Results 11 to 20 of about 815,962 (317)

Structural Constraints on RNA Virus Evolution [PDF]

Journal of Virology, 1999
ABSTRACT The recently discovered hepatitis G virus (HGV) or GB virus C (GBV-C) is widely distributed in human populations, and homologues such as HGV/GBV-C CPZ and GBV-A are found in a variety of different primate species.
Simmonds, P, Smith, D B
openaire   +5 more sources

Possible roles of endogenous RNA virus elements in RNA virus infection

Uirusu, 2016
Endogenous bornavirus-like elements (EBLs) are ancient bornavirus-derived sequence in the genomes of eukaryotes. Expression profile of EBLs suggests that, although most of the EBLs in mammalian genomes have lost their coding potential, many of them are transcribed in a cell-type specific or ubiquitous manner. This observation leads us to speculate that
Tomoyuki, Honda, Keizo, Tomonaga
openaire   +6 more sources

Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein

Virology Journal, 2017
Background Borna disease virus (BoDV), which has a negative-sense, single-stranded RNA genome, causes persistent infection in the cell nucleus. The nuclear export signal (NES) of the viral nucleoprotein (N) consisting of leucine at positions 128 and 131 ...
Mako Yanai, Madoka Sakai, Akiko Makino, Keizo Tomonaga   +3 more
doaj   +1 more source

Evolutionary Selection of the Nuclear Localization Signal in the Viral Nucleoprotein Leads to Host Adaptation of the Genus Orthobornavirus

Viruses, 2020
Adaptation of the viral life cycle to host cells is necessary for efficient viral infection and replication. This evolutionary process has contributed to the mechanism for determining the host range of viruses.
Ryo Komorizono, Yukiko Sassa, Masayuki Horie, Akiko Makino, Keizo Tomonaga   +4 more
doaj   +1 more source

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence [PDF]

, 2004
Discrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and ...
Evans, David J, Simmonds, Peter, Tuplin, Andrew, Tuplin, A, Evans, DJ, Simmonds, P   +5 more
core   +1 more source

One Hour Photo, Seymour Parrish, gnosticism, Demiurge, early Christianity, religious symbolism, cinema, sin, punishment, sword [PDF]

Future Human Image, 2022
This article focuses on the architecture of intersection that exists between emerging infectious diseases, conflict and global governance. Using COVID-19 as both the backdrop for a failed global response as well as a predictive exercise for future ...
Sanjay Pooran
doaj   +1 more source

A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]

, 2008
The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad, Elliot, R., Evans, David John, Evans, D., Armstrong, V, Tuplin, Andrew, Evans, D.J., Struthers, Madeleine, Struthers, M., Elliott, Richard M., Diviney, S., Tuplin, A., Armstrong, V., Struthers, M, Simmonds, Peter, Elliott, Richard Michael, Armstrong, Victoria, Tuplin, A, Evans, David J., Simmonds, P., Diviney, S, Elliott, R.M., Simmonds, P   +22 more
core   +1 more source

Challenges in RNA virus bioinformatics [PDF]

Bioinformatics, 2014
Abstract Motivation: Computer-assisted studies of structure, function and evolution of viruses remains a neglected area of research. The attention of bioinformaticians to this interesting and challenging field is far from commensurate with its medical and biotechnological importance.
Manja Marz, Niko Beerenwinkel, Christian Drosten, Markus Fricke, Dmitrij Frishman, Ivo L. Hofacker, Dieter Hoffmann, Martin Middendorf, Thomas Rattei, Peter F. Stadler, Armin Töpfer   +10 more
openaire   +6 more sources

Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]

, 2013
Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Richard M. Elliott, Böttcher, Bettina, Li, P., Dong, H., Li, Ping, Dong, Changjiang, Dong, Haohao, Elliott, R., Boettcher, Bettina, Elliott, Richard M., Bottcher, B., Haohao Dong, Bettina Böttcher, Ping Li, Elliott, Richard M, Dong, C., Changjiang Dong   +16 more
core   +1 more source

Revisiting and corrections to the annotated SRSF3 (SRp20) gene structure and RefSeq sequences from the human and mouse genomes

Cell Insight, 2023
SRSF3 (SRp20) is the smallest member of the serine/arginine (SR)-rich protein family. We found the annotated human SRSF3 and mouse Srsf3 RefSeq sequences are much larger than the detected SRSF3/Srsf3 RNA size by Northern blot.
Lulu Yu, Vladimir Majerciak, Rong Jia, Zhi-Ming Zheng   +3 more
doaj   +1 more source