Results 81 to 90 of about 2,786,263 (356)
Protein expression redirects vesicular stomatitis virus RNA synthesis to cytoplasmic inclusions. [PDF]
PLoS Pathogens, 2010 Positive-strand and double-strand RNA viruses typically compartmentalize their replication machinery in infected cells. This is thought to shield viral RNA from detection by innate immune sensors and favor RNA synthesis. The picture for the non-segmented
Bianca S Heinrich +3 more
doaj +1 more source
Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles
mBio, 2021 The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication
Christopher H. Lee +8 more
doaj +1 more source
Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases.
Current Opinion in Structural Biology, 2016 Negative strand RNA viruses (NSVs), which may have segmented (sNSV) or non-segmented genomes (nsNSV) are responsible for numerous serious human infections such as Influenza, Measles, Rabies, Ebola, Crimean Congo Haemorrhagic Fever and Lassa Fever.
J. Reguera, P. Gerlach, S. Cusack
semanticscholar +1 more source
N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I
Nature Microbiology, 2020 Internal N6-methyladenosine (m6A) modification is one of the most common and abundant modifications of RNA. However, the biological roles of viral RNA m6A remain elusive. Here, using human metapneumovirus (HMPV) as a model, we demonstrate that m6A serves
Mijia Lu +14 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Expert Review of Vaccines, 2014 The advent of reverse genetic approaches to manipulate the genomes of both positive (+) and negative (-) sense RNA viruses allowed researchers to harness these genomes for basic research. Manipulation of positive sense RNA virus genomes occurred first largely because infectious RNA could be transcribed directly from cDNA versions of the RNA genomes ...
Mark A, Mogler, Kurt I, Kamrud
openaire +2 more sources
Icosahedral Packing of RNA Viral Genomes [PDF]
Physical Review Letters, 2005 4 pages revtex, 4 eps ...
Rudnick, Joseph, Bruinsma, Robijn
openaire +3 more sources
The potato mop-top virus TGB2 protein and viral RNA associate with chloroplasts and viral infection induces inclusions in the plastids [PDF]
, 2012 The potato mop-top virus (PMTV) triple gene block 2 (TGB2) movement proteins fused to monomeric red fluorescent protein (mRFP-TGB2) was expressed under the control of the PMTV subgenomic promoter from a PMTV vector.
Roberts, Alison G. +19 more
core +1 more source
The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome.
PLoS Pathogens, 2011 Viruses have to encapsidate their own genomes during the assembly process. For most RNA viruses, there are sequences within the viral RNA and virion proteins needed for high efficiency of genome encapsidation.
Shuyuarn F Yu +4 more
doaj +1 more source
Replicon RNA Viral Vectors as Vaccines
Vaccines, 2016 Single-stranded RNA viruses of both positive and negative polarity have been used as vectors for vaccine development. In this context, alphaviruses, flaviviruses, measles virus and rhabdoviruses have been engineered for expression of surface protein ...
K. Lundstrom
semanticscholar +1 more source