Results 81 to 90 of about 2,102,458 (307)

Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers. [PDF]

, 2014
We have previously documented the inhibitory activity of RNA aptamers to the RNA-dependent RNA polymerase of foot-and-mouth disease virus (3D(pol)). Here we report their modification and use with a subgenomic replicon incorporating GFP (pGFP-PAC replicon)
Forrest, S, Lear, Z, Ryan, M., Herod, M, Forrest, S., Ryan, M, Stonehouse, N.J., Rowlands, DJ, Herod, M.R., Stonehouse, NJ, Lear, Z., Rowlands, D.J., Ryan, M.; id_orcid   +12 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa. [PDF]

, 2011
Viral infection is a stimulus for apoptosis, and in order to sustain viral replication many viruses are known to carry genes encoding apoptosis inhibitors. F1L, encoded by the orthopoxvirus modified vaccinia virus Ankara (MVA) has a Bcl-2-like structure.
Potthoff, Stephanie, Häcker Georg, Sutter Gerd, Kastenmüller, Wolfgang, Drexler, I., Eitz Ferrer Pedro, Ludwig, H., Gasteiger Georg, Sutter, G., Gasteiger, Georg, Holger Ludwig, Stefan A Paschen, Stefan A. Paschen, Stephanie Potthoff, Potthoff, S., Susanne Kirschnek, Kirschnek, Susanne, Kastenmüller Wolfgang, Pedro Eitz Ferrer, Kirschnek, S., Häcker, Georg, Potthoff Stephanie, Villunger Andreas, Georg Gasteiger, Villunger, A., Ludwig, Holger, Georg Häcker, Drexler Ingo, Wolfgang Kastenmüller, Villunger, Andreas, Ingo Drexler, Gasteiger, G., Paschen, Stefan A., Sutter, Gerd, Häcker, G., Eitz Ferrer, Pedro, Kastenmüller, W., Kirschnek Susanne, Paschen Stefan A., Gerd Sutter, Ludwig Holger, Paschen, S.A., Andreas Villunger, Eitz Ferrer, P., Drexler, Ingo, Eitz Ferrer, P;Potthoff, S;Kirschnek, S;Gasteiger, G;Kastenmuller, W;Ludwig, H;Paschen, SA;Villunger, A;Sutter, G;Drexler, I;Häcker, G   +45 more
core   +2 more sources

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9

, 2023
Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To characterize host RNA-binding proteins (RBPs) involved in this process, we biochemically identified proteins bound to genomic and subgenomic SARS-CoV-2 RNAs. We find
Gabel, Alexander, Aydin, Jens, Lars Dölken, Hennig, Thomas, Pearce, Cadence, Sabina Ganskih, Makroczyova, Jana, Hasmik Keshishian, Smyth, Redmond, Simone Werner, Smyth, Redmond P., Zimmermann, Liv, Chlanda, Petr, Lambert Moyon, Zielinski, Sebastian, Lareau, Caleb A., Erhard, Florian, Jana Makroczyova, Kibe, Anuja, Krey, Karsten, Jens Aydin, Jochen Bodem, Cadence Pearce, Sebastian Stegmaier, Nora Schmidt, Steven A. Carr, Alexander Gabel, Karsten Krey, Ramya Potabattula, Carr, Steven, Schmidt, Nora;Ganskih, Sabina;Wei, Yuanjie;Gabel, Alexander;Zielinski, Sebastian;Keshishian, Hasmik;Lareau, Caleb A;Zimmermann, Liv;Makroczyova, Jana;Pearce, Cadence;Krey, Karsten;Hennig, Thomas;Stegmaier, Sebastian;Moyon, Lambert;Horlacher, Marc;Werner, Simone;Aydin, Jens;Olguin-Nava, Marco;Potabattula, Ramya;Kibe, Anuja;Dölken, Lars;Smyth, Redmond P;Caliskan, Neva;Marsico, Annalisa;Krempl, Christine;Bodem, Jochen;Pichlmair, Andreas;Carr, Steven A;Chlanda, Petr;Erhard, Florian;Munschauer, Mathias, Carr, Steven A., Sebastian Zielinski, Moyon, Lambert, Petr Chlanda, Pichlmair, Andreas, Schmidt, Nora, Liv Zimmermann, Neva Caliskan, Christine Krempl, Florian Erhard, Thomas Hennig, Ganskih, Sabina, Werner, Simone, Munschauer, Mathias, Olguin-Nava, Marco, Keshishian, Hasmik, Horlacher, Marc, Bodem, Jochen, Marsico, Annalisa, Dölken, Lars, Andreas Pichlmair, Lareau, Caleb, Wei, Yuanjie, Caliskan, Neva, Redmond P. Smyth, Potabattula, Ramya, Marc Horlacher, Yuanjie Wei, Marco Olguin-Nava, Anuja Kibe, Caleb A. Lareau, Mathias Munschauer, Annalisa Marsico, Stegmaier, Sebastian, Krempl, Christine, Schmidt, Nora;Ganskih, Sabina;Wei, Yuanjie;Gabel, Alexander;Zielinski, Sebastian;Keshishian, Hasmik;Lareau, Caleb A.;Zimmermann, Liv;Makroczyova, Jana;Pearce, Cadence;Krey, Karsten;Hennig, Thomas;Stegmaier, Sebastian;Moyon, Lambert;Horlacher, Marc;Werner, Simone;Aydin, Jens;Olguin-Nava, Marco;Potabattula, Ramya;Kibe, Anuja;Dölken, Lars;Smyth, Redmond P.;Caliskan, Neva;Marsico, Annalisa;Krempl, Christine;Bodem, Jochen;Pichlmair, Andreas;Carr, Steven A.;Chlanda, Petr;Erhard, Florian;Munschauer, Mathias   +66 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]

, 2013
Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Richard M. Elliott, Böttcher, Bettina, Li, P., Dong, H., Li, Ping, Dong, Changjiang, Dong, Haohao, Elliott, R., Boettcher, Bettina, Elliott, Richard M., Bottcher, B., Haohao Dong, Bettina Böttcher, Ping Li, Elliott, Richard M, Dong, C., Changjiang Dong   +16 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The effects of early syphilis on CD4 counts and HIV-1 RNA viral loads in blood and semen [PDF]

, 2005
Objective: To examine the effect of early syphilis on blood and semen plasma HIV-1 viral loads and CD4 counts.Methods: In a retrospective case-control study, blood plasma HIV-1 viral loads and CD4 counts in cases during early syphilis ( n = 63, 27 ...
Weller, IVD, Copas, AJ, Sadiq, ST, Edwards, SJ, Bennett, J, French, P, Kaye, S, McSorley, J, Kirk, S   +8 more
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

PAN RNA: transcriptional exhaust from a viral engine

Journal of Biomedical Science, 2020
Kaposi’s sarcoma-associated herpesvirus (KSHV), also designated human herpesvirus 8 (HHV-8), has been linked to Kaposi’s sarcoma, as well as to primary effusion lymphoma (PEL), and a subset of multicentric Castleman’s disease. KSHV genomes are maintained
Mel Campbell, Yoshihiro Izumiya
doaj   +1 more source