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Microbiology Spectrum, 2016 Acute upper and lower respiratory infections are a major public health problem and a leading cause of morbidity and mortality worldwide. At greatest risk are young children, the elderly, the chronically ill, and those with suppressed or compromised immune systems.
R. Hodinka
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Self-Amplifying RNA Viruses as RNA Vaccines
International Journal of Molecular Sciences, 2020 Single-stranded RNA viruses such as alphaviruses, flaviviruses, measles viruses and rhabdoviruses are characterized by their capacity of highly efficient self-amplification of RNA in host cells, which make them attractive vehicles for vaccine development.
K. Lundstrom
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Self-Replicating RNA Viruses for RNA Therapeutics [PDF]
Molecules, 2018 Self-replicating single-stranded RNA viruses such as alphaviruses, flaviviruses, measles viruses, and rhabdoviruses provide efficient delivery and high-level expression of therapeutic genes due to their high capacity of RNA replication.
Kenneth Lundstrom
doaj +3 more sources
VirSorter2: a multi-classifier, expert-guided approach to detect diverse DNA and RNA viruses
Microbiome, 2021 Viruses are a significant player in many biosphere and human ecosystems, but most signals remain “hidden” in metagenomic/metatranscriptomic sequence datasets due to the lack of universal gene markers, database representatives, and insufficiently advanced
Jiarong Guo +10 more
semanticscholar +1 more source
RNA Structures and Their Role in Selective Genome Packaging
Viruses, 2021 To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs.
Liqing Ye +7 more
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Microorganisms, 2021 Palm Creek virus (PCV) is an insect-specific flavivirus that can interfere with the replication of mosquito-borne flaviviruses in Culex mosquitoes, thereby potentially reducing disease transmission.
Cassandra Koh +3 more
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Hybrids of RNA viruses and viroid-like elements replicate in fungi
Nature Communications, 2023 Earth’s life may have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNA-dependent RNA polymerase
M. Forgia +15 more
semanticscholar +1 more source
Diversity and ecological footprint of Global Ocean RNA viruses
Science, 2022 DNA viruses are increasingly recognized as influencing marine microbes and microbe-mediated biogeochemical cycling. However, little is known about global marine RNA virus diversity, ecology, and ecosystem roles.
Guillermo Domínguez-Huerta +26 more
semanticscholar +1 more source
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses
Science, 2021 An antiviral Dicer defends stem cells Stem cells have a pivotal role in maintaining tissue architecture, integrity, and renewal. Poirier et al.
Enzo Z. Poirier +9 more
semanticscholar +1 more source
Structural insights into RNA polymerases of negative-sense RNA viruses
Nature Reviews Microbiology, 2021 RNA viruses include many important human and animal pathogens, such as the influenza viruses, respiratory syncytial virus, Ebola virus, measles virus and rabies virus.
A. J. T. te Velthuis +2 more
semanticscholar +1 more source