Results 61 to 70 of about 2,786,263 (356)

Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection. [PDF]

, 2012
During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the real ...
Lisa Marcinowski, Martina Rieder, Caroline C. Friedel (7812728), Marcinowski, Lisa, Lars Dölken, de Graaf, Miranda, Thomas Bonfert, Caroline C. Friedel (29226), Lars Dölken (138985), Györy, Ildiko, Caroline C Friedel, Philip Rosenstiel (68103), Jens B Bosse, Ruzsics, Zsolt, Ralf Zimmer, Bosse, Jens B., Lukas Windhager, Rosenstiel, Philip, Zsolt Ruzsics (75383), Jens B. Bosse (7812725), Zimmer, Ralf, Thomas Bonfert (138970), Rieder, Martina, Lisa Marcinowski (138962), Jens B. Bosse (138966), Friedel, Caroline C., Ildiko Györy (138972), Michael Lidschreiber, Ildiko Györy, Bernd Rädle (138968), Zsolt Ruzsics, Ralf Zimmer (21157), Windhager, Lukas, Miranda de Graaf, Philip Rosenstiel, Michael Lidschreiber (138963), Dölken, Lars, Olivia Prazeres da Costa, Prazeres da Costa, Olivia, Olivia Prazeres da Costa (138979), Bernd Rädle, Lukas Windhager (138964), Lidschreiber, Michael, Miranda de Graaf (138976), Bonfert, Thomas, Rädle, Bernd, Martina Rieder (138965)   +46 more
core   +1 more source

Exosome-mediated PROTAC delivery for treatment of RNA viral infections and zoonoses.

Drug Discovery Today
The increase in diseases caused by RNA viruses, such as influenza, severe acute respiratory syndrome-coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS), and Ebola, presents a growing global health challenge as well as the threat of zoonosis.
Nobendu Mukerjee, Swastika Maitra, Arabinda Ghosh, Athanasios Alexiou, N. Thorat   +4 more
semanticscholar   +1 more source

Activation and Role of NACHT, LRR, and PYD Domains-Containing Protein 3 Inflammasome in RNA Viral Infection

Frontiers in Immunology, 2017
NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation and effects during ribonucleic acid (RNA) viral infection are the focus of a wide range of research currently.
Junyang Yu, Yuzhang Wu, Jingxue Wang
semanticscholar   +1 more source

Viral RNAs Are Unusually Compact

PLoS ONE, 2014
A majority of viruses are composed of long single-stranded genomic RNA molecules encapsulated by protein shells with diameters of just a few tens of nanometers. We examine the extent to which these viral RNAs have evolved to be physically compact molecules to facilitate encapsulation. Measurements of equal-length viral, non-viral, coding and non-coding
Gopal, Ajaykumar, Egecioglu, Defne E, Yoffe, Aron M, Ben-Shaul, Avinoam, Rao, Ayala LN, Knobler, Charles M, Gelbart, William M   +6 more
openaire   +6 more sources

Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis. [PDF]

, 2012
BACKGROUND: Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus of the Reoviridae family, which encodes its genes in ten linear dsRNA segments.
Roy Polly, Boyce, Mark, Roy, Polly, Celma, Cristina CP, Cristina C P Celma, Boyce Mark, Mark Boyce, Polly Roy, Celma Cristina C P   +8 more
core   +1 more source

Discontinuous template switching generates coronavirus subgenomic RNAs from the 3ʹ viral genome end by 5ʹ to 3ʹ transcription

Journal of Virology
In coronavirus (CoV)-infected cells, several structural and accessory proteins are synthesized from subgenome RNAs (sgRNA) containing a common genomic 5ʹ-leader followed by a given open reading frame (ORF).
Ayslan Castro Brant, Zhe Hu, Angelika Zelma Chen, Vladimir Majerciak, Jonathan Yewdell, Zhi-Ming Zheng   +5 more
doaj   +1 more source

Factors associated with prolonged viral RNA shedding in patients with COVID-19

Clinical Infectious Diseases, 2020
Background An outbreak of coronavirus disease 2019 (COVID-19) is becoming a public health emergency. Data are limited on the duration and host factors related to viral shedding.
Kaijin Xu, Yanfei Chen, Jing Yuan, Ping Yi, Cheng Ding, Wen-rui Wu, Yongtao Li, Qin Ni, Rongrong Zou, Xiaohe Li, Min Xu, Ying Zhang, Hong Zhao, Xuan Zhang, Liang Yu, Jun-wei Su, Guan-jing Lang, Jun Liu, Xiaoxin Wu, Yong-zheng Guo, Jingjing Tao, D. Shi, Ling Yu, Qing Cao, B. Ruan, Lei Liu, Zhaoqin Wang, Yan Xu, Yingxia Liu, J. Sheng, Lanjuan Li   +30 more
semanticscholar   +1 more source

Viral RNA export

Chemistry & Biology, 1997
Viruses can express intron-containing and intronless mRNAs, which are exported by alternative pathways. The study of the nuclear export of these unconventional mRNAs can provide key insights into the normal process of nuclear export and the alternative pathways provide an attractive target for the development of specific antiviral therapies.
openaire   +2 more sources

Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication

mBio, 2021
The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an ongoing global public crisis. Although viral RNA modification has been reported based on the transcriptome architecture, the types and ...
Xueyan Zhang, Haojie Hao, Li Ma, Yecheng Zhang, Xiao Hu, Zhen Chen, Di Liu, Jianhui Yuan, Zhangli Hu, Wuxiang Guan   +9 more
doaj   +1 more source

Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity

Emerging Microbes and Infections, 2020
The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab.
Weilie Chen, Y. Lan, Xiao-zhen Yuan, Xilong Deng, Yueping Li, Xiaoli Cai, Liya Li, Ruiying He, Yizhou Tan, Xizi Deng, Ming Gao, Guo-fang Tang, Ling-Zhai Zhao, Jinlin Wang, Qinghong Fan, C. Wen, Yuwei Tong, Yang-bo Tang, F. Hu, Feng Li, Xiaoping Tang   +20 more
semanticscholar   +1 more source