaj   +1 more source

Immigration detention centers as torturing environments: Ethical reckonings, radical refusals, and implications for a psychology of resistance

American Journal of Community Psychology, EarlyView.
Abstract This paper examines psychologists' ethical dilemmas in immigration detention centers. Using critical psychology, border, and detention scholarship, it highlights psychologists' historical complicity in state violence, from the U.S. Enhanced Interrogation Program to current border regimes.
Francesca Esposito, Federica de Cordova, Julia Manek, Sara Buckingham, Camilla Ponti, Francesco Tommasi, Bradley Olson   +6 more
wiley   +1 more source

Exploring sequence specific silencing of latent HIV using CRISPR interference

Journal of Virus Eradication, 2019
R. Schwarzer, M. Montano, W.C. Greene
doaj   +1 more source

OP 1.4 – 00053 Definitive evidence of a persistent HIV reservoir in human brain myeloid cells despite ART

Journal of Virus Eradication, 2022
Y. Tang, G. Jiang, M. Porrachia, C. Ignacio, L.M. Wong, D. Zhong, J. Du, B. Cotsakis, S. Maske, E. de la Parra Polina, T.L. Simermeyer, D. Li, B. Woodworth, J. Kirchherr, B. Allard, M. Clohosey, G.D. Whitehill, J.J. Eron, N.M. Archin, S.B. Joseph, K. Bar, A. Chaillon, S. Gianella, D.M. Margolis, G. Jiang   +24 more
doaj   +1 more source

Development and Evaluation of a Novel Relatively Low-Cost Method to Derive HIV-1 Integration Sites and Proviral Sequences

Viruses
In people taking antiretroviral therapy (ART) for HIV infection, the methods to characterize latent and active HIV reservoirs remain costly and labor-intensive.
Samantha R. Hardy, Sheila Styrchak, Tim De Meyer, Laurens Lambrechts, Tine Struyve, Basiel Cole, Liesbet Termote, Sherry McLaughlin, James I. Mullins, Linos Vandekerckhove, Lisa M. Frenkel   +10 more
doaj   +1 more source