Results 1 to 10 of about 2,427,240 (308)

Induction of translation-suppressive G3BP1+ stress granules and interferon-signaling cGAS condensates by transfected plasmid DNA

hLife
Plasmid DNA transfection is one of the fundamental tools of biomedical research. Here, we found that plasmid DNA transfection mediated by liposomes activates multiple innate immune responses in several widely used cell lines.
Vladimir Majerciak, Zhi-Ming Zheng
doaj   +1 more source

RNA of mouse hepatitis virus [PDF]

Journal of Virology, 1978
The RNA of mouse hepatitis virus, a coronavirus, was isolated from the virus released early in the infection and analyzed by sucrose gradient sedimentation and electrophoresis. It was found to consist of a piece of single-stranded RNA of about 60S. Its molecular weight was estimated to be 5.4 X 10(6) by electrophoresis in methylmercury-agarose gels. At
M M, Lai, S A, Stohlman
openaire   +2 more sources

The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells

eLife
Increased expression of lnc-FANCI-2, a newly discovered long noncoding RNA, is associated with cervical lesion progression from cervical intraepithelial neoplasia stage 1 (CIN1, low grade), CIN2–3 (high grade), to cervical cancer. Viral oncoprotein E7 of
Haibin Liu, Lulu Yu, Vladimir Majerciak, Thomas J Meyer, Ming Yi, Peter F Johnson, Maggie Cam, Douglas R Lowy, Zhi-Ming Zheng   +8 more
doaj   +1 more source

RNA Virus Populations as Quasispecies [PDF]

, 1992
RNA virus mutation frequencies generally approach maximum tolerable levels, and create complex indeterminate quasispecies populations in infected hosts. This usually favors extreme rates of evolution, although periods of relative stasis or equilibrium, punctuated by rapid change may also occur (as for other life forms).
J J, Holland, J C, De La Torre, D A, Steinhauer   +2 more
openaire   +2 more sources

Multiple Regions of Kaposi’s Sarcoma-Associated Herpesvirus ORF59 RNA are Required for Its Expression Mediated by Viral ORF57 and Cellular RBM15

Viruses, 2015
KSHV ORF57 (MTA) promotes RNA stability of ORF59, a viral DNA polymerase processivity factor. Here, we show that the integrity of both ORF59 RNA ends is necessary for ORF57-mediated ORF59 expression and deletion of both 5’ and 3’ regions, or one end ...
Maria Julia Massimelli, Vladimir Majerciak, Jeong-Gu Kang, David J. Liewehr, Seth M. Steinberg, Zhi-Ming Zheng   +5 more
doaj   +1 more source

Bovine Leukemia Virus: An Exogenous RNA Oncogenic Virus? [PDF]

Proceedings of the National Academy of Sciences, 1976
Short-term cultures of bovine leukemic lymphocytes release virus particles with biochemical properties of RNA oncogenic viruses. These particles, tentatively called bovine leukemia virus (BLV), have a high molecular weight RNA-reverse transcriptase complex and a density of 1.155 g/ml in sucrose solutions.
Kettmann, Richard, Portetelle, Daniel, Mammerickx, Marc, Cleuter, Yvette, Dekegel, Daniel, Galoux, Michel, Ghysdael, Jacques, Burny, Arsène, Chantrenne, Hubert   +8 more
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Oncogenes and RNA splicing of human tumor viruses

Emerging Microbes and Infections, 2014
Approximately 10.8% of human cancers are associated with infection by an oncogenic virus. These viruses include human papillomavirus (HPV), Epstein–Barr virus (EBV), Merkel cell polyomavirus (MCV), human T-cell leukemia virus 1 (HTLV-1), Kaposi's sarcoma-
Masahiko Ajiro, Zhi-Ming Zheng
doaj   +1 more source

The Segment Matters: Probable Reassortment of Tilapia Lake Virus (TiLV) Complicates Phylogenetic Analysis and Inference of Geographical Origin of New Isolate from Bangladesh

Viruses, 2020
Tilapia lake virus (TiLV), a negative sense RNA virus with a 10 segment genome, is an emerging threat to tilapia aquaculture worldwide, with outbreaks causing over 90% mortality reported on several continents since 2014.
Dominique L. Chaput, David Bass, Md. Mehedi Alam, Neaz Al Hasan, Grant D. Stentiford, Ronny van Aerle, Karen Moore, John P. Bignell, Mohammad Mahfujul Haque, Charles R. Tyler   +9 more
doaj   +1 more source

RNA splicing in Borna disease virus, a nonsegmented, negative-strand RNA virus [PDF]

Journal of Virology, 1994
Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus related to rhabdoviruses and paramyxoviruses. Unlike animal viruses of these two families, BDV transcribes RNAs in the nuclei of infected cells and produces high levels of transcripts containing multiple open reading frames.
P A, Schneider, A, Schneemann, W I, Lipkin   +2 more
openaire   +2 more sources

A Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation

Viruses, 2019
Mumps virus (MuV) is a neurotropic non-segmented, negative-stranded, enveloped RNA virus in the Paramyxovirus family. The 15.4 kb genome encodes seven genes, including the V/P, which encodes, among other proteins, the V protein.
Tahir Malik, Laurie Ngo, Trent Bosma, Steven Rubin   +3 more
doaj   +1 more source