Results 11 to 20 of about 285,352 (309)
Modulation of microRNA Activity by Semi-microRNAs [PDF]
Frontiers in Genetics, 2012 The ribonuclease Dicer plays a central role in the microRNA pathway by catalyzing the formation of 19-24-nucleotide (nt) long microRNAs. Subsequently incorporated into Argonaute 2 (Ago2) effector complexes, microRNAs are known to regulate messenger RNA (mRNA) translation.
Plante, Isabelle +4 more
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Regulation of Cardiac MicroRNAs by Cardiac MicroRNAs [PDF]
Circulation Research, 2013 Rationale: MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions.
Scot J, Matkovich +2 more
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In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis
Nature Communications, 2022 Management of ulcerative colitis can require a combination of treatments targeting different pathways. Here the authors design a therapy for ulcerative colitis based on a multitargeted genetic circuit to simultaneously target TNF-α, B7-1 and integrin α4,
Xinyan Zhou +10 more
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RNAhybrid: microRNA target prediction easy, fast, and flexible [PDF]
, 2006 Krüger J, Rehmsmeier M. RNAhybrid: microRNA target prediction easy, fast, and flexible. Nucleic Acids Research.
Krüger, Jan, Rehmsmeier, Marc
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Comprehensive prediction of novel microRNA targets in Arabidopsis thaliana [PDF]
, 2008 Alves jun. L, Niemeier S, Hauenschild A, Rehmsmeier M, Merkle T. Comprehensive prediction of novel microRNA targets in Arabidopsis thaliana. Nucleic Acids Research.
Ra Niemeier +10 more
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Annual Review of Pathology: Mechanisms of Disease, 2014 MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation, apoptosis, and migration.
Gianpiero, Di Leva +2 more
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Biogenesis and function of extracellular miRNAs [PDF]
ExRNA, 2019 Mature microRNAs (miRNAs) are 18–24-nucleotide non-coding RNAs with post-transcriptional regulatory functions and have been documented as an essential cornerstone of the genetic system.
Chihao Zhao, Xinlei Sun, Limin Li
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MicroRNAs and Metastasis [PDF]
Cancers, 2019 Metastasis, the development of secondary malignant growths at a distance from the primary site of a cancer, is associated with almost 90% of all cancer deaths, and half of all cancer patients present with some form of metastasis at the time of diagnosis. Consequently, there is a clear clinical need for a better understanding of metastasis.
Solé, Carla, Lawrie, Charles H.
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Serum microRNA Profiles Serve as Novel Biomarkers for Autoimmune Diseases
Frontiers in Immunology, 2018 Autoimmune diseases involve a complex dysregulation of immunity. Autoimmune diseases include many members [e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)], and most of them are classified according to what organs and tissues are ...
Fangfang Jin +6 more
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MicroRNAs in the Hypothalamus [PDF]
Neuroendocrinology, 2013 MicroRNAs (miRNAs) are short (∼22 nucleotides) non-coding ribonucleic acid (RNA) molecules that negatively regulate the expression of protein-coding genes. Posttranscriptional silencing of target genes by miRNA is initiated by binding to the 3′-untranslated regions of target mRNAs, resulting in specific cleavage and subsequent degradation of the mRNA ...
Meister, Björn +2 more
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