Results 41 to 50 of about 245,684 (269)

The copper microRNAs [PDF]

New Phytologist, 2016
SummaryCopper (Cu) microRNAs are upregulated by Cu deficiency and mediate the post‐transcriptional downregulation of transcripts that encode Cu proteins, suggesting a role directly related to Cu. However, expression and phenotypic analyses of copper microRNA mutants and over‐expressors have suggested roles mainly in tolerance to abiotic stresses.
openaire   +2 more sources

miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression. [PDF]

, 2012
Acquired resistance to classical chemotherapeutics is a major obstacle in cancer treatment. Doxorubicin is frequently used in breast cancer therapy either as single-agent or in combination with other drugs like docetaxel and cyclophosphamide.
Oak, Prajakta S., Prajakta S. Oak (115995), Florian Kopp, Andreas Roidl, Kopp, Florian, Roidl, Andreas, Prajakta S Oak, Florian Kopp (115988), Ernst Wagner (60760), Andreas Roidl (116002), Wagner, Ernst, Ernst Wagner   +11 more
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MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma

, 2011
Background: MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies ...
Polta, Andreas, Kronenberger, Bernd, Peveling-Oberhag, Jan, Bernd Kronenberger, Haupenthal Jörg, Susser, Simone, Andreas Polta, Susser Simone, Welker, Martin, Piiper, Albrecht, Trojan Jörg, Jörg Trojan, Forestier, Nicole, Radeke, Heinfried H., Peveling-Oberhag Jan, Heinfried H Radeke, Verena Bihrer, Jan Peveling-Oberhag, Heinfried H. Radeke, Welker, Martin-Walter, Polta Andreas, Radeke Heinfried H., Nicole Forestier, von Wagner Michael, Kronenberger Bernd, Stefan Zeuzem, Friedrich-Rust Mireen, Oliver Waidmann, Friedrich-Rust, Mireen, Michael von Wagner, Sarrazin, Christoph, Radeke, Heinfried H, Zeuzem Stefan, Christoph Sarrazin, Martin Welker, Shi Ying, Jörg Haupenthal, von Wagner, Michael, Simone Susser, Forestier Nicole, Piiper Albrecht, Bihrer Verena, Bihrer, Verena, Haupenthal, Jörg, Welker Martin, Sarrazin Christoph, Shi, Ying, Peveling-Oberhag, Jan Franz-Josef, Mireen Friedrich-Rust, Waidmann Oliver, Waidmann, Oliver, Albrecht Piiper, Trojan, Jörg, Ying Shi, Wagner, Michael von, Zeuzem, Stefan   +55 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

MicroRNAs in Cholangiopathies [PDF]

Current Pathobiology Reports, 2014
Cholangiocytes, the cells lining bile ducts, comprise a small fraction of the total cellular component of the liver, yet perform the essential role of bile modification and transport of biliary and blood constituents. Cholangiopathies are a diverse group of biliary disorders with the cholangiocyte as the target cell; the etiopathogenesis of most ...
Steven P, O'Hara, Sergio A, Gradilone, Tetyana V, Masyuk, James H, Tabibian, Nicholas F, LaRusso   +4 more
openaire   +2 more sources

MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation [PDF]

, 2014
This work was funded by the Multiple Sclerosis Society. Tissue samples and associated clinical and neuropathological data were supplied by the UK MS Tissue ...
Kay, O., Reijerkerk, A., Hirst, MC, King-Robson, Josh, de Vries, HE, Michael, G.J., Male, DK, Reijerkerk, A, Reijerkerk, Arie, Sharrack, B, de Vries, Helga E., Romero, I.A., Baker, D., Kay, Oliver, Simpson, Julie E., Simpson, J.E., Romero, IA, Male, D.K., de Vries, H.E., Baker, David, King-Robson, J., Sharrack, B., King-Robson, J, Wu, D., Michael, GJ, Wu, Dongsheng, Wu, D, Simpson, JE, Lopez-Ramirez, Miguel Alejandro, Lopez-Ramirez, MA, Kay, O, Pryce, Gareth, Hirst, M.C., Baker, D, Male, David Kingsley, Romero, Ignacio Andres, Pryce, G, Pryce, G., Hirst, Mark C., Sharrack, Basil, Michael, Gregory J., Lopez-Ramirez, M.A.   +41 more
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Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

MicroRNAs in lupus [PDF]

Autoimmunity, 2014
Systemic lupus erythematosus is a prototypic autoimmune disease characterized by the production of an array of pathogenic autoantibodies, including high-affinity anti-dsDNA IgG antibodies, which play an important role in disease development and progression. Lupus preferentially affects women during their reproductive years. The pathogenesis of lupus is
Zan, Hong, Tat, Connie, Casali, Paolo
openaire   +4 more sources

A robust system for RNA interference in the chicken using a modified microRNA operon

, 2006
RNA interference (RNAi) provides an effective method to silence gene expression and investigate gene function. However, RNAi tools for the chicken embryo have largely been adapted from vectors designed for mammalian cells.
Wilson, Stuart A, Placzek, Marysia, Sacco, Melanie A., Sang, Helen M, McGrew, Michael J., Howell, Gareth R., Van Hateren, Nick J., Porteous, Victoria C, Manning, Elizabeth M, Porteous, Victoria C., Bangs, Fiona K, Bangs, Fiona K., Sacco, Melanie A, Nair, Venugopal K, Das, Raman M, McGrew, Mike; id_orcid, Das, Raman M; id_orcid, Van Hateren, Nick J, Storey, Kate G, Tickle, Cheryll, Farrell, Elizabeth R, Storey, Kate G., Wilson, Stuart A., Farrell, Elizabeth R., Halley, Pam A, Das, Raman M., Sang, Helen M., Howell, Gareth R, Manning, Elizabeth M., McGrew, Michael J, Ohyama, Kyoji, Nair, Venugopal K., Halley, Pam A.   +32 more
core   +1 more source