Results 81 to 90 of about 58,279 (299)

Is it possible to cure HIV infection? [PDF]

, 2020
Antiretroviral therapy has significantly improved the life expectancy in HIV-infected people, but it cannot cure the disease by itself. Several barriers have been identified for the cure of HIV infection, including a reservoir of latently infected cells,
Moreno, S., Gutiérrez, C., Madrid, N. P.   +2 more
core  

Blood and tissue HIV-1 reservoirs display plasticity and lack of compartmentalization in virally suppressed people

Nature Communications
Characterizing the HIV-1 reservoir in blood and tissues is crucial for the development of curative strategies. Using an HIV Tat mRNA-containing lipid nanoparticle (Tat-LNP) in combination with panobinostat, we show that p24+ cells from blood and lymph ...
Marion Pardons, Laurens Lambrechts, Ytse Noppe, Liesbet Termote, Sofie De Braekeleer, Jerel Vega, Ellen Van Gulck, Sarah Gerlo, Linos Vandekerckhove   +8 more
doaj   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Labs During Methotrexate Therapy

Arthritis Care &Research, Accepted Article.
Objective To evaluate whether extending the American College of Rheumatology (ACR)–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

PP 1.23 – 00130 Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Journal of Virus Eradication, 2022
L. Lambrechts, R. Verstraeten, N. Bonine, Y. Noppe, S. Rutsaert, M. Pardons, B. Cole, L. Vandekerckhove   +7 more
doaj   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Ribavirin Concentrations Do Not Predict Sustained Virological Response in HIV/HCV-Coinfected Patients Treated with Ribavirin and Pegylated Interferon in the Swiss HIV Cohort Study. [PDF]

, 2015
BACKGROUND Ribavirin (RBV) is an essential component of most current hepatitis C (HCV) treatment regimens and still standard of care in the combination with pegylated interferon (pegIFN) to treat chronic HCV in resource limited settings. Study results
Ambrosioni, Juan, Daniel Müller, Enos Bernasconi, Stöckle, M., Stöckle, Marcel, Cavassini, M., Bregenzer, Andrea, Velli, P., Müller, D., Rotger, Margalida, Marcel Stöckle, Bregenzer, A., Rauch, A., Pablo Velli, Russmann, S., Ledergerber, B., Andrea Bregenzer, Kovari, H., Bernasconi, Enos, Swiss HIV Cohort Study, Rotger, M., Juan Ambrosioni, Andri Rauch, Velli, Pablo, Rauch, Andri, Helen Kovari, Kovari, Helen, Bruno Ledergerber, Ledergerber, Bruno, Müller, Daniel, Ambrosioni, J., Roberto F Speck, Russmann, Stefan, Speck, Roberto F, Stefan Russmann, Margalida Rotger, Speck, R.F., Cavassini, Matthias, Matthias Cavassini, Bernasconi, E.   +39 more
core   +1 more source

Microneedles Mediated Delivery of Nanodiamonds for Quantum Sensing of Free Radicals in Skin Tissue

Advanced Materials Technologies, EarlyView.
Fluorescent nanodiamonds are nanoscale sensors capable of monitoring cellular stress responses. However, to function effectively, they must be delivered into cells or tissues. Here, we demonstrate their application in the skin by developing a dissolvable microneedle platform that dissolves after skin insertion, enabling the delivery of nanodiamonds ...
Siyu Fan, Maria Carmona Lobita, Thea Vedelaar, Yue Zhang, Claudia Reyes‐San‐Martin, Tomás Bauleth‐Ramos, Gésinda Geertsema‐Doornbusch, Han Gao, Mohammad‐Ali Shahbazi, Hélder A. Santos, Romana Schirhagl   +10 more
wiley   +1 more source

Deep latency: A new insight into a functional HIV cure

EBioMedicine, 2019
Latent HIV reservoir is the main obstacle that prevents a cure for HIV-1 (HIV). While antiretroviral therapy is effective in controlling viral replication, it cannot eliminate latent HIV reservoirs in patients.
Maher M. Elsheikh, Yuyang Tang, Dajiang Li, Guochun Jiang   +3 more
doaj   +1 more source

A cure for HIV: is it in sight?

Expert Review of Anti-infective Therapy, 2014
HIV is a devastating disease affecting millions of people worldwide despite the advent of successful antiretroviral therapy (ART). However, ART does not result in a cure and has to be taken for life. Accordingly, researchers are turning towards cure efforts, particularly in the light of two patients whose HIV has been seemingly eradicated.
Pace, M, Frater, J
openaire   +3 more sources