High heritability is compatible with the broad distribution of set point viral load in HIV carriers. [PDF]
PLoS Pathogens, 2015 Set point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors ...
Sebastian Bonhoeffer +2 more
doaj +13 more sources
Association between Epstein–Barr viral load and duration of hospitalization in pediatric infectious mononucleosis: a single-center retrospective study [PDF]
Frontiers in MedicineBackgroundEpstein–Barr virus (EBV) infection exhibits considerable heterogeneity in clinical manifestations among children, ranging from self-limiting symptoms to severe complications.
Zhi Yang +4 more
doaj +2 more sources
How Can Viral Dynamics Models Inform Endpoint Measures in Clinical Trials of Therapies for Acute Viral Infections? [PDF]
, 2016 Acute viral infections pose many practical challenges for the accurate assessment of the impact of novel therapies on viral growth and decay. Using the example of influenza A, we illustrate how the measurement of infection-related quantities that ...
Anderson, RM +6 more
core +23 more sources
Zhongguo gonggong weisheng, 2022 ObjectiveTo explore an optimal alternative index of population viral load (PVL) suitable for assessing potential human immunodeficiency virus (HIV) transmission in the population of Yining city, Xinjiang Uygur Autonomous Region.
Qian HE +2 more
doaj +1 more source
SARS-CoV-2 Viral Load Is Correlated With the Disease Severity and Mortality in Patients With Cancer
Frontiers in Oncology, 2021 The correlation between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viral load and risk of disease severity in cancer patients is poorly understood.
Maha Al-Mozaini +8 more
doaj +1 more source
PLOS Global Public Health, 2023 Uganda applies the World Health Organization threshold of 1,000 copies/ml to determine HIV viral non-suppression. While there is an emerging concern of low-level viraemia (≥50 to
Nicholus Nanyeenya +9 more
doaj +1 more source
Near point-of-care HIV viral load testing: Cascade after high viral load in suburban Yangon, Myanmar
PLoS ONE, 2023 Introduction HIV viral load (VL) testing in resource-limited settings is often centralised, limiting access. In Myanmar, we assessed outcomes according to VL access and the VL cascade (case management after a first high VL result) before and after near ...
Ni Ni Tun +7 more
doaj +2 more sources
Research progress on anti-viral treatment for chronic hepatitis B patients with high viral load [PDF]
Xin yixue, 2022 Chronic hepatitis B （CHB） is a severe disease that affects human health. Replication of hepatitis B virus （HBV） is the main cause of morbidity in CHB patients.
Peng Wan, Cao Hong
doaj +1 more source
AIDS Research and Therapy, 2023 Background Intensive adherence counseling (IAC) is the global standard of care for people living with human immunodeficiency virus (PLHIV) who have unsuppressed VL after ≥ 6 months of first-line anti-retroviral therapy (ART).
Jonathan Izudi +3 more
doaj +1 more source
Modelling upper respiratory viral load dynamics of SARS-CoV-2
BMC Medicine, 2022 Relationships between viral load, severity of illness, and transmissibility of virus are fundamental to understanding pathogenesis and devising better therapeutic and prevention strategies for COVID-19. Here we present within-host modelling of viral load
Joseph D. Challenger +8 more
doaj +1 more source