Results 1 to 10 of about 1,593,705 (264)

Interactions of the Insect-Specific Palm Creek Virus with Zika and Chikungunya Viruses in Aedes Mosquitoes

Microorganisms, 2021
Palm Creek virus (PCV) is an insect-specific flavivirus that can interfere with the replication of mosquito-borne flaviviruses in Culex mosquitoes, thereby potentially reducing disease transmission.
Cassandra Koh, Annabelle Henrion-Lacritick, Lionel Frangeul, Maria-Carla Saleh   +3 more
doaj   +1 more source

Multifaceted contributions of Dicer2 to arbovirus transmission by Aedes aegypti

Cell Reports, 2023
Summary: Arthropod-borne viruses (arboviruses) transmitted by Aedes aegypti mosquitoes are an increasing threat to global health. The small interfering RNA (siRNA) pathway is considered the main antiviral immune pathway of insects, but its effective ...
Sarah Hélène Merkling, Anna Beth Crist, Annabelle Henrion-Lacritick, Lionel Frangeul, Elodie Couderc, Valérie Gausson, Hervé Blanc, Alexander Bergman, Artem Baidaliuk, Ottavia Romoli, Maria-Carla Saleh, Louis Lambrechts   +11 more
doaj   +1 more source

Combined VEGFR and MAPK pathway inhibition in angiosarcoma

Scientific Reports, 2021
Angiosarcoma is an aggressive malignancy of endothelial cells that carries a high mortality rate. Cytotoxic chemotherapy can elicit clinical responses, but the duration of response is limited.
Michael J. Wagner, Yasmin A. Lyons, Jean H. Siedel, Robert Dood, Archana S. Nagaraja, Monika Haemmerle, Lingegowda S. Mangala, Pritha Chanana, Alexander J. Lazar, Wei-Lien Wang, Vinod Ravi, Eric C. Holland, Anil K. Sood   +12 more
doaj   +1 more source

Ribosomal RNA (rRNA) sequences from 33 globally distributed mosquito species for improved metagenomics and species identification

eLife, 2023
Total RNA sequencing (RNA-seq) is an important tool in the study of mosquitoes and the RNA viruses they vector as it allows assessment of both host and viral RNA in specimens. However, there are two main constraints.
Cassandra Koh, Lionel Frangeul, Hervé Blanc, Carine Ngoagouni, Sébastien Boyer, Philippe Dussart, Nina Grau, Romain Girod, Jean-Bernard Duchemin, Maria-Carla Saleh   +9 more
doaj   +1 more source

Evidence For Long-Lasting Transgenerational Antiviral Immunity in Insects

Cell Reports, 2020
Summary: Transgenerational immune priming (TGIP) allows memory-like immune responses to be transmitted from parents to offspring in many invertebrates.
Juan A. Mondotte, Valérie Gausson, Lionel Frangeul, Yasutsugu Suzuki, Marie Vazeille, Vanesa Mongelli, Hervé Blanc, Anna-Bella Failloux, Maria-Carla Saleh   +8 more
doaj   +1 more source

Differential Small RNA Responses against Co-Infecting Insect-Specific Viruses in Aedes albopictus Mosquitoes

Viruses, 2020
The mosquito antiviral response has mainly been studied in the context of arthropod-borne virus (arbovirus) infection in female mosquitoes. However, in nature, both female and male mosquitoes are frequently infected with insect-specific viruses (ISVs ...
Lionel Frangeul, Hervé Blanc, Maria-Carla Saleh, Yasutsugu Suzuki   +3 more
doaj   +1 more source

Tudor-SN Promotes Early Replication of Dengue Virus in the Aedes aegypti Midgut

iScience, 2020
Summary: Diseases caused by mosquito-borne viruses have been on the rise for the last decades, and novel methods aiming to use laboratory-engineered mosquitoes that are incapable of carrying viruses have been developed to reduce pathogen transmission ...
Sarah Hélène Merkling, Vincent Raquin, Stéphanie Dabo, Annabelle Henrion-Lacritick, Hervé Blanc, Isabelle Moltini-Conclois, Lionel Frangeul, Hugo Varet, Maria-Carla Saleh, Louis Lambrechts   +9 more
doaj   +1 more source

The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs

Cell Death and Disease, 2023
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1; also known as deleted in oral cancer or DOC1) is a tumor suppressor gene known to play functional roles in both cell cycle regulation and in the epigenetic control of embryonic stem cell ...
Roberto Stabile, Mario Román Cabezas, Mathijs P. Verhagen, Francesco A. Tucci, Thierry P. P. van den Bosch, Maria J. De Herdt, Berdine van der Steen, Alex L. Nigg, Meng Chen, Cristina Ivan, Masayoshi Shimizu, Senada Koljenović, Jose A. Hardillo, C. Peter Verrijzer, Robert J. Baatenburg de Jong, George A. Calin, Riccardo Fodde   +16 more
doaj   +1 more source

Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts

Nature Communications, 2021
Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally ...
Veronica V. Rezelj, Lucía Carrau, Fernando Merwaiss, Laura I. Levi, Diana Erazo, Quang Dinh Tran, Annabelle Henrion-Lacritick, Valérie Gausson, Yasutsugu Suzuki, Djoshkun Shengjuler, Bjoern Meyer, Thomas Vallet, James Weger-Lucarelli, Veronika Bernhauerová, Avi Titievsky, Vadim Sharov, Stefano Pietropaoli, Marco A. Diaz-Salinas, Vincent Legros, Nathalie Pardigon, Giovanna Barba-Spaeth, Leonid Brodsky, Maria-Carla Saleh, Marco Vignuzzi   +23 more
doaj   +1 more source

Role of tissue-factor bearing extracellular vesicles released from ovarian cancer cells in platelet aggregation in vitro and venous thrombosis in mice

Thrombosis Update, 2021
Objective: Venous thromboembolism (VTE) contributes to morbidity and mortality in women with ovarian cancer. Underlying mechanisms of venous thrombosis in ovarian cancer are not well-understood. The aim of this study was to identify the potential role of
Tomoyuki Sasano, Min Soon Cho, Cristian Rodriguez-Aguayo, Emine Bayraktar, Mana Taki, Vahid Afshar-Kharghan, Anil K. Sood   +6 more
doaj   +1 more source