Results 61 to 70 of about 319,742 (303)

RNA interference-mediated antiviral defense in insects [PDF]

, 2018
Small interfering RNA (siRNA)-mediated RNA interference (RNAi) pathways are critical for the detection and inhibition of RNA virus replication in insects.
Mello, Craig C., Gammon, Don B.
core   +1 more source

Enhancing Chemotherapy by RNA Interference

BIO Integration, 2020
Small interfering RNA (siRNA) has shown tremendous potential for treating human diseases in the past decades. siRNA can selectively silence a pathological pathway through the targeting and degradation of a specific mRNA, significantly reducing the off ...
Shuwen Cao, Chunhao Lin, Shunung Liang, Chee Hwee Tan, Phei Er Saw, Xiaoding Xu   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Evidence of a tick RNAi pathway by comparative genomics and reverse genetics screen of targets with known loss-of-function phenotypes in Drosophila [PDF]

, 2009
Background The Arthropods are a diverse group of organisms including Chelicerata (ticks, mites, spiders), Crustacea (crabs, shrimps), and Insecta (flies, mosquitoes, beetles, silkworm).
Rodriguez Valle, Manuel, Lew-Tabor, AE, Doogan, VJ, Doogan, V.J, Roberto A Barrero, Vivienne J Doogan, Bruyeres, A.G., Bellgard, Matthew I., Valle, MR, Kurscheid, S., Guerrero, FD, Bellgard, M.I., Ulrike G Munderloh, Barrero, RA, Lew-Tabor, Ala E., Bruyeres, Anthea G., Doogan, Vivienne J., Kurscheid, S, Felix D Guerrero, Bruyeres, AG, Lew-Tabor, A.E., Manuel Rodriguez Valle, Anthea G Bruyeres, Guerrero, F.D., Matthew I Bellgard, Bellgard, MI, Munderloh, U.G., Munderloh, UG, Munderloh, Ulrike G., Rodriguez Valle, M., Sebastian Kurscheid, Kurscheid, Sebastian, Barrero, R.A., Ala E Lew-Tabor, Guerrero, Felix D., Barrero, Roberto A.   +35 more
core   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Limited impact of the siRNA pathway on transposable element expression in Aedes aegypti

BMC Biology
Background Transposable elements (TEs) are DNA sequences that can change their position within a genome. In insects, small RNA pathways are central to the transcriptional and post-transcriptional regulation of TE expression.
Alexander Bergman, Anna B. Crist, Hélène Lopez-Maestre, Hervé Blanc, Mauro Castelló-Sanjuán, Lionel Frangeul, Hugo Varet, Josquin Daron, Sarah H. Merkling, Maria-Carla Saleh, Louis Lambrechts   +10 more
doaj   +1 more source

FABP4 as a key determinant of metastatic potential of ovarian cancer

Nature Communications, 2018
In ovarian cancer, metastatic phenotype may impact surgical outcomes. Here, the authors show miR-409-3p regulates FABP4 which can increase metastatic potential of ovarian cancer, and treatment with DOPC nanoliposomes containing either miR-409--3p mimic ...
Kshipra M. Gharpure, Sunila Pradeep, Marta Sans, Rajesha Rupaimoole, Cristina Ivan, Sherry Y. Wu, Emine Bayraktar, Archana S. Nagaraja, Lingegowda S. Mangala, Xinna Zhang, Monika Haemmerle, Wei Hu, Cristian Rodriguez-Aguayo, Michael McGuire, Celia Sze Ling Mak, Xiuhui Chen, Michelle A. Tran, Alejandro Villar-Prados, Guillermo Armaiz Pena, Ragini Kondetimmanahalli, Ryan Nini, Pranavi Koppula, Prahlad Ram, Jinsong Liu, Gabriel Lopez-Berestein, Keith Baggerly, Livia S. Eberlin, Anil K. Sood   +27 more
doaj   +1 more source

Author Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Rajesha Rupaimoole, Sherry Y. Wu, Sunila Pradeep, Cristina Ivan, Chad V. Pecot, Kshipra M. Gharpure, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Michael McGuire, Behrouz Zand, Heather J. Dalton, Justyna Filant, Justin Bottsford Miller, Chunhua Lu, Nouara C. Sadaoui, Lingegowda S. Mangala, Morgan Taylor, Twan van den Beucken, Elizabeth Koch, Cristian Rodriguez-Aguayo, Li Huang, Menashe Bar-Eli, Bradly G. Wouters, Milan Radovich, Mircea Ivan, George A. Calin, Wei Zhang, Gabriel Lopez-Berestein, Anil K. Sood   +28 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

RNA interference [PDF]

BMJ, 2004
BRYAN E. FIGUEROA, ROBERT M. FRIEDLANDER
  +6 more sources