Results 11 to 20 of about 844,830 (315)
CRISPR/Cas13-Based Anti-RNA Viral Approaches. [PDF]
Genes (Basel)RNA viruses pose significant threats to global health, causing diseases such as COVID-19, HIV/AIDS, influenza, and dengue. These viruses are characterized by high mutation rates, rapid evolution, and the ability to evade traditional antiviral therapies ...
Tan X +6 more
europepmc +2 more sources
Viral RNA as a Branched Polymer
, 2023 24 pages, 9 ...
Vaupotič, Domen +4 more
openaire +4 more sources
A discontinuous RNA platform mediates RNA virus replication: building an integrated model for RNA-based regulation of viral processes. [PDF]
PLoS Pathogens, 2009 Plus-strand RNA viruses contain RNA elements within their genomes that mediate a variety of fundamental viral processes. The traditional view of these elements is that of local RNA structures.
Baodong Wu +5 more
doaj +1 more source
Uirusu, 2009 Many lines of recent evidence indicate that non-coding RNAs including micro RNAs (miRNAs) and small interfering RNAs (siRNAs) play an important role in the control of gene expression in diverse cellular processes and in defense responses against molecular parasites such as viruses and transposons.
IWAKAWA, Hiro-oki, OKUNO, Testuro
openaire +3 more sources
Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export [PDF]
, 2014 This work is supported by grants from the Wellcome Trust (grants 087751/A/08/Z) and MRC (G1001726/1).We have examined the requirements for virus transcription and replication and thus the roles of input and progeny genomes in the generation of interferon
Randall, Richard E +3 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2022 Viruses package host RNAs in their virions which are associated with a range of functions in the viral life cycle. Previous transcriptomic profiling of host RNA packaging mostly focused on retroviruses.
Noah Peña +21 more
doaj +1 more source
A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]
, 2008 The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad +22 more
core +1 more source
Nucleocapsid Structure of Negative Strand RNA Virus
Viruses, 2020 Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis ...
Ming Luo +2 more
doaj +1 more source
mBio, 2021 Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire of drugs, often ...
Ana Cristina Gonzalez-Perez +14 more
doaj +1 more source
The influence of viral RNA secondary structure on interactions with innate host cell defences [PDF]
, 2013 RNA viruses infecting vertebrates differ fundamentally in their ability to establish persistent infections with markedly different patterns of transmission, disease mechanisms and evolutionary relationships with their hosts.
Blundell, Richard +13 more
core +1 more source