Results 31 to 40 of about 35,436 (198)
Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays
Viruses, 2022 Significant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment (ART)-free remission and cure for persons living with HIV-1 are being made with the advent of broadly neutralizing antibodies and very early ART in perinatal ...
Priya Khetan +3 more
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HIV in the Brain: Identifying Viral Reservoirs and Addressing the Challenges of an HIV Cure
Vaccines, 2021 Advances in antiretroviral therapy have prolonged the life of people living with HIV and diminished the level of virus in these individuals. Yet, HIV quickly rebounds after disruption and/or cessation of treatment due to significant cellular and ...
Michelle K. Ash +2 more
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Engineering CAR T Cells to Target the HIV Reservoir
Frontiers in Cellular and Infection Microbiology, 2020 The HIV reservoir remains to be a difficult barrier to overcome in order to achieve a therapeutic cure for HIV. Several strategies have been developed to purge the reservoir, including the “kick and kill” approach, which is based on the notion that ...
Wenli Mu +2 more
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Predicting Post-treatment HIV Remission: Does Size of the Viral Reservoir Matter?
Frontiers in Microbiology, 2021 Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) replication and improves immune function. However, due to the persistence of long-lived HIV reservoirs, therapy interruption almost inevitably leads to a fast viral ...
Alexander O. Pasternak +2 more
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Retrovirology, 2007 Background The presence of HIV-1 preintegration reservoir was assessed in an in vitro experimental model of latent HIV-1 infection, and in patients treated or not with highly active antiretroviral therapy (HAART).
Baillat Vincent +7 more
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HIV Reservoir Characterization Symposium
Journal of Virus Eradication, 2017 The HIV Cure Research Center (HCRC) in Ghent organised the first HIV Reservoir Characterization Symposium, and brought together virologists, molecular biologists, immunologists and clinicians to discuss the most recent developments in HIV reservoir ...
Eva Malatinkova +3 more
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Barriers for HIV Cure: The Latent Reservoir [PDF]
AIDS Research and Human Retroviruses, 2018 Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in search of vaccines and treatments to eradicate this devastating infectious disease. Progress has been made in understanding the molecular pathogenesis of this infection, which has been crucial for the development of the current therapy regimens. However,
Castro-Gonzalez, Sergio +2 more
openaire +4 more sources
Journal of Virus Eradication, 2022 The HIV reservoir is a population of 1–10 million anatomically dispersed, latently infected memory CD4+ T cells in which HIV DNA is quiescently integrated into human chromosomal DNA.
Florencia A. Tettamanti Boshier +6 more
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Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy. [PDF]
PLoS ONE, 2016 A major challenge to HIV eradication strategies is the lack of an accurate measurement of the total burden of replication-competent HIV (the "reservoir").
Sulggi A Lee +11 more
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Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA
Frontiers in Microbiology, 2021 The presence of a stable HIV-1 reservoir persisting over time despite effective antiretroviral suppression therapy precludes a cure for HIV-1. Characterizing and quantifying this residual reservoir is considered an essential prerequisite to develop and ...
Cynthia Lungu +3 more
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