Results 1 to 10 of about 2,102,458 (307)

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

Critical Care, 2020
Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus.
Jesús F. Bermejo-Martin, Milagros González-Rivera, Raquel Almansa, Dariela Micheloud, Ana P. Tedim, Marta Domínguez-Gil, Salvador Resino, Marta Martín-Fernández, Pablo Ryan Murua, Felipe Pérez-García, Luis Tamayo, Raúl Lopez-Izquierdo, Elena Bustamante, César Aldecoa, José Manuel Gómez, Jesús Rico-Feijoo, Antonio Orduña, Raúl Méndez, Isabel Fernández Natal, Gregoria Megías, Montserrat González-Estecha, Demetrio Carriedo, Cristina Doncel, Noelia Jorge, Alicia Ortega, Amanda de la Fuente, Félix del Campo, José Antonio Fernández-Ratero, Wysali Trapiello, Paula González-Jiménez, Guadalupe Ruiz, Alyson A. Kelvin, Ali Toloue Ostadgavahi, Ruth Oneizat, Luz María Ruiz, Iria Miguéns, Esther Gargallo, Ioana Muñoz, Sara Pelegrin, Silvia Martín, Pablo García Olivares, Jamil Antonio Cedeño, Tomás Ruiz Albi, Carolina Puertas, Jose Ángel Berezo, Gloria Renedo, Rubén Herrán, Juan Bustamante-Munguira, Pedro Enríquez, Ramón Cicuendez, Jesús Blanco, Jesica Abadia, Julia Gómez Barquero, Nuria Mamolar, Natalia Blanca-López, Luis Jorge Valdivia, Belén Fernández Caso, María Ángeles Mantecón, Anna Motos, Laia Fernandez-Barat, Ricard Ferrer, Ferrán Barbé, Antoni Torres, Rosario Menéndez, José María Eiros, David J. Kelvin   +65 more
doaj   +1 more source

Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles

mBio, 2021
The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication
Christopher H. Lee, Krishnan Raghunathan, Gwen M. Taylor, Andrea J. French, Raquel Tenorio, Isabel Fernández de Castro, Cristina Risco, John S. L. Parker, Terence S. Dermody   +8 more
doaj   +1 more source

Viral RNAs Are Unusually Compact

PLoS ONE, 2014
A majority of viruses are composed of long single-stranded genomic RNA molecules encapsulated by protein shells with diameters of just a few tens of nanometers. We examine the extent to which these viral RNAs have evolved to be physically compact molecules to facilitate encapsulation. Measurements of equal-length viral, non-viral, coding and non-coding
Gopal, Ajaykumar, Egecioglu, Defne E, Yoffe, Aron M, Ben-Shaul, Avinoam, Rao, Ayala LN, Knobler, Charles M, Gelbart, William M   +6 more
openaire   +6 more sources

Icosahedral Packing of RNA Viral Genomes [PDF]

Physical Review Letters, 2005
4 pages revtex, 4 eps ...
Rudnick, Joseph, Bruinsma, Robijn
openaire   +3 more sources

Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus

Nature Communications
Zika virus (ZIKV) is a mosquito-borne orthoflavivirus primarily transmitted among humans by Aedes aegypti. Over the past two decades, it has caused significant outbreaks associated with birth defects and neurological disorders.
Shiho Torii, Jennifer S. Lord, Morgane Lavina, Matthieu Prot, Alicia Lecuyer, Cheikh T. Diagne, Oumar Faye, Ousmane Faye, Amadou A. Sall, Michael B. Bonsall, Etienne Simon-Lorière, Xavier Montagutelli, Louis Lambrechts   +12 more
doaj   +1 more source

Long-distance RNA–RNA interactions shape dynamic RNA architectures and functional states in plant positive-strand RNA viruses

Frontiers in Microbiology
The genomes of positive-strand RNA [(+)ssRNA] viruses function as dynamic RNA molecules that participate in multiple, sometimes competing, processes during infection, including translation, genome replication, subgenomic RNA (sgRNA) transcription, and ...
Deya Wang, Haoran Wu, Xianping Zhang, Qingle Chang, Xuefeng Yuan   +4 more
doaj   +1 more source

Host and viral RNA-binding proteins involved in membrane targeting, replication and intercellular movement of plant RNA virus genomes

Frontiers in Plant Science, 2014
Many plant viruses have positive-strand RNA [(+)RNA] as their genome. Therefore, it is not surprising that RNA-binding proteins (RBPs) play important roles during (+)RNA virus infection in host plants.
Kiwamu eHyodo, Masanori eKaido, Tetsuro eOkuno   +2 more
doaj   +1 more source

Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicase.

PLoS ONE, 2012
The flavivirus nonstructural protein 3 (NS3) bears multiple enzymatic activities and represents an attractive target for antiviral intervention. NS3 contains the viral serine protease at the N-terminus and ATPase, RTPase, and helicase activities at the C-
Leopoldo G Gebhard, Sergio B Kaufman, Andrea V Gamarnik   +2 more
doaj   +1 more source

Initiation of viral RNA-dependent RNA polymerization

Journal of General Virology, 2004
This review summarizes the combined insights from recent structural and functional studies of viral RNA-dependent RNA polymerases (RdRPs) with the primary focus on the mechanisms of initiation of RNA synthesis. Replication of RNA viruses has traditionally been approached using a combination of biochemical and genetic methods.
Alberdina A, van Dijk, Eugene V, Makeyev, Dennis H, Bamford   +2 more
openaire   +2 more sources

N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA

Nature Communications, 2021
N6-methyladenosine (m6A) RNA modification regulates RNA metabolism, and has been implicated in immune regulation. Here, the authors show that the m6A methyltransferase, METTL3, translocates into the cytoplasm to increase viral RNA m6A modification ...
Weinan Qiu, Qingyang Zhang, Rui Zhang, Yangxu Lu, Xin Wang, Huabin Tian, Ying Yang, Zijuan Gu, Yanan Gao, Xin Yang, Guanshen Cui, Baofa Sun, Yanan Peng, Hongyu Deng, Hua Peng, Angang Yang, Yun-Gui Yang, Pengyuan Yang   +17 more
doaj   +1 more source