Results 31 to 40 of about 35,308 (213)

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Nanotechnology approaches to eradicating HIV reservoirs [PDF]

European Journal of Pharmaceutics and Biopharmaceutics, 2019
The advent of combination antiretroviral therapy (cART) has transformed HIV-1 infection into a controllable chronic disease, but these therapies are incapable of eradicating the virus to bring about an HIV cure. Multiple strategies have been proposed and investigated to eradicate latent viral reservoirs from various biological sanctuaries. However, due
Shijie Cao, Kim A. Woodrow
openaire   +2 more sources

Inducible HIV-1 Reservoir Reduction Assay (HIVRRA), a Fast and Sensitive Assay to Test Cytotoxicity and Potency of Cure Strategies to Reduce the Replication-Competent HIV-1 Reservoir in Ex Vivo PBMCs

Bio-Protocol
The HIV-1 reservoir, consisting of transcriptionally silent integrated HIV-1 proviruses, is a major barrier to a cure, as it persists during effective antiretroviral therapy (ART) and is the source of viral rebound upon treatment interruption.
Jade Jansen, Teunis Geijtenbeek, Neeltje Kootstra   +2 more
doaj   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

The HIV Reservoir in Monocytes and Macrophages

Frontiers in Immunology, 2019
In people living with HIV (PLWH) who are failing or unable to access combination antiretroviral therapy (cART), monocytes and macrophages are important drivers of pathogenesis and progression to AIDS. The relevance of the monocyte/macrophage reservoir in PLWH receiving cART is debatable as in vivo evidence for infected cells is limited and suggests the
Michelle E. Wong, Michelle E. Wong, Anthony Jaworowski, Anthony Jaworowski, Anna C. Hearps, Anna C. Hearps   +5 more
openaire   +3 more sources

Re-evaluating evolution in the HIV reservoir [PDF]

Nature, 2017
Despite antiretroviral therapy (ART), a latent reservoir of replication-competent HIV-1 persists in resting memory CD4 + T-cells and precludes cure 1-6 . Lorenzo-Redondo et al .
Rosenbloom, Daniel I. S., Hill, Alison L., Laskey, Sarah B., Siliciano, Robert F.   +3 more
openaire   +2 more sources

Advances in the mechanism of regulatory T cells in human immunodeficiency virus infection

Guangxi Yike Daxue xuebao
Regulatory T cells (Tregs) are not only the target cells of human immunodeficiency virus (HIV) infection, but also critical mediators of immunosuppression and immune regulation.
YU Minrui, JIAO Yanmei, WANG Fusheng
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Biomarker reveals HIV's hidden reservoir [PDF]

eLife, 2014
Determining the total amount of HIV DNA in people undergoing antiretroviral therapy could accelerate the development of novel therapies and potential cures for HIV infection.
Leslie R Cockerham, Steven G Deeks
openaire   +4 more sources

Factors Associated with the Size of HIV DNA Reservoir

Chinese Medical Journal, 2017
Objective: To review the recent literatures related to the factors associated with the size of the HIV reservoir and their clinical significance. Data Sources: Literatures related to the size of HIV DNA was collected from PubMed published from 1999 to ...
Ni-Dan Wang, Tai-Sheng Li
doaj   +1 more source