Results 1 to 10 of about 285,352 (309)
MMpred: functional miRNA – mRNA interaction analyses by miRNA expression prediction [PDF]
, 2012 Background: MicroRNA (miRNA) directed gene repression is an important mechanism of posttranscriptional regulation. Comprehensive analyses of how microRNA influence biological processes requires paired miRNA-mRNA expression datasets.
Wilson, Paul +2 more
core +8 more sources
Secreted miRNAs in the tripartite neuromuscular junction [PDF]
ExRNA, 2019 microRNAs are small, non-coding, single-stranded RNAs that can suppress mRNA translation at the posttranscriptional level by binding to imperfect complementary sequences on mRNA targets and then cause their degradation or hinder protein translation ...
Liangsheng Lu +6 more
doaj +1 more source
Initial function of microRNAs as a defence mechanism against invading organisms [PDF]
ExRNA, 2019 Background: Although microRNA (miRNA) regulation is widely considered as a mechanism to regulate gene expression in metazoans, plants and viruses, there are recent reports that show the interaction between viruses and their mammal hosts via miRNAs ...
Xiaoshuang Liu +5 more
doaj +1 more source
Journal of Allergy and Clinical Immunology, 2018 MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are crucial regulators of gene expression and promising candidates for biomarker development.
Thomas X. Lu, Marc E. Rothenberg
openaire +2 more sources
Stem Cell Research & Therapy, 2022 Background Anti-inflammatory polarized macrophages are reported to alleviate systemic lupus erythematosus (SLE). Our previous studies have demonstrated that exosomes from adipose-derived stem cells promote the anti-inflammatory polarization of ...
Mingchao Zhang +8 more
doaj +1 more source
Tumor-specific delivery of KRAS siRNA with iRGD-exosomes efficiently inhibits tumor growth [PDF]
ExRNA, 2019 Lung cancer is the major cause of cancer-related deaths globally. Mutant KRAS is a feature of 15–50% of lung cancer cases and represents one of the most prevalent oncogenic drivers in this disease.
Yu Zhou +5 more
doaj +1 more source
MicroRNA: MicroRNAs Reach out into Dendrites [PDF]
Current Biology, 2006 A recent study has shown that miR-134, a brain-specific microRNA, is present in dendrites where it represses the local synthesis of the protein kinase LimK1; this is a novel form of translational regulation in dendrites and may have important physiological implications.
Tai, H., Schuman, E.
openaire +3 more sources
Nature Communications, 2023 Renal tubular atrophy is a hallmark of chronic kidney disease. The study by Zhu et al. reveals the protective role of tubular polynucleotide phosphorylase (PNPT1) against renal atrophy by blocking the leakage of mitochondrial dsRNAs into cytoplasm where ...
Yujie Zhu +12 more
doaj +1 more source
Co-targeting of EGFR by co-expressed miRNA-193a-3p/−5p in lung cancer [PDF]
ExRNA, 2019 MicroRNAs (miRNAs) function as important oncogenes or tumor suppressors in each stage of cancer development. While previous studies focused on the individual miRNA and its specific target gene, the cooperative functions of miRNA-3p and miRNA-5p (miRNA-3p/
Kegan Zhu +8 more
doaj +1 more source
MicroRNA or Not MicroRNA? [PDF]
, 2011 The avalanche of next generation sequencing data has led to a rapid increase of annotated microRNAs in the last few years. Many of them are specific to individual species or rather narrow clades. A closer inspection of the current version of miRBase shows that dozens of entries conflict with other ncRNAs, in particular snoRNAs.With few exceptions ...
David Langenberger +5 more
openaire +2 more sources