Redox Biology, 2023 Acute kidney injury (AKI) presents a daunting challenge with limited therapeutic options. To explore the contribution of N6-methyladenosine (m6A) in AKI development, we have investigated m6A-modified mRNAs within renal tubular cells subjected to injuries
Wenwen Yang +8 more
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Evaluation of Stem-Loop Reverse Transcription and Poly-A Tail Extension in MicroRNA Analysis of Body Fluids [PDF]
, 2014 MicroRNA has been demonstrated to be a viable tool for body fluid identification purposes in forensic casework. Stem-loop reverse transcription (slRT) is regularly used for cDNA synthesis from mature miRNA, along with poly-A tail extension.
Williams, Graham A. +3 more
core +1 more source
Considering the effect of stem-loop reverse transcription and quantitative PCR analysis of blood and saliva specific microRNA markers upon mixed body fluid stains [PDF]
, 2013 Forensic RNA analysis is gathering pace with reports of messenger RNA analysis being used in case work, and with microRNA being increasingly researched.
Uchimoto, M.L. +10 more
core +1 more source
Characterisation of body fluid specific microRNA markers by capillary electrophoresis [PDF]
, 2013 The characterisation of RNA molecules for the purpose of body fluid identification is currently a major field in forensic genetics; with a great deal of effort going towards the analysis of messenger RNA (mRNA).
World, Damien +6 more
core +1 more source
miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4
Protein & Cell, 2016 Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer (CRC). During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism ...
Yanqing Liu +16 more
doaj +1 more source
Emerging role of extracellular microRNAs and lncRNAs [PDF]
ExRNA, 2019 The discovery of extracellular non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has dramatically altered our understanding of the role RNA plays in organisms.
Geyu Zhou, Xi Chen
doaj +1 more source
Body fluid mixtures; resolution using forensic microRNA analysis [PDF]
, 2013 Body fluid identification is a crucial aspect of forensic biology; particularly in sexual assaults which is usually characterised as a mixture of body fluids.
World, Damien +5 more
core +1 more source
“MicroRNA Expression Profiling in human Subcutaneous Adipose Tissue” [PDF]
, 2008 MicroRNA are believed to be generally involved in more quantitative regulation of mammalian trait: therefore, mammalian conditions that have a strong genetic component and involve quantitative differences between the physiological and pathological ...
Castanò, Ilenia
core +1 more source
Viral infection and neurological disorders—potential role of extracellular nucleotides in neuroinflammation [PDF]
ExRNA, 2019 Neuroinflammation can be induced under several conditions including pathogen infection such as virus. As the main immune cells in brain, microglia activation plays a pivotal role in neuroinflammation by responding to the invading pathogens (viral DNA/RNA)
Liang Li +4 more
doaj +1 more source
Circulating microRNA, secreted microRNA and exogenous plant microRNA [PDF]
Journal of Translational Medicine, 2012 Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers. Here we demonstrate that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves and horses.
openaire +1 more source