Influence of viral genes on the cell-to-cell spread of RNA silencing [PDF]
The turnip crinkle virus-based vector TCV–GFPDCP had been devised previously to study cell-to-cell and long-distance spread of virus-induced RNA silencing.
Hong, Yiguo +3 more
core +1 more source
Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence [PDF]
, 2004 Discrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and ...
Evans, David J +5 more
core +1 more source
Critical Care, 2020 Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus.
Jesús F. Bermejo-Martin +65 more
doaj +1 more source
Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding
Cell Discovery, 2022 Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level IgG antibodies and higher regulatory T (Treg ...
Xiaohua Tang +31 more
doaj +1 more source
Kissing interaction between 3' noncoding and coding sequences is essential for porcine arterivirus RNA replication [PDF]
, 2002 We used an infectious cDNA clone of Porcine reproductive and respiratory syndrome virus (PRRSV) to investigate the presence of essential replication elements in the region of the genome encoding the structural proteins.
R. C. L. Olsthoorn +10 more
core +2 more sources
The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome.
PLoS Pathogens, 2011 Viruses have to encapsidate their own genomes during the assembly process. For most RNA viruses, there are sequences within the viral RNA and virion proteins needed for high efficiency of genome encapsidation.
Shuyuarn F Yu +4 more
doaj +1 more source
Protein expression redirects vesicular stomatitis virus RNA synthesis to cytoplasmic inclusions. [PDF]
PLoS Pathogens, 2010 Positive-strand and double-strand RNA viruses typically compartmentalize their replication machinery in infected cells. This is thought to shield viral RNA from detection by innate immune sensors and favor RNA synthesis. The picture for the non-segmented
Bianca S Heinrich +3 more
doaj +1 more source
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
mBioCoronaviruses (CoVs) hijack host RNA-binding proteins (RBPs) to facilitate their replication, but the viral proteins and host RBDs that participate in the synthesis of viral RNA and protein are unclear.
Yuchang Liu +14 more
doaj +1 more source
Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles
mBio, 2021 The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication
Christopher H. Lee +8 more
doaj +1 more source