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VirBot: an RNA viral contig detector for metagenomic data. [PDF]
Bioinformatics, 2023 Summary Without relying on cultivation, metagenomic sequencing greatly accelerated the novel RNA virus detection. However, it is not trivial to accurately identify RNA viral contigs from a mixture of species. The low content of RNA viruses in metagenomic
Chen G, Tang X, Shi M, Sun Y.
europepmc +2 more sources
From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution [PDF]
Cells, 2021 The current SARS-CoV-2 pandemic underscores the importance of understanding the evolution of RNA genomes. While RNA is subject to the formation of similar lesions as DNA, the evolutionary and physiological impacts RNA lesions have on viral genomes are ...
Kockler ZW, Gordenin DA.
europepmc +3 more sources
VGEA: an RNA viral assembly toolkit. [PDF]
PeerJ, 2021 Next generation sequencing (NGS)-based studies have vastly increased our understanding of viral diversity. Viral sequence data obtained from NGS experiments are a rich source of information, these data can be used to study their epidemiology, evolution ...
Oluniyi PE +13 more
europepmc +2 more sources
VITAP: a high precision tool for DNA and RNA viral classification based on meta-omic data. [PDF]
Nat CommunThe rapid growth in the number of newly identified DNA and RNA viral sequences underscores the need for an accurate and comprehensive classification system for all viral realms at different taxonomic levels.
Zheng K +6 more
europepmc +2 more sources
Innate immune responses in RNA viral infection. [PDF]
Front Med, 2021 RNA viruses cause a multitude of human diseases, including several pandemic events in the past century. Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating the adaptive immune system.
Xu Q, Tang Y, Huang G.
europepmc +2 more sources
The direct and indirect drivers shaping RNA viral communities in grassland soils [PDF]
mSystemsRecent studies have revealed diverse RNA viral communities in soils. Yet, how environmental factors influence soil RNA viruses remains largely unknown. Here, we recovered RNA viral communities from bulk metatranscriptomes sequenced from grassland soils ...
Ruonan Wu +2 more
doaj +2 more sources
coronaSPAdes: from biosynthetic gene clusters to RNA viral assemblies
bioRxiv, 2020 Motivation The COVID-19 pandemic has ignited a broad scientific interest in viral research in general and coronavirus research in particular. The identification and characterization of viral species in natural reservoirs typically involves de novo ...
Meleshko D +2 more
europepmc +2 more sources
All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes
Frontiers in Immunology, 2020 Interferon (IFN) signaling induces the expression of a wide array of genes, collectively referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication.
Emily Yang +3 more
doaj +2 more sources
Critical Care, 2020 Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus.
Jesús F. Bermejo-Martin +65 more
doaj +2 more sources
Viral RNA structure-based strategies to manipulate translation
Nature Reviews Microbiology, 2018 Viruses must co-opt the cellular translation machinery to produce progeny virions. Eukaryotic viruses have evolved a variety of ways to manipulate the cellular translation apparatus, in many cases using elegant RNA-centred strategies.
Jeffrey S Kieft, Kieft Jeffrey S
exaly +2 more sources