Results 21 to 30 of about 245,684 (269)

Circulating microRNA, secreted microRNA and exogenous plant microRNA [PDF]

Journal of Translational Medicine, 2012
Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers. Here we demonstrate that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves and horses.
openaire   +1 more source

Comprehensive prediction of novel microRNA targets in Arabidopsis thaliana

, 2008
Alves jun. L, Niemeier S, Hauenschild A, Rehmsmeier M, Merkle T. Comprehensive prediction of novel microRNA targets in Arabidopsis thaliana. Nucleic Acids Research.
Ra Niemeier, Marc Rehmsmeier, Hauenschild, Arne, Niemeier, Sandra, Rehmsmeier, Marc, Leonardo Alves-junior, Arne Hauenschild, Merkle, Thomas, Thomas Merkle, Sandra Niemeier, Alves jun., Leonardo   +10 more
core   +1 more source

Pre-microRNA and Mature microRNA in Human Mitochondria

PLoS ONE, 2011
Because of the central functions of the mitochondria in providing metabolic energy and initiating apoptosis on one hand and the role that microRNA (miRNA) play in gene expression, we hypothesized that some miRNA could be present in the mitochondria for post-transcriptomic regulation by RNA interference.
Barrey, Eric, Saint-Auret, Gaelle, Bonnamy, Blandine, Damas, Dominique, Boyer, Orane, Gidrol, Xavier   +5 more
openaire   +5 more sources

MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival

, 2011
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
Hatton, CSR, Taylor Steve, Taylor, Stephen, Taylor, S, Lawrie Charles H, Saunders, NJ, Steve Taylor, Pezzella Francesco, Saunders Nigel J, Tramonti, D, Lawrie, CH, Wainscoat James S, Kusec, R, Pezzella, F, Tramonti Daniela, Nigel J Saunders, Hatton Christian SR, Chen, XH, Hatton, CS, Charles H Lawrie, Rajko Kušec, Littlewood, T, Erica Ballabio, Deborah Hay, Timothy Littlewood, Chi, J, Jacqueline Boultwood, Boultwood Jacqueline, Kušec Rajko, Jianxiang Chi, Chen Xiao-He, James S Wainscoat, Ballabio, E, Ballabio Erica, Chi Jianxiang, Xiao-He Chen, Littlewood Timothy, Francesco Pezzella, Christian SR Hatton, Wainscoat, JS, Hay Deborah, Pezzella, Francesco, Boultwood, Jacqueline, Hay, D, Boultwood, J, Daniela Tramonti   +45 more
core   +1 more source

Characterization of post-transcriptional regulatory network of RNA-binding proteins using computational predictions and deep sequencing data [PDF]

, 2013
This report is divided into three parts: Data Analysis, Mathematical Modeling and Conclusion and future directions. In the Data Analysis part, various methods and tools for characterizing the post-transcriptional regulatory networks of RNA-binding ...
Mohsen, Khorshid
core   +1 more source

microRNA and Cancer [PDF]

The AAPS Journal, 2010
MicroRNAs (miRNAs), a class of small, regulatory, non-coding RNA molecules, display aberrant expression patterns and functional abnormalities in human diseases including cancers. This review summarizes the abnormally expressed miRNAs in various types of human cancers, possible mechanisms underlying such abnormalities, and miRNA-modulated molecular ...
Mengfeng, Li, Jun, Li, Xiaofan, Ding, Mian, He, Shi-Yuan, Cheng   +4 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Target specificity and developmental functions of the let-7 microRNA [PDF]

, 2015
let-7 is a highly conserved microRNA(miRNA) with important functions in a wide variety of biological processes. In the nematode worm Caenorhabditis elegans (C. elegans) let-7 plays a crucial role in developmental timing, regulating temporal cell fates in
Ecsedi, Matyas
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source