Results 71 to 80 of about 285,352 (309)

Vascular microRNAs

Current Drug Targets, 2010
MicroRNAs are endogenously expressed small non-coding RNAs that regulate gene expression on the posttranscriptional level. During the last years microRNAs have emerged as key regulators of several physiological and pathophysiological processes in the vascular wall.
Angelika Bonauer, Reinier A. Boon, Stefanie Dimmeler   +2 more
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Characterization of post-transcriptional regulatory network of RNA-binding proteins using computational predictions and deep sequencing data [PDF]

, 2013
This report is divided into three parts: Data Analysis, Mathematical Modeling and Conclusion and future directions. In the Data Analysis part, various methods and tools for characterizing the post-transcriptional regulatory networks of RNA-binding ...
Mohsen, Khorshid
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

microRNA-mRNA pairs with a significant inverse correlation in vulvar melanoma.

, 2023
microRNA-mRNA pairs with a significant inverse correlation in vulvar melanoma.
Colin D. Angell (16469560), William E. Carson III (11372435), Alejandro A. Gru (11372432), Casey Ren (15179108), Maribelle Moufawad (11372429), Mallory J. DiVincenzo (11372420), Catherine Chung (680172), Floor J. Backes (16469563), Kari Ring (16469566), Zoe Barricklow (11372423), Paolo Fadda (765567), Anne Mills (70199), Craig Slingluff (4399051), Lorena P. Suarez-Kelly (11552092), Lianbo Yu (144585)   +14 more
core   +1 more source

microRNAs and oligometastasis

Aging, 2015
Most cancer-related deaths occur as a result of metastases – tumor cells derived from the primary tumor which colonize distant sites. Metastases widely differ in their behavior which contributes to the heterogeneity in clinical manifestations of metastatic disease.
Nikolai N, Khodarev, Sean P, Pitroda, Ralph R, Weichselbaum   +2 more
openaire   +2 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Target specificity and developmental functions of the let-7 microRNA [PDF]

, 2015
let-7 is a highly conserved microRNA(miRNA) with important functions in a wide variety of biological processes. In the nematode worm Caenorhabditis elegans (C. elegans) let-7 plays a crucial role in developmental timing, regulating temporal cell fates in
Ecsedi, Matyas
core   +1 more source

scZGA: a novel model based on ZINB distribution and graph attention for scRNA-seq data clustering

BMC Bioinformatics
Background Identifying different cell types is a prerequisite step in the analysis of single-cell RNA sequencing (scRNA-seq) data, with clustering being a common technique utilized for this purpose.
Yansheng Kan, Yuling Liu, Jiacheng Pan, Ruochen Wang, Chen-Yu Zhang, Zhen Zhou   +5 more
doaj   +1 more source