Results 11 to 20 of about 2,786,263 (356)
RNA modifications go viral. [PDF]
PLoS Pathogens, 2017 Nandan S Gokhale, Stacy M Horner
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Amuvatinib Blocks SARS-CoV-2 Infection at the Entry Step of the Viral Life Cycle
Microbiology Spectrum, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). SARS-CoV-2 propagation is mediated by the protein interaction between viral proteins and host cells.
Trang T. X. Huynh +7 more
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The Lancet Gastroenterology and Hepatology, 2023 Summary Background Point-of-care (POC) hepatitis C virus (HCV) RNA nucleic acid test viral load assays are being used increasingly as an alternative to centralised, laboratory-based standard-of-care (SOC) viral load assays to reduce loss to follow-up. We
A. Trickey +4 more
semanticscholar +1 more source
A natural product YSK-A blocks SARS-CoV-2 propagation by targeting multiple host genes
Scientific Reports, 2023 Natural products and herbal medicine have been widely used in drug discovery for treating infectious diseases. Recent outbreak of COVID-19 requires various therapeutic strategies.
Thuy X. Pham +4 more
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Nature Communications, 2021 Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally ...
Veronica V. Rezelj +23 more
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CRISPR/Cas13-Based Anti-RNA Viral Approaches. [PDF]
Genes (Basel)RNA viruses pose significant threats to global health, causing diseases such as COVID-19, HIV/AIDS, influenza, and dengue. These viruses are characterized by high mutation rates, rapid evolution, and the ability to evade traditional antiviral therapies ...
Tan X +6 more
europepmc +2 more sources
RNA Interference for Viral Infections [PDF]
Current Drug Targets, 2012 The treatment of viral infections has relied on pre-emptive vaccination or use of a limited range of anti-viral drugs. However, the majority of viruses have no available drugs and treatment is merely supportive. RNA interference (RNAi) offers the ability to directly and rapidly treat virus infections via the targeting of viral genes.
Blake, Stephen J. +2 more
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Reovirus Low-Density Particles Package Cellular RNA
Viruses, 2021 Packaging of segmented, double-stranded RNA viral genomes requires coordination of viral proteins and RNA segments. For mammalian orthoreovirus (reovirus), evidence suggests either all ten or zero viral RNA segments are simultaneously packaged in a ...
Timothy W. Thoner +3 more
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A viral deubiquitylating enzyme targets viral RNA‐dependent RNA polymerase and affects viral infectivity [PDF]
The EMBO Journal, 2011 Selective protein degradation via the ubiquitin-proteasome system (UPS) plays an essential role in many major cellular processes, including host-pathogen interactions. We previously reported that the tightly regulated viral RNA-dependent RNA polymerase (RdRp) of the positive-strand RNA virus Turnip yellow mosaic virus (TYMV) is degraded by the UPS in ...
Chenon, Mélanie +3 more
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Viral RNA as a Branched Polymer
, 2023 24 pages, 9 ...
Vaupotič, Domen +4 more
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