Results 41 to 50 of about 1,114,234 (207)

All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes

Frontiers in Immunology, 2020
Interferon (IFN) signaling induces the expression of a wide array of genes, collectively referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication.
Emily Yang, Emily Yang, Melody M. H. Li, Melody M. H. Li   +3 more
doaj   +1 more source

RNA Structures and Their Role in Selective Genome Packaging

Viruses, 2021
To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs.
Liqing Ye, Uddhav B. Ambi, Marco Olguin-Nava, Anne-Sophie Gribling-Burrer, Shazeb Ahmad, Patrick Bohn, Melanie M. Weber, Redmond P. Smyth   +7 more
doaj   +1 more source

Effects of RNA branching on the electrostatic stabilization of viruses [PDF]

, 2016
Many single-stranded (ss) RNA viruses self assemble from capsid protein subunits and the nucleic acid to form an infectious virion. It is believed that the electrostatic interactions between the negatively charged RNA and the positively charged viral ...
Erdemci-Tandogan, Gonca, Podgornik, Rudolf, van der Schoot, Paul, Wagner, Jef, Zandi, Roya   +4 more
core   +3 more sources

Single genome sequencing of near full-length HIV-1 RNA using a limiting dilution approach [PDF]

, 2019
Sequencing very long stretches of the HIV-1 genome can advance studies on virus evolution and in vivo recombination but remains technically challenging.
Demecheleer, Els, Hardy, Jarryt, Hebberecht, Laura, Mortier, Virginie, Schauvliege, Marlies, Staelens, Delfien, Vancoillie, Leen, Verhofstede, Chris   +7 more
core   +1 more source

Discontinuous template switching generates coronavirus subgenomic RNAs from the 3ʹ viral genome end by 5ʹ to 3ʹ transcription

Journal of Virology
In coronavirus (CoV)-infected cells, several structural and accessory proteins are synthesized from subgenome RNAs (sgRNA) containing a common genomic 5ʹ-leader followed by a given open reading frame (ORF).
Ayslan Castro Brant, Zhe Hu, Angelika Zelma Chen, Vladimir Majerciak, Jonathan Yewdell, Zhi-Ming Zheng   +5 more
doaj   +1 more source

Staufen1 Protein Participates Positively in the Viral RNA Replication of Enterovirus 71

Viruses, 2019
The double-stranded RNA-binding protein Staufen1 (Stau1) has multiple functions during RNA virus infection. In this study, we investigated the role of Stau1 in viral translation by using a combination of enterovirus 71 (EV-A71) infection, RNA reporter ...
Young-Mao Chen, Bo-Ting Ou, Chao-Ying Chen, Han-Hsiang Chan, Chih-Jung Chen, Robert YL Wang   +5 more
doaj   +1 more source

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]

, 2017
Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K, Basler, Christopher F, Batra, Jyoti, Leung, Daisy W, Luthra, Priya, Wu, Chao, Xu, Wei   +6 more
core   +2 more sources

Viral RNA export

Chemistry & Biology, 1997
Viruses can express intron-containing and intronless mRNAs, which are exported by alternative pathways. The study of the nuclear export of these unconventional mRNAs can provide key insights into the normal process of nuclear export and the alternative pathways provide an attractive target for the development of specific antiviral therapies.
openaire   +2 more sources

Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication

mBio, 2021
The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an ongoing global public crisis. Although viral RNA modification has been reported based on the transcriptome architecture, the types and ...
Xueyan Zhang, Haojie Hao, Li Ma, Yecheng Zhang, Xiao Hu, Zhen Chen, Di Liu, Jianhui Yuan, Zhangli Hu, Wuxiang Guan   +9 more
doaj   +1 more source

Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins [PDF]

, 2018
The HIV-1 nucleocapsid (NC) protein represents an excellent molecular target for the development of antiretrovirals by virtue of its well-characterized chaperone activities, which play pivotal roles in essential steps of the viral life cycle. Our ongoing
Caliendo, Giuseppe, Carraro, Caterina, Corvino, Angela, Di Vaio, Paola, Fabris, Dan, Fiorino, Ferdinando, Frecentese, Francesco, Gamba, Elia, Gatto, Barbara, Kenderdine, Thomas, Magli, Elisa, Perissutti, Elisa, Saccone, Irene, Santagada, Vincenzo, Severino, Beatrice, Sosic, Alice, Spada, Valentina   +16 more
core   +2 more sources