Results 91 to 100 of about 53,760 (217)

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

O5 The expression profile of host restriction factors in different cohorts of HIV-1-infected patients

Journal of Virus Eradication, 2017
C. Van Hecke, E. Malatinkova, W. De Spiegelaere, M. Sips, K. Vervisch, C. Verhofstede, M. Johnson, S. Kinloch-de Loës, W. Trypsteen, L. Vandekerckhove   +9 more
doaj   +1 more source

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Synergistic HIV latency reversal from an in vitro screen of epigenetic and kinase inhibitors

Journal of Virus Eradication, 2017
D. Irlbeck, Y. Zhao, A. Axtman, B. Zuercher, L. Ingerman-James   +4 more
doaj   +1 more source

PP 1.4 – 00037 Histone decrotonylation uniquely regulates HIV-1 transcription and can be modulated to control HIV-1 latency

Journal of Virus Eradication, 2022
T.L. Simermeyer, D. Li, L.M. Wong, C. Aquino, Y. Tang, E.P. Browne, N.M. Archin, D.M. Margolis, G. Jiang   +8 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

HIV cure after HCT: 7 horses seem to be on the mark. [PDF]

Blood Adv
Camargo JF.
europepmc   +1 more source

British National Formulary Guidance on prescribing in pregnancy: A descriptive cross‐sectional study

British Journal of Clinical Pharmacology, EarlyView.
Aim To assess how well pregnancy‐specific guidance within the British National Formulary supports healthcare professionals to facilitate safe and effective medication use. Methods We performed a manifest content analysis of the text of all pregnancy sections within British National Formulary drug monographs, with inductive and iterative coding.
Hannah Johnson, Cleodie Swire, Lakshiv Dhingra, Toqa El‐Nahhas, Michelle Essiam, Salma Muse, Maria Tonkova, Nazmin Begum, Joan Morris, Emma Baker   +9 more
wiley   +1 more source

Ethical frameworks and community engagement in HIV cure-related research at the end of life: looking back, moving forward. [PDF]

Curr Opin HIV AIDS
Ahmed A, Tran W, Ndukwe S, Sloane Z, Costiniuk C, Dubé K.   +5 more
europepmc   +1 more source

Natural killer cells in pediatric HIV cure strategies: from viral control to immunotherapeutics. [PDF]

Curr Opin HIV AIDS
Cotugno N, de Armas L, Palma P.
europepmc   +1 more source