Results 21 to 30 of about 319,742 (303)

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]

, 2010
For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Andrzej Dziembowski, Rafal Tomecki, Tomecki, Rafał, Dziembowski, Andrzej   +3 more
core   +1 more source

The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs

Cell Death and Disease, 2023
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1; also known as deleted in oral cancer or DOC1) is a tumor suppressor gene known to play functional roles in both cell cycle regulation and in the epigenetic control of embryonic stem cell ...
Roberto Stabile, Mario Román Cabezas, Mathijs P. Verhagen, Francesco A. Tucci, Thierry P. P. van den Bosch, Maria J. De Herdt, Berdine van der Steen, Alex L. Nigg, Meng Chen, Cristina Ivan, Masayoshi Shimizu, Senada Koljenović, Jose A. Hardillo, C. Peter Verrijzer, Robert J. Baatenburg de Jong, George A. Calin, Riccardo Fodde   +16 more
doaj   +1 more source

RNA interference is responsible for reduction of transgene expression after Sleeping Beauty transposase mediated somatic integration. [PDF]

, 2012
Integrating non-viral vectors based on transposable elements are widely used for genetically engineering mammalian cells in functional genomics and therapeutic gene transfer.
Anja Ehrhardt, Ehrhardt, Anja, Christina Rauschhuber, Christina Rauschhuber (167226), Anja Ehrhardt (167232), Ehrhardt Anja, Rauschhuber Christina, Rauschhuber, Christina   +7 more
core   +1 more source

Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts

Nature Communications, 2021
Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally ...
Veronica V. Rezelj, Lucía Carrau, Fernando Merwaiss, Laura I. Levi, Diana Erazo, Quang Dinh Tran, Annabelle Henrion-Lacritick, Valérie Gausson, Yasutsugu Suzuki, Djoshkun Shengjuler, Bjoern Meyer, Thomas Vallet, James Weger-Lucarelli, Veronika Bernhauerová, Avi Titievsky, Vadim Sharov, Stefano Pietropaoli, Marco A. Diaz-Salinas, Vincent Legros, Nathalie Pardigon, Giovanna Barba-Spaeth, Leonid Brodsky, Maria-Carla Saleh, Marco Vignuzzi   +23 more
doaj   +1 more source

Role of tissue-factor bearing extracellular vesicles released from ovarian cancer cells in platelet aggregation in vitro and venous thrombosis in mice

Thrombosis Update, 2021
Objective: Venous thromboembolism (VTE) contributes to morbidity and mortality in women with ovarian cancer. Underlying mechanisms of venous thrombosis in ovarian cancer are not well-understood. The aim of this study was to identify the potential role of
Tomoyuki Sasano, Min Soon Cho, Cristian Rodriguez-Aguayo, Emine Bayraktar, Mana Taki, Vahid Afshar-Kharghan, Anil K. Sood   +6 more
doaj   +1 more source

The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cells [PDF]

, 2008
The NS3 protein of the tenuivirus rice hoja blanca virus (RHBV) has previously been shown to represent the viral RNA interference (RNAi) suppressor and is active in both plant and insect cells by binding short interfering RNAs (siRNAs) in vitro.
Hemmes, J.C., Schnettler, E., Goldbach, R.W., Prins, M.W.   +3 more
core   +1 more source

Pseudogenes, RNAs and new reproducibility norms

eLife, 2020
The partial success of a study to reproduce experiments that linked pseudogenes and cancer proves that understanding RNA networks is more complicated than expected.
George A Calin
doaj   +1 more source

Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype

Cell Reports, 2021
Summary: Tumor and stromal interactions consist of reciprocal signaling through cytokines, growth factors, direct cell-cell interactions, and extracellular vesicles (EVs).
Shaolin Ma, Michael H. McGuire, Lingegowda S. Mangala, Sanghoon Lee, Elaine Stur, Wen Hu, Emine Bayraktar, Alejandro Villar-Prados, Cristina Ivan, Sherry Y. Wu, Akira Yokoi, Santosh K. Dasari, Nicholas B. Jennings, Jinsong Liu, Gabriel Lopez-Berestein, Prahlad Ram, Anil K. Sood   +16 more
doaj   +1 more source

RNA Interference and Small RNA Analysis [PDF]

Cold Spring Harbor Protocols, 2019
Small silencing RNAs have provided powerful reverse genetics tools and have opened new areas of research. This introduction describes the use of RNAi to suppress expression of individual genes for loss-of-function analysis. It also summarizes methods for measuring specific and global changes in small RNA expression, as well as methods to inhibit the ...
Chengjian, Li, Phillip D, Zamore
openaire   +2 more sources

An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]

, 2007
RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid, Stuart, Kenneth, Ernst, Nancy Lewis, Fleck, Michele, Babbarwal, Vinod Kumar   +4 more
core   +1 more source