Results 1 to 10 of about 35,436 (198)

HIV reservoirs and latency models

Virology, 2011
The main impediment to a cure for HIV is the existence of long-lasting treatment resistant viral reservoirs. In this review, we discuss what is currently known about reservoirs, including their formation and maintenance, while focusing on latently infected CD4+ T cells.
Pace, Matthew J., Agosto, Luis, Graf, Erin H., O'Doherty, Una   +3 more
openaire   +2 more sources

Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy

eLife
Understanding the interplay between the HIV reservoir and the host immune system may yield insights into HIV persistence during antiretroviral therapy (ART) and inform strategies for a cure.
Lesia Semenova, Yingfan Wang, Shane Falcinelli, Nancie Archin, Alicia D Cooper-Volkheimer, David M Margolis, Nilu Goonetilleke, David M Murdoch, Cynthia D Rudin, Edward P Browne   +9 more
doaj   +1 more source

Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review

Frontiers in Immunology, 2021
Despite the benefits achieved by the widespread availability of modern antiretroviral therapy (ART), HIV RNA integration into the host cell genome is responsible for the creation of latent HIV reservoirs, and represents a significant impediment to ...
Silvere D. Zaongo, Feng Sun, Yaokai Chen
doaj   +1 more source

Retinoids: novel potential therapeutics in the pursuit of HIV-1 cure

Frontiers in Virology, 2022
Human immunodeficiency virus (HIV) infection remains a global epidemic. While antiretroviral therapy (ART) suppresses viral replication, cessation of ART results in viral rebound necessitating lifelong treatment.
Andrew Purssell, Michaeline McGuinty, Michaeline McGuinty, Branka Vulesevic, Jonathan B. Angel, Jonathan B. Angel   +5 more
doaj   +1 more source

Inducible HIV-1 Reservoir Reduction Assay (HIVRRA), a Fast and Sensitive Assay to Test Cytotoxicity and Potency of Cure Strategies to Reduce the Replication-Competent HIV-1 Reservoir in Ex Vivo PBMCs

Bio-Protocol
The HIV-1 reservoir, consisting of transcriptionally silent integrated HIV-1 proviruses, is a major barrier to a cure, as it persists during effective antiretroviral therapy (ART) and is the source of viral rebound upon treatment interruption.
Jade Jansen, Teunis Geijtenbeek, Neeltje Kootstra   +2 more
doaj   +1 more source

Nanotechnology approaches to eradicating HIV reservoirs [PDF]

European Journal of Pharmaceutics and Biopharmaceutics, 2019
The advent of combination antiretroviral therapy (cART) has transformed HIV-1 infection into a controllable chronic disease, but these therapies are incapable of eradicating the virus to bring about an HIV cure. Multiple strategies have been proposed and investigated to eradicate latent viral reservoirs from various biological sanctuaries. However, due
Shijie Cao, Kim A. Woodrow
openaire   +2 more sources

Advances in the mechanism of regulatory T cells in human immunodeficiency virus infection

Guangxi Yike Daxue xuebao
Regulatory T cells (Tregs) are not only the target cells of human immunodeficiency virus (HIV) infection, but also critical mediators of immunosuppression and immune regulation.
YU Minrui, JIAO Yanmei, WANG Fusheng
doaj   +1 more source

The HIV Reservoir in Monocytes and Macrophages

Frontiers in Immunology, 2019
In people living with HIV (PLWH) who are failing or unable to access combination antiretroviral therapy (cART), monocytes and macrophages are important drivers of pathogenesis and progression to AIDS. The relevance of the monocyte/macrophage reservoir in PLWH receiving cART is debatable as in vivo evidence for infected cells is limited and suggests the
Michelle E. Wong, Michelle E. Wong, Anthony Jaworowski, Anthony Jaworowski, Anna C. Hearps, Anna C. Hearps   +5 more
openaire   +3 more sources

Re-evaluating evolution in the HIV reservoir [PDF]

Nature, 2017
Despite antiretroviral therapy (ART), a latent reservoir of replication-competent HIV-1 persists in resting memory CD4 + T-cells and precludes cure 1-6 . Lorenzo-Redondo et al .
Rosenbloom, Daniel I. S., Hill, Alison L., Laskey, Sarah B., Siliciano, Robert F.   +3 more
openaire   +2 more sources

Atlas of the HIV-1 Reservoir in Peripheral CD4 T Cells of Individuals on Successful Antiretroviral Therapy

mBio, 2021
Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations from 14 HIV-1 ...
Cristina Gálvez, Judith Grau-Expósito, Victor Urrea, Bonaventura Clotet, Vicenç Falcó, Maria José Buzón, Javier Martinez-Picado   +6 more
doaj   +1 more source