Results 51 to 60 of about 319,742 (303)
Unlocking the potential of RNA interference as a therapeutic tool [PDF]
, 2009 The existence of an intrinsic biochemical pathway enabling specified regulation of gene expression was unheard of until the final years of the last decade.
Day, Philip JR +2 more
core
RNA interference-mediated co-transcriptional gene silencing in fission yeast [PDF]
, 2012 In the last decade or so, RNA interference (RNAi) has gained unanticipated recognition in the fields of RNA biology and gene regulation. It exists in a wide variety of eukaryotic organisms, and various forms of RNAi are involved in diverse biological ...
Woolcock, Katrina Jane
core +1 more source
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing [PDF]
, 2010 We report that combining a DNA analog (2?F-ANA) with rigid RNA analogs [2?F-RNA and/or locked nucleic acid (LNA)] in siRNA duplexes can produce gene silencing agents with enhanced potency. The favored conformations of these two analogs are different, and
Alain, Tommy +9 more
core +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The RNA Polymerase II-associated factor 1 complex represses small-RNA-mediated heterochromatin formation and gene silencing [PDF]
, 2015 RNAi interference (RNAi) is a highly conserved regulatory mechanism employed by almost all Eukaryotes. With RNAi organisms can modulate the expression of endogenous genes and protect the integrity and identity of their genomes.
Kowalik, Katarzyna Maria
core +1 more source
EBioMedicine, 2019 Background: Investigations into the function of non-promoter DNA methylation have yielded new insights into the epigenetic regulation of gene expression.
Michael H. McGuire +8 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source