Results 51 to 60 of about 245,684 (269)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

MicroRNAs and cancer [PDF]

Journal of Internal Medicine, 2008
Abstract.The Nobel Prize in Medicine and Physiology was awarded to the RNA interference (RNAi) field in 2006 because of the huge therapeutic potential this technique harbours. However, the RNAi technology is based on a natural mechanism that utilizes short noncoding RNA molecules (microRNAs) to regulate gene expression.
openaire   +3 more sources

MicroRNA-encoded behavior in Drosophila [PDF]

, 2015
The relationship between microRNA (miRNA) regulation and the specification of behavior is only beginning to be explored.We found that mutation of a single miRNA locus (miR-iab4/iab8)inDrosophila larvae affects the animal’s capacity to correct its ...
Jamie Johnston (7583810), Johnston, J, Joao Picao-Osorio (16228022), Berni, J, Matthias Landgraf (37354), Picao-Osorio, J, Landgraf, M, Jimena Berni (7875149), Alonso, CR, Claudio Alonso (4462075)   +9 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

MicroRNA-mRNA network.

, 2016
microRNA/mRNA networks were constructed between the fifteen upregulated miRNAs and 150 overlapped mRNAs with using transcriptome expression data and predicted target genes from Targetscan, PITA, RNA22 and miRDB databases.
Ke Ma (260231), Shan Cui (3152124), Aiping Xu (3152121), Jin-Hui Wang (143676), Li Guo (171454)   +4 more
core   +1 more source

microRNA-767 and its binding site polymorphism in mTOR gene act as potential biomarkers for female reproductive cancers - supplementary material

, 2023
Supplementary Table 1: Demographic and histopathological parameters of cases and controls.Supplementary Table 2: Primers for microRNA-767, U6 and Tetra-ARMS PCR primers for mTOR(rs2536) SNPSupplementary Table 3: PCR conditions for tetra arms ...
Ishrat Mahjabeen (846545), Kashaf Bibi (17079994), Nida Sarosh Ashraf (17080000), Maria Fazal Ul Haq (17080003), Mahmood Akhtar Kayani (783301), Azhar Mehmood (12966920), Rabia Shafique (14659740), Sumaira Fida Abbasi (17080006), Nadia Saeed (12966914), Muhammad Rizwan (536386), Farah Kalsoom (17079997)   +10 more
core   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

“MicroRNA Expression Profiling in human Subcutaneous Adipose Tissue”

, 2008
MicroRNA are believed to be generally involved in more quantitative regulation of mammalian trait: therefore, mammalian conditions that have a strong genetic component and involve quantitative differences between the physiological and pathological ...
Castanò, Ilenia
core