Results 51 to 60 of about 495,459 (282)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Enhancing Chemotherapy by RNA Interference
BIO Integration, 2020 Small interfering RNA (siRNA) has shown tremendous potential for treating human diseases in the past decades. siRNA can selectively silence a pathological pathway through the targeting and degradation of a specific mRNA, significantly reducing the off ...
Shuwen Cao +5 more
doaj +1 more source
Management of pest insects and plant diseases by non-transformative RNAi [PDF]
, 2019 Since the discovery of RNA interference (RNAi), scientists have made significant progress towards the development of this unique technology for crop protection.
Avila dos Santos, Ericmar +5 more
core +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Limited impact of the siRNA pathway on transposable element expression in Aedes aegypti
BMC BiologyBackground Transposable elements (TEs) are DNA sequences that can change their position within a genome. In insects, small RNA pathways are central to the transcriptional and post-transcriptional regulation of TE expression.
Alexander Bergman +10 more
doaj +1 more source
FABP4 as a key determinant of metastatic potential of ovarian cancer
Nature Communications, 2018 In ovarian cancer, metastatic phenotype may impact surgical outcomes. Here, the authors show miR-409-3p regulates FABP4 which can increase metastatic potential of ovarian cancer, and treatment with DOPC nanoliposomes containing either miR-409--3p mimic ...
Kshipra M. Gharpure +27 more
doaj +1 more source
Author Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression
Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Rajesha Rupaimoole +28 more
doaj +1 more source
Short-interference RNAs: becoming medicines [PDF]
, 2015 RNA interference is a cellular mechanism by which small molecules of double stranded RNA modulate gene expression acting on the concentration and/or availability of a given messenger RNA.
Jiménez, Ana Isabel +2 more
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Suppression of Argonaute 2 Transcript Levels in Du182A Cells [PDF]
, 2018 RNA interference (RNAi) uses double-stranded RNA (dsRNA) molecules to degrade and suppress the transcript level of a complementary mRNA target1.
Featherston, Kyah +2 more
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