Results 101 to 110 of about 1,114,234 (207)

A comparison of viral RNA-dependent RNA polymerases

Current Opinion in Structural Biology, 2006
Genome replication in picornaviruses is catalyzed by a virally encoded RNA-dependent RNA polymerase, termed 3D. These viruses also use a small protein primer, named VPg, to initiate RNA replication. The recent explosion of structural information on picornaviral 3D polymerases has provided insights into the initiation of RNA synthesis and chain ...
Ferrer-Orta, Cristina, Arias, Armando, Escarmís, Cristina, Verdaguer, Núria   +3 more
openaire   +3 more sources

Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus

Nature Communications, 2017
Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-1 ...
Vincent Rincheval, Mickael Lelek, Elyanne Gault, Camille Bouillier, Delphine Sitterlin, Sabine Blouquit-Laye, Marie Galloux, Christophe Zimmer, Jean-François Eleouet, Marie-Anne Rameix-Welti   +9 more
doaj   +1 more source

dsRNA-Seq: Identification of Viral Infection by Purifying and Sequencing dsRNA

Viruses, 2019
RNA viruses are a major source of emerging and re-emerging infectious diseases around the world. We developed a method to identify RNA viruses that is based on the fact that RNA viruses produce double-stranded RNA (dsRNA) while replicating. Purifying and
Carolyn J. Decker, Halley R. Steiner, Laura L. Hoon-Hanks, James H. Morrison, Kelsey C. Haist, Alex C. Stabell, Eric M. Poeschla, Thomas E. Morrison, Mark D. Stenglein, Sara L. Sawyer, Roy Parker   +10 more
doaj   +1 more source

Promoting adherence to antiretroviral therapy: the experience from a primary care setting in Khayelitsha, South Africa. [PDF]

, 2004
OBJECTIVE: To describe the approach used to promote adherence to antiretroviral therapy (ART) and to present the outcomes in the first primary care public sector ART project in South Africa.
Asselman, V, Boulle, A, Coetzee, D, Goemaere, E, Hildebrand, K, Van Cutsem, G   +5 more
core   +1 more source

Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I

mBio, 2015
Stimulation of the antiviral response depends on the sensing of viral pathogen-associated molecular patterns (PAMPs) by specialized cellular proteins.
Jie Xu, Xiomara Mercado-López, Jennifer T. Grier, Won-keun Kim, Lauren F. Chun, Edward B. Irvine, Yoandris Del Toro Duany, Alison Kell, Sun Hur, Michael Gale, Arjun Raj, Carolina B. López   +11 more
doaj   +1 more source

TGF-β suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex.

PLoS Pathogens, 2015
Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined.
Guoxin Liang, Guangyan Liu, Kouichi Kitamura, Zhe Wang, Sajeda Chowdhury, Ahasan Md Monjurul, Kousho Wakae, Miki Koura, Miyuki Shimadu, Kazuo Kinoshita, Masamichi Muramatsu   +10 more
doaj   +1 more source

Pan-viral serology implicates enteroviruses in acute flaccid myelitis. [PDF]

, 2019
Since 2012, the United States of America has experienced a biennial spike in pediatric acute flaccid myelitis (AFM)1-6. Epidemiologic evidence suggests non-polio enteroviruses (EVs) are a potential etiology, yet EV RNA is rarely detected in cerebrospinal
Banerji, Debarko, Benson, Leslie, Bove, Riley, Briggs, Benjamin, Cheung, Carly K, Chitnis, Tanuja, Chiu, Charles Y, Chu, Victoria, Crawford, Emily D, DeRisi, Joseph L, Ding, Joy Z, Dominguez, Samuel R, Gelfand, Amy A, Glaser, Carol A, Gorman, Mark P, Hauser, Stephen L, Hawes, Isobel A, Johnson-Kerner, Bethany L, Khan, Lillian M, Konopka-Anstadt, Jennifer L, Krishnamoorthy, Kalpathy S, Lopez, Adriana S, Lyden, Amy, Marine, Rachel L, McMillan, Hugh J, Messacar, Kevin, Nash, Kendall, Ng, Terry Fei Fan, Nix, W Allan, O'Donovan, Brian D, Oberste, M Steven, Pak, John E, Ramachandran, Prashanth S, Ramesh, Akshaya, Sample, Hannah A, Schubert, Ryan D, Sit, Rene, Soldatos, Ariane, Sowa, Gavin M, Tan, Michelle, Tato, Cristina M, Wadford, Debra A, Wilson, Michael R, Wu, Wesley, Yen, Cynthia, Zorn, Kelsey C   +45 more
core  

DDX17 and viral infection

Virulence
DDX17 (DEAD-box RNA helicase 17) is an essential RNA helicase and regulatory ATPase in host cells, extensively involved in various cellular processes during viral infections, such as RNA splicing, transcriptional regulation, and post-transcriptional ...
Yuting Cheng, Ruohan Wang, Anping Wang, Zhi Wu, Wenfeng Jia, Huipeng Lu, Qingguo Wu, Shanyuan Zhu   +7 more
doaj   +1 more source

Class of {varphi}X174 Mutants Relatively Deficient in Synthesis of Viral RNA [PDF]

, 1974
Nonpermissive cells infected with {varphi}X174 gene D amber mutants synthesized some sixfold less viral RNA than permissive cells. The decrease was unaffected by increasing the multiplicity of infection and was a consequence of an overall decrease in all
Clements, J. Barklie, Sinsheimer, Robert L.   +1 more
core  

Banana plants use post-transcriptional gene silencing to control banana streak virus infection [PDF]

, 2013
Banana streak virus (BSV), the causative agent of banana streak disease, is a plant pararetrovirus belonging to the family Caulimoviridae, genus Badnavirus.
Chabannes, Matthieu, Duroy, Pierre-Olivier, Iskra Caruana, Marie-Line, Laboureau, Nathalie, Pooggin, Mikhail, Rajendran, Rajeswaran, Seguin, Jonathan   +6 more
core