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Vaccines against RNA Viruses [PDF]
Vaccines, 2020 RNA viruses cause animal, human, and zoonotic diseases that affect millions of individuals, as is being exemplified by the devastating ongoing epidemic of the recently identified SARS-Cov-2 [...]
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Uirusu, 2008 Small RNAs play a critical role in the regulation of gene expression in diverse cellular processes. This mechanism, termed RNA silencing or RNAi, also functions as a defense mechanism against molecular parasites such as virus and transposon. Whereas RNA silencing is triggered by viral infection, viruses suppress RNA silencing to establish infection ...
MINE, Akira, OKUNO, Tetsuro
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mSphere, 2017 The optimized exploitation of cell resources is one cornerstone of a successful infection. Differential mapping of host-pathogen protein-protein interactions (PPIs) on the basis of comparative interactomics of multiple strains is an effective strategy to
Elise Biquand +14 more
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Microbiology Spectrum, 2016 Acute upper and lower respiratory infections are a major public health problem and a leading cause of morbidity and mortality worldwide. At greatest risk are young children, the elderly, the chronically ill, and those with suppressed or compromised immune systems.
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PicPreview and PicSummary: Two Timesaving Plugins for the Fluorescence Microscopist
Cells, 2021 This article targets cell biologists who use fluorescence microscopy but lack automatic tools to summarize and manage their image datasets. When using microscopy to document a phenotype, multiple and random pictures are required to reflect the biological
Gabrielle Vieyres
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Manipulation of autophagy by (+) RNA viruses [PDF]
Seminars in Cell & Developmental Biology, 2020 Autophagy is an evolutionarily conserved process central to host metabolism. Among its major functions are conservation of energy during starvation, recycling organelles, and turnover of long-lived proteins. Besides, autophagy plays a critical role in removing intracellular pathogens and very likely represents a primordial intrinsic cellular defence ...
Wong, Ho Him, Sanyal, Sumana
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Development of an RNA Virus-Based Episomal Vector Capable of Switching Transgene Expression
Frontiers in Microbiology, 2019 Viral vectors are efficient gene delivery systems, although most of these vectors still present limitations to their practical use, such as achieving only transient transgene expression and a risk of insertional mutations.
Yusuke Yamamoto +5 more
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A novel SARS-CoV-2 related coronavirus in bats from Cambodia
Nature Communications, 2021 In this study, Delaune et al., isolate and characterise a SARS-CoV-2-related coronavirus from two bats sampled in Cambodia. Their findings suggest that the geographic distribution of SARS-CoV-2-related viruses is wider than previously reported.
Deborah Delaune +17 more
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Early phylodynamics analysis of the COVID-19 epidemic in France
Peer Community Journal, 2021 France was one of the first countries to be reached by the COVID-19 pandemic. Here, we analyse 196 SARS-Cov-2 genomes collected between Jan 24 and Mar 24 2020, and perform a phylodynamics analysis.
Danesh, Gonché +17 more
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Discovering the Phylodynamics of RNA Viruses
PLoS Computational Biology, 2009 1 Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, Pennsylvania, United States of America, 2 Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America, 3 Department of Ecology and Evolutionary Biology and Woodrow Wilson ...
Edward C. Holmes, Bryan T. Grenfell
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