Results 1 to 10 of about 844,830 (315)

The direct and indirect drivers shaping RNA viral communities in grassland soils [PDF]

mSystems
Recent studies have revealed diverse RNA viral communities in soils. Yet, how environmental factors influence soil RNA viruses remains largely unknown. Here, we recovered RNA viral communities from bulk metatranscriptomes sequenced from grassland soils ...
Ruonan Wu, Amy E. Zimmerman, Kirsten S. Hofmockel   +2 more
doaj   +2 more sources

RNA modifications go viral. [PDF]

PLoS Pathogens, 2017
Nandan S Gokhale, Stacy M Horner
doaj   +4 more sources

Amuvatinib Blocks SARS-CoV-2 Infection at the Entry Step of the Viral Life Cycle

Microbiology Spectrum, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). SARS-CoV-2 propagation is mediated by the protein interaction between viral proteins and host cells.
Trang T. X. Huynh, Thuy X. Pham, Gun-Hee Lee, Jae-Bong Lee, Sung-Geun Lee, Dongseob Tark, Yun-Sook Lim, Soon B. Hwang   +7 more
doaj   +1 more source

A natural product YSK-A blocks SARS-CoV-2 propagation by targeting multiple host genes

Scientific Reports, 2023
Natural products and herbal medicine have been widely used in drug discovery for treating infectious diseases. Recent outbreak of COVID-19 requires various therapeutic strategies.
Thuy X. Pham, Trang T. X. Huynh, Bumseok Kim, Yun-Sook Lim, Soon B. Hwang   +4 more
doaj   +1 more source

Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts

Nature Communications, 2021
Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally ...
Veronica V. Rezelj, Lucía Carrau, Fernando Merwaiss, Laura I. Levi, Diana Erazo, Quang Dinh Tran, Annabelle Henrion-Lacritick, Valérie Gausson, Yasutsugu Suzuki, Djoshkun Shengjuler, Bjoern Meyer, Thomas Vallet, James Weger-Lucarelli, Veronika Bernhauerová, Avi Titievsky, Vadim Sharov, Stefano Pietropaoli, Marco A. Diaz-Salinas, Vincent Legros, Nathalie Pardigon, Giovanna Barba-Spaeth, Leonid Brodsky, Maria-Carla Saleh, Marco Vignuzzi   +23 more
doaj   +1 more source

RNA Interference for Viral Infections [PDF]

Current Drug Targets, 2012
The treatment of viral infections has relied on pre-emptive vaccination or use of a limited range of anti-viral drugs. However, the majority of viruses have no available drugs and treatment is merely supportive. RNA interference (RNAi) offers the ability to directly and rapidly treat virus infections via the targeting of viral genes.
Blake, Stephen J., Bokhari, Fawzi F., McMillan, Nigel A. J.   +2 more
openaire   +5 more sources

Reovirus Low-Density Particles Package Cellular RNA

Viruses, 2021
Packaging of segmented, double-stranded RNA viral genomes requires coordination of viral proteins and RNA segments. For mammalian orthoreovirus (reovirus), evidence suggests either all ten or zero viral RNA segments are simultaneously packaged in a ...
Timothy W. Thoner, Xiang Ye, John Karijolich, Kristen M. Ogden   +3 more
doaj   +1 more source

A viral deubiquitylating enzyme targets viral RNA‐dependent RNA polymerase and affects viral infectivity [PDF]

The EMBO Journal, 2011
Selective protein degradation via the ubiquitin-proteasome system (UPS) plays an essential role in many major cellular processes, including host-pathogen interactions. We previously reported that the tightly regulated viral RNA-dependent RNA polymerase (RdRp) of the positive-strand RNA virus Turnip yellow mosaic virus (TYMV) is degraded by the UPS in ...
Chenon, Mélanie, Camborde, Laurent, Cheminant, Soizic, Jupin, Isabelle   +3 more
openaire   +2 more sources

Poly(rC)-Binding Protein 1 Limits Hepatitis C Virus Virion Assembly and Secretion

Viruses, 2022
The hepatitis C virus (HCV) co-opts numerous cellular elements, including proteins, lipids, and microRNAs, to complete its viral life cycle. The cellular RNA-binding protein, poly(rC)-binding protein 1 (PCBP1), was previously reported to bind to the 5 ...
Sophie E. Cousineau, Marylin Rheault, Selena M. Sagan   +2 more
doaj   +1 more source

Viral sensing by RNA helicases

Virologie, 2020
A key aspect of antiviral immunity is the distinction between "self" and "non-self" components. This distinction can be established through the detection of double-stranded RNA (dsRNA), a common sign of viral infection, by cytosolic RNA helicases.
Rousseau, Claire, Meignin, Carine
openaire   +4 more sources