Results 21 to 30 of about 1,593,705 (264)

RNA interference is responsible for reduction of transgene expression after Sleeping Beauty transposase mediated somatic integration. [PDF]

, 2012
Integrating non-viral vectors based on transposable elements are widely used for genetically engineering mammalian cells in functional genomics and therapeutic gene transfer.
Anja Ehrhardt, Ehrhardt, Anja, Christina Rauschhuber, Christina Rauschhuber (167226), Anja Ehrhardt (167232), Ehrhardt Anja, Rauschhuber Christina, Rauschhuber, Christina   +7 more
core   +2 more sources

Virus-derived DNA drives mosquito vector tolerance to arboviral infection

Nature Communications, 2016
Mosquitoes tolerate long-lasting viral infections, which makes them efficient vectors for human viral diseases. Here, the authors show that the tolerance of Aedesmosquitoes to infection with dengue or chikungunya viruses depends on the production of ...
Bertsy Goic, Kenneth A. Stapleford, Lionel Frangeul, Aurélien J. Doucet, Valérie Gausson, Hervé Blanc, Nidia Schemmel-Jofre, Gael Cristofari, Louis Lambrechts, Marco Vignuzzi, Maria-Carla Saleh   +10 more
doaj   +1 more source

RNA interference in marine and freshwater sponges [PDF]

, 2011
Background: The marine sponge Tethya wilhelma and the freshwater sponge Ephydatia muelleri are emerging model organisms to study evolution, gene regulation, development, and physiology in non-bilaterian animal systems. Thus far, functional methods (i.e.,
Posfai, Dora, Knight, Scott W., Nickel, Michael, Haen, Karri M., Lavrov, Dennis V., Danka, Elizabeth S., Hill, April L., Hammel, Jörg U., Wörheide, Gert, Cieniewicz, Brandon, Rivera, Ajna S., Winters, Ian P., Hill, Malcolm S.   +12 more
core   +1 more source

Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancerResearch in context

EBioMedicine, 2018
Background: Circulating miRNAs are known to play important roles in intercellular communication. However, the effects of exosomal miRNAs on cells are not fully understood.
Pinar Kanlikilicer, Recep Bayraktar, Merve Denizli, Mohammed H. Rashed, Cristina Ivan, Burcu Aslan, Rahul Mitra, Kubra Karagoz, Emine Bayraktar, Xinna Zhang, Cristian Rodriguez-Aguayo, Amr Ahmed El-Arabey, Nermin Kahraman, Seyda Baydogan, Ozgur Ozkayar, Michael L. Gatza, Bulent Ozpolat, George A. Calin, Anil K. Sood, Gabriel Lopez-Berestein   +19 more
doaj   +1 more source

An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]

, 2007
RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid, Stuart, Kenneth, Ernst, Nancy Lewis, Fleck, Michele, Babbarwal, Vinod Kumar   +4 more
core   +1 more source

PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axisResearch in context

EBioMedicine, 2019
Background: Inflammatory mediator prostaglandin E2–prostaglandin E2 receptor EP3 (PTGER3) signaling is critical for tumor-associated angiogenesis, tumor growth, and chemoresistance. However, the mechanism underlying these effects in ovarian cancer is not
Cristian Rodriguez-Aguayo, Emine Bayraktar, Cristina Ivan, Burcu Aslan, Junhua Mai, Guangan He, Lingegowda S. Mangala, Dahai Jiang, Archana S. Nagaraja, Bulent Ozpolat, Arturo Chavez-Reyes, Mauro Ferrari, Rahul Mitra, Zahid H. Siddik, Haifa Shen, Xianbin Yang, Anil K. Sood, Gabriel Lopez-Berestein   +17 more
doaj   +1 more source

A genome‐scale screen reveals context‐dependent ovarian cancer sensitivity to miRNA overexpression

Molecular Systems Biology, 2015
Large‐scale molecular annotation of epithelial ovarian cancer (EOC) indicates remarkable heterogeneity in the etiology of that disease. This diversity presents a significant obstacle against intervention target discovery.
Benjamin B Shields, Chad V Pecot, Hua Gao, Elizabeth McMillan, Malia Potts, Christa Nagel, Scott Purinton, Ying Wang, Cristina Ivan, Hyun Seok Kim, Robert J Borkowski, Shaheen Khan, Cristian Rodriguez‐Aguayo, Gabriel Lopez‐Berestein, Jayanthi Lea, Adi Gazdar, Keith A Baggerly, Anil K Sood, Michael A White   +18 more
doaj   +1 more source

Modeling recursive RNA interference. [PDF]

PLoS Computational Biology, 2008
An important application of the RNA interference (RNAi) pathway is its use as a small RNA-based regulatory system commonly exploited to suppress expression of target genes to test their function in vivo.
Wallace F Marshall
doaj   +1 more source

A functional genomic analysis of cell morphology using RNA interference [PDF]

, 2003
Background: The diversity of metazoan cell shapes is influenced by the dynamic cytoskeletal network. With the advent of RNA-interference (RNAi) technology, it is now possible to screen systematically for genes controlling specific cell-biological ...
Coulson, A., Echeverri C, Coulson, A, Perrimon N, Kiger AA, Coulson A, Jones, MR, Perrimon, Norbert, Jones, S, Echeverri, C., Jones MR, Baum, B., Jones, M.R., Baum, B, Baum B, Kiger, AA, Perrimon, N., Echeverri, C, Jones, S., Jones S, Kiger, A.A., MR Jones, N Perrimon, S Jones, B Baum, AA Kiger, A Coulson, C Echeverri   +27 more
core   +1 more source

Chromosome-wide analysis of gene function by RNA interference in the african trypanosome. [PDF]

, 2006
Trypanosomatids of the order Kinetoplastida are major contributors to global disease and morbidity, and understanding their basic biology coupled with the development of new drug targets represents a critical need.
J. Hayes-Sinclair, Field, Mark C, Shawcross, Emma, D. Horn, Hayes-Sinclair, Jamie, Field, Mark C., K. Gull, P. Veazey, Horn, David, E. Chambers, Redmond, Seth, Matthews, Keith; id_orcid, Veazey, Paul, M. Carrington, S. Redmond, Subramaniam, Chandra, Horn, David; id_orcid, C. Subramaniam, K. Matthews, Gull, Keith, Chambers, Emma, Carrington, Mark, M. C. Field, Matthews, Keith   +23 more
core   +1 more source