Results 51 to 60 of about 285,352 (309)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

miREE: miRNA Recognition Elements Ensemble [PDF]

, 2011
Background Computational methods for microRNA target prediction are a fundamental step to understand the miRNA role in gene regulation, a key process in molecular biology. In this paper we present miREE, a novel microRNA target prediction tool.
Enrico Macii, Acquaviva, Andrea, Paula H Reyes-Herrera, Macii Enrico, Acquaviva Andrea, REYES HERRERA, PAULA HELENA, Andrea Acquaviva, Elisa Ficarra, Ficarra, Elisa, Reyes-Herrera Paula H, Macii, Enrico, Ficarra Elisa, Reyes Herrera Ph   +12 more
core   +1 more source

Crosstalk between KRAS and miRNA in cancer [PDF]

ExRNA
Kirsten RAS viral oncogene homolog (KRAS) is one of the most frequently mutated oncogenes in human cancers. Its mutations result in constitutive activation of the protein, which drives the mitogen-activated protein kinase (MAPK) and phosphoinositide 3 ...
Ruoming Shen, Yixuan Zhao, Qin Sheng, Ying Sun, Yanbo Wang   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Identification of an allatostatin C signaling system in mollusc Aplysia

Scientific Reports, 2022
Neuropeptides, as pervasive intercellular signaling molecules in the CNS, modulate a variety of behavioral systems in both protostomes and deuterostomes.
Hui-Min Jiang, Zhe Yang, Ying-Yu Xue, Hui-Ying Wang, Shi-Qi Guo, Ju-Ping Xu, Ya-Dong Li, Ping Fu, Xue-Ying Ding, Ke Yu, Wei-Jia Liu, Guo Zhang, Jian Wang, Hai-Bo Zhou, Abraham J. Susswein, Jian Jing   +15 more
doaj   +1 more source

microRNAs and cartilage [PDF]

Journal of Orthopaedic Research, 2013
ABSTRACTmicroRNAs are small non‐coding RNAs that in the last decade have emerged as overarching regulators of gene expression. Their abundance, ability to repress a large number of target genes and overlapping target specificity indicate a complex network of interactions that is still being defined.
Gary, Gibson, Hiroshi, Asahara
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Acute responses of circulating microRNAs to low-volume sprint interval cycling

Frontiers in Physiology, 2015
Low-volume high-intensity interval training is an efficient and practical method of inducing physiological responses in various tissues to develop physical fitness and may also change the expression of circulating microRNAs (miRNAs).
Shu Fang eCui, Shu Fang eCui, Wei eLi, Jie eNiu, Chen Yu eZhang, Chen Yu eZhang, Xi eChen, Xi eChen, Ji Zheng eMa, Ji Zheng eMa, Ji Zheng eMa   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Application Prospect of MicroRNA in Skin Wound Age Estimation

Fayixue Zazhi, 2021
Wound age estimation is one of the major tasks in forensic practice. However, relatively accurate estimation of the wound age is still a conundrum and research spotlight world-widely. Studies show that microRNAs (miRNAs) are involved in the whole process
CHENG Jian, SUO Long-long, WANG Lin-lin, ZHAO Rui, GUAN Da-wei   +4 more
doaj   +1 more source