Results 31 to 40 of about 1,593,705 (264)

microRNA Therapeutics in Cancer — An Emerging Concept

EBioMedicine, 2016
MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding RNAs that negatively regulate protein coding gene and other non-coding transcripts expression.
Maitri Y. Shah, Alessandra Ferrajoli, Anil K Sood, Gabriel Lopez-Berestein, George A. Calin   +4 more
doaj   +1 more source

Construction and validation of prognostic nomogram for metaplastic breast cancer

Biomolecules & Biomedicine, 2022
In this study we aimed to develop nomogram models for predicting the overall survival (OS) and cancer-specific survival (CSS) of patients with metaplastic breast cancer (MBC). Data of patients diagnosed with MBC from 1973 to 2015 were collected from the
Yongfeng Li, Daobao Chen, Haojun Xuan, Mihnea P. Dragomir, George A. Calin, Xuli Meng, Meng Chen, Hongchuan Jin   +7 more
doaj   +1 more source

Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity [PDF]

, 2015
EC is supported by the Alexander von Humboldt Foundation, the German Federal Ministry for Education and Research, the Helmholtz Association, the Göran Gustafsson Foundation, the Swedish Research Council, the Kempe Foundation and Umeå University.
White, Malcolm F., Charpentier, Emmanuelle, White, Malcolm F, van der Oost, John, Richter, Hagen, Oost, John, van der, Charpentier, Emmanuelle,, White, Malcolm F; id_orcid   +7 more
core   +1 more source

Mal de Río Cuarto Virus Infection Triggers the Production of Distinctive Viral-Derived siRNA Profiles in Wheat and Its Planthopper Vector

Frontiers in Plant Science, 2017
Plant reoviruses are able to multiply in gramineae plants and delphacid vectors encountering different defense strategies with unique features. This study aims to comparatively assess alterations of small RNA (sRNA) populations in both hosts upon virus ...
Luis A. de Haro, Luis A. de Haro, Analía D. Dumón, María F. Mattio, Evangelina Beatriz Argüello Caro, Gabriela Llauger, Diego Zavallo, Hervé Blanc, Vanesa C. Mongelli, Graciela Truol, María-Carla Saleh, Sebastián Asurmendi, Sebastián Asurmendi, Mariana del Vas, Mariana del Vas   +14 more
doaj   +1 more source

miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities

Cells, 2023
MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological ...
Wilson Huang, Doru Paul, George A. Calin, Recep Bayraktar   +3 more
doaj   +1 more source

Microbiome composition modulates the lethal outcome of Drosophila A virus infection

Cellular and Molecular Life Sciences
Host-associated microbiomes can strongly influence viral infection outcomes, yet how minor variations in commensal bacterial composition modulate viral pathogenesis remain poorly understood.
Rubén­ González, Mauro Castelló-Sanjuán, Ottavia Romoli, Hervé Blanc, Hiroko Kobayashi, Jared Nigg, Maria-Carla Saleh   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Unlocking the potential of RNA interference as a therapeutic tool [PDF]

, 2009
The existence of an intrinsic biochemical pathway enabling specified regulation of gene expression was unheard of until the final years of the last decade.
Day, Philip JR, Ayers, Duncan, Day, Philip J R; id_orcid   +2 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source