Results 21 to 30 of about 1,508,120 (294)

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]

, 2010
For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
core   +3 more sources

A fungal Argonaute interferes with RNA interference [PDF]

Nucleic Acids Research, 2018
Small RNA (sRNA)-mediated gene silencing phenomena, exemplified by RNA interference (RNAi), require a unique class of proteins called Argonautes (AGOs). An AGO protein typically forms a protein-sRNA complex that contributes to gene silencing using the loaded sRNA as a specificity determinant. Here, we show that MoAGO2, one of the three AGO genes in the
Nguyen, Quyet, Iritani, Akihide, Ohkita, Shuhei, Vu, Ba V., Yokoya, Kana, Matsubara, Ai, Ikeda, Ken-ichi, Suzuki, Nobuhiro, Nakayashiki, Hitoshi   +8 more
openaire   +4 more sources

Differential Small RNA Responses against Co-Infecting Insect-Specific Viruses in Aedes albopictus Mosquitoes

Viruses, 2020
The mosquito antiviral response has mainly been studied in the context of arthropod-borne virus (arbovirus) infection in female mosquitoes. However, in nature, both female and male mosquitoes are frequently infected with insect-specific viruses (ISVs ...
Lionel Frangeul, Hervé Blanc, Maria-Carla Saleh, Yasutsugu Suzuki   +3 more
doaj   +1 more source

Delivery of RNA Interference [PDF]

Cell Cycle, 2006
Over the last few years, RNA Interference (RNAi), a naturally occurring mechanism of gene regulation conserved in plant and mammalian cells, has opened numerous novel opportunities for basic research across the field of biology. While RNAi has helped accelerate discovery and understanding of gene functions, it also has great potential as a therapeutic ...
Charles X, Li, Amy, Parker, Ellen, Menocal, Shuanglin, Xiang, Laura, Borodyansky, Johannes H, Fruehauf   +5 more
openaire   +2 more sources

Tudor-SN Promotes Early Replication of Dengue Virus in the Aedes aegypti Midgut

iScience, 2020
Summary: Diseases caused by mosquito-borne viruses have been on the rise for the last decades, and novel methods aiming to use laboratory-engineered mosquitoes that are incapable of carrying viruses have been developed to reduce pathogen transmission ...
Sarah Hélène Merkling, Vincent Raquin, Stéphanie Dabo, Annabelle Henrion-Lacritick, Hervé Blanc, Isabelle Moltini-Conclois, Lionel Frangeul, Hugo Varet, Maria-Carla Saleh, Louis Lambrechts   +9 more
doaj   +1 more source

RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]

, 2013
Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Jo Milner, Simon J Allison, Milner, J., Allison, Simon J., Milner, Jo   +4 more
core   +1 more source

RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease. [PDF]

, 2010
Ribonucleases play important roles in the RNA interference (RNAi) pathway. The Dicer endonuclease converts double-stranded (ds)RNA into small interfering (si)RNA and the Slicer endonuclease, as a component of the RNA induced silencing complex (RISC ...
Louise E. Kemp, Kawahara, Taemi, Horn, David, Horn, David; id_orcid, Kemp, Louise E, Sam Alsford, Taemi Kawahara, Alsford, Sam, Kemp, Louise E., David Horn   +9 more
core   +1 more source

The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs

Cell Death and Disease, 2023
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1; also known as deleted in oral cancer or DOC1) is a tumor suppressor gene known to play functional roles in both cell cycle regulation and in the epigenetic control of embryonic stem cell ...
Roberto Stabile, Mario Román Cabezas, Mathijs P. Verhagen, Francesco A. Tucci, Thierry P. P. van den Bosch, Maria J. De Herdt, Berdine van der Steen, Alex L. Nigg, Meng Chen, Cristina Ivan, Masayoshi Shimizu, Senada Koljenović, Jose A. Hardillo, C. Peter Verrijzer, Robert J. Baatenburg de Jong, George A. Calin, Riccardo Fodde   +16 more
doaj   +1 more source

Using RNA interference to identify genes required for RNA interference [PDF]

Proceedings of the National Academy of Sciences, 2002
RNA interference (RNAi) is a phenomenon in which double-stranded RNA (dsRNA) silences endogenous gene expression. By injecting pools of dsRNAs into Caenorhabditis elegans , we identified a dsRNA that acts as a potent suppressor of the RNAi mechanism.
Nathaniel R, Dudley, Jean-Claude, Labbé, Bob, Goldstein   +2 more
openaire   +2 more sources

RNA interference targets arbovirus replication in Culicoides cells [PDF]

, 2013
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms.
Varela, Mariana, Esther Schnettler, Ratinier, Maxime, Shaw, Andrew, Palmarini, Massimo, Kohl, Alain, Mariana Varela, Mick Watson, Elliott, Richard M., Alain Kohl, Maxime Ratinier, McFarlane, Melanie, Shaw, Andrew E., Elliott, Richard, Richard M, Massimo Palmarini, Schnettler, Esther, E. Shaw, Watson, Mick, A Alain Kohla, Melanie Mcfarlane   +20 more
core   +1 more source