Results 11 to 20 of about 389,265 (219)

Intranasal immunization with avian paramyxovirus type 3 expressing SARS-CoV-2 spike protein protects hamsters against SARS-CoV-2

npj Vaccines, 2022
Current vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are administered parenterally and appear to be more protective in the lower versus the upper respiratory tract.
Hong-Su Park, Yumiko Matsuoka, Cindy Luongo, Lijuan Yang, Celia Santos, Xueqiao Liu, Laura R. H. Ahlers, Ian N. Moore, Sharmin Afroz, Reed F. Johnson, Bernard A. P. Lafont, David W. Dorward, Elizabeth R. Fischer, Craig Martens, Siba K. Samal, Shirin Munir, Ursula J. Buchholz, Cyril Le Nouën   +17 more
doaj   +1 more source

Ribosomal RNA (rRNA) sequences from 33 globally distributed mosquito species for improved metagenomics and species identification

eLife, 2023
Total RNA sequencing (RNA-seq) is an important tool in the study of mosquitoes and the RNA viruses they vector as it allows assessment of both host and viral RNA in specimens. However, there are two main constraints.
Cassandra Koh, Lionel Frangeul, Hervé Blanc, Carine Ngoagouni, Sébastien Boyer, Philippe Dussart, Nina Grau, Romain Girod, Jean-Bernard Duchemin, Maria-Carla Saleh   +9 more
doaj   +1 more source

In vivo biodistribution analysis of transmission competent and defective RNA virus-based episomal vector

Scientific Reports, 2020
RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro.
Yumiko Komatsu, Chiaki Tanaka, Ryo Komorizono, Keizo Tomonaga   +3 more
doaj   +1 more source

Evolutionary Selection of the Nuclear Localization Signal in the Viral Nucleoprotein Leads to Host Adaptation of the Genus Orthobornavirus

Viruses, 2020
Adaptation of the viral life cycle to host cells is necessary for efficient viral infection and replication. This evolutionary process has contributed to the mechanism for determining the host range of viruses.
Ryo Komorizono, Yukiko Sassa, Masayuki Horie, Akiko Makino, Keizo Tomonaga   +4 more
doaj   +1 more source

SARS‐CoV‐2 Omicron emergence urges for reinforced One‐Health surveillance

EMBO Molecular Medicine, 2022
Graphical Abstract SARS‐CoV‐2 Omicron harbors substitutions in the receptor binding domain of the spike which strongly suggest its capacity to infect rodents.
Xavier Montagutelli, Sylvie van der Werf, Felix A Rey, Etienne Simon‐Loriere   +3 more
doaj   +1 more source

Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans

mSphere, 2017
The optimized exploitation of cell resources is one cornerstone of a successful infection. Differential mapping of host-pathogen protein-protein interactions (PPIs) on the basis of comparative interactomics of multiple strains is an effective strategy to
Elise Biquand, Juline Poirson, Marwah Karim, Marion Declercq, Nicolas Malausse, Patricia Cassonnet, Cyril Barbezange, Marie-Laure Straub, Louis Jones, Sandie Munier, Nadia Naffakh, Sylvie van der Werf, Yves Jacob, Murielle Masson, Caroline Demeret   +14 more
doaj   +1 more source

PicPreview and PicSummary: Two Timesaving Plugins for the Fluorescence Microscopist

Cells, 2021
This article targets cell biologists who use fluorescence microscopy but lack automatic tools to summarize and manage their image datasets. When using microscopy to document a phenotype, multiple and random pictures are required to reflect the biological
Gabrielle Vieyres
doaj   +1 more source

Development of an RNA Virus-Based Episomal Vector Capable of Switching Transgene Expression

Frontiers in Microbiology, 2019
Viral vectors are efficient gene delivery systems, although most of these vectors still present limitations to their practical use, such as achieving only transient transgene expression and a risk of insertional mutations.
Yusuke Yamamoto, Yusuke Yamamoto, Keizo Tomonaga, Keizo Tomonaga, Keizo Tomonaga, Tomoyuki Honda   +5 more
doaj   +1 more source

A novel SARS-CoV-2 related coronavirus in bats from Cambodia

Nature Communications, 2021
In this study, Delaune et al., isolate and characterise a SARS-CoV-2-related coronavirus from two bats sampled in Cambodia. Their findings suggest that the geographic distribution of SARS-CoV-2-related viruses is wider than previously reported.
Deborah Delaune, Vibol Hul, Erik A. Karlsson, Alexandre Hassanin, Tey Putita Ou, Artem Baidaliuk, Fabiana Gámbaro, Matthieu Prot, Vuong Tan Tu, Sokha Chea, Lucy Keatts, Jonna Mazet, Christine K. Johnson, Philippe Buchy, Philippe Dussart, Tracey Goldstein, Etienne Simon-Lorière, Veasna Duong   +17 more
doaj   +1 more source

Early phylodynamics analysis of the COVID-19 epidemic in France

Peer Community Journal, 2021
France was one of the first countries to be reached by the COVID-19 pandemic. Here, we analyse 196 SARS-Cov-2 genomes collected between Jan 24 and Mar 24 2020, and perform a phylodynamics analysis.
Danesh, Gonché, Elie, Baptiste, Michalakis, Yannis, Sofonea, Mircea T, Bal, Antonin, Behillil, Sylvie, Destras, Grégory, Boutolleau, David, Burrel, Sonia, Marcelin, Anne-Geneviève, Plantier, Jean-Christophe, Thibault, Vincent, Simon-Loriere, Etienne, van der Werf, Sylvie, Lina, Bruno, Josset, Laurence, Enouf, Vincent, Alizon, Samuel   +17 more
doaj   +1 more source