Results 21 to 30 of about 3,436,004 (333)

Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 omicron sub-lineages

iScience, 2023
Summary: The landscape of SARS-CoV-2 variants dramatically diversified with the simultaneous appearance of multiple subvariants originating from BA.2, BA.4, and BA.5 Omicron sub-lineages. They harbor a specific set of mutations in the spike that can make
Franck Touret, Emilie Giraud, Jérôme Bourret, Flora Donati, Jaouen Tran-Rajau, Jeanne Chiaravalli, Frédéric Lemoine, Fabrice Agou, Etienne Simon-Lorière, Sylvie van der Werf, Xavier de Lamballerie   +10 more
doaj   +1 more source

Multifaceted contributions of Dicer2 to arbovirus transmission by Aedes aegypti

Cell Reports, 2023
Summary: Arthropod-borne viruses (arboviruses) transmitted by Aedes aegypti mosquitoes are an increasing threat to global health. The small interfering RNA (siRNA) pathway is considered the main antiviral immune pathway of insects, but its effective ...
Sarah Hélène Merkling, Anna Beth Crist, Annabelle Henrion-Lacritick, Lionel Frangeul, Elodie Couderc, Valérie Gausson, Hervé Blanc, Alexander Bergman, Artem Baidaliuk, Ottavia Romoli, Maria-Carla Saleh, Louis Lambrechts   +11 more
doaj   +1 more source

Force for ancient and recent life: viral and stem-loop RNA consortia promote life. [PDF]

, 2014
Lytic viruses were thought to kill the most numerous host (i.e., kill the winner). But persisting viruses/defectives can also protect against viruses, especially in a ubiquitous virosphere. In 1991, Yarmolinsky et al.
Villarreal, Luis P
core   +1 more source

Doubling of the known set of RNA viruses by metagenomic analysis of an aquatic virome

Nature Microbiology, 2020
RNA viruses in aquatic environments remain poorly studied. Here, we analysed the RNA virome from approximately 10 l water from Yangshan Deep-Water Harbour near the Yangtze River estuary in China and identified more than 4,500 distinct RNA viruses ...
Y. Wolf, Sukrit Silas, Yongjie Wang, Shu-Yin. Wu, M. Bocek, Darius Kazlauskas, M. Krupovic, A. Fire, V. Dolja, E. Koonin   +9 more
semanticscholar   +1 more source

Intranasal immunization with avian paramyxovirus type 3 expressing SARS-CoV-2 spike protein protects hamsters against SARS-CoV-2

npj Vaccines, 2022
Current vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are administered parenterally and appear to be more protective in the lower versus the upper respiratory tract.
Hong-Su Park, Yumiko Matsuoka, Cindy Luongo, Lijuan Yang, Celia Santos, Xueqiao Liu, Laura R. H. Ahlers, Ian N. Moore, Sharmin Afroz, Reed F. Johnson, Bernard A. P. Lafont, David W. Dorward, Elizabeth R. Fischer, Craig Martens, Siba K. Samal, Shirin Munir, Ursula J. Buchholz, Cyril Le Nouën   +17 more
doaj   +1 more source

Ribosomal RNA (rRNA) sequences from 33 globally distributed mosquito species for improved metagenomics and species identification

eLife, 2023
Total RNA sequencing (RNA-seq) is an important tool in the study of mosquitoes and the RNA viruses they vector as it allows assessment of both host and viral RNA in specimens. However, there are two main constraints.
Cassandra Koh, Lionel Frangeul, Hervé Blanc, Carine Ngoagouni, Sébastien Boyer, Philippe Dussart, Nina Grau, Romain Girod, Jean-Bernard Duchemin, Maria-Carla Saleh   +9 more
doaj   +1 more source

Visualization of positive and negative sense viral RNA for probing the mechanism of direct-acting antivirals against hepatitis C virus [PDF]

, 2019
RNA viruses are highly successful pathogens and are the causative agents for many important diseases. To fully understand the replication of these viruses it is necessary to address the roles of both positive-strand RNA ((+)RNA) and negative-strand RNA ((
Bassit, Leda C, Huber, Andrew D, Ji, Juan, Lan, Shuiyun, Liu, Dandan, Michailidis, Eleftherios, Ndongwe, Tanyaradzwa P, Puray-Chavez, Maritza N, Ralston, Robert, Rice, Charles M, Saeed, Mohsan, Sarafianos, Stefan G, Schinazi, Raymond F, Tedbury, Philip R   +13 more
core   +2 more sources

Viruses: Overturning RNA Turnover [PDF]

RNA Biology, 2006
It is becoming clear that viruses interface with the mRNA decay machinery in a variety of ways during an infection. First, RNA viruses in particular must evade the mRNA decay machinery long enough to replicate and establish infection. Second, many viruses usurp or augment cellular mRNA decay pathways to regulate or selectively express their own genes ...
Kevin J, Sokoloski, Carol J, Wilusz, Jeffrey, Wilusz   +2 more
openaire   +2 more sources

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

Protein & Cell, 2020
Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2.
Rui Xiong, Lei-ke Zhang, Shiliang Li, Yuanyuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, W. Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Yu Chen, Yingle Liu, Gang Zou, Dimitri Lavillete, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, K. Lan, Honglin Li, Ke Xu   +24 more
semanticscholar   +1 more source

Evolutionary Selection of the Nuclear Localization Signal in the Viral Nucleoprotein Leads to Host Adaptation of the Genus Orthobornavirus

Viruses, 2020
Adaptation of the viral life cycle to host cells is necessary for efficient viral infection and replication. This evolutionary process has contributed to the mechanism for determining the host range of viruses.
Ryo Komorizono, Yukiko Sassa, Masayuki Horie, Akiko Makino, Keizo Tomonaga   +4 more
doaj   +1 more source