Results 21 to 30 of about 288,613 (251)
Pseudogenes, RNAs and new reproducibility norms
eLife, 2020 The partial success of a study to reproduce experiments that linked pseudogenes and cancer proves that understanding RNA networks is more complicated than expected.
George A Calin
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Cell Reports, 2021 Summary: Tumor and stromal interactions consist of reciprocal signaling through cytokines, growth factors, direct cell-cell interactions, and extracellular vesicles (EVs).
Shaolin Ma +16 more
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RNA Interference and Small RNA Analysis [PDF]
Cold Spring Harbor Protocols, 2019 Small silencing RNAs have provided powerful reverse genetics tools and have opened new areas of research. This introduction describes the use of RNAi to suppress expression of individual genes for loss-of-function analysis. It also summarizes methods for measuring specific and global changes in small RNA expression, as well as methods to inhibit the ...
Chengjian, Li, Phillip D, Zamore
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Virus-derived DNA drives mosquito vector tolerance to arboviral infection
Nature Communications, 2016 Mosquitoes tolerate long-lasting viral infections, which makes them efficient vectors for human viral diseases. Here, the authors show that the tolerance of Aedesmosquitoes to infection with dengue or chikungunya viruses depends on the production of ...
Bertsy Goic +10 more
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EBioMedicine, 2018 Background: Circulating miRNAs are known to play important roles in intercellular communication. However, the effects of exosomal miRNAs on cells are not fully understood.
Pinar Kanlikilicer +19 more
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EBioMedicine, 2019 Background: Inflammatory mediator prostaglandin E2–prostaglandin E2 receptor EP3 (PTGER3) signaling is critical for tumor-associated angiogenesis, tumor growth, and chemoresistance. However, the mechanism underlying these effects in ovarian cancer is not
Cristian Rodriguez-Aguayo +17 more
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RNA Interference for Viral Infections [PDF]
Current Drug Targets, 2012 The treatment of viral infections has relied on pre-emptive vaccination or use of a limited range of anti-viral drugs. However, the majority of viruses have no available drugs and treatment is merely supportive. RNA interference (RNAi) offers the ability to directly and rapidly treat virus infections via the targeting of viral genes.
Blake, Stephen J. +2 more
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A genome‐scale screen reveals context‐dependent ovarian cancer sensitivity to miRNA overexpression
Molecular Systems Biology, 2015 Large‐scale molecular annotation of epithelial ovarian cancer (EOC) indicates remarkable heterogeneity in the etiology of that disease. This diversity presents a significant obstacle against intervention target discovery.
Benjamin B Shields +18 more
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Construction and validation of prognostic nomogram for metaplastic breast cancer
Biomolecules & Biomedicine, 2022 In this study we aimed to develop nomogram models for predicting the overall survival (OS) and cancer-specific survival (CSS) of patients with metaplastic breast cancer (MBC). Data of patients diagnosed with MBC from 1973 to 2015 were collected from the
Yongfeng Li +7 more
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