Results 71 to 80 of about 2,102,458 (307)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome.

PLoS Pathogens, 2011
Viruses have to encapsidate their own genomes during the assembly process. For most RNA viruses, there are sequences within the viral RNA and virion proteins needed for high efficiency of genome encapsidation.
Shuyuarn F Yu, Phillip Lujan, Dana L Jackson, Michael Emerman, Maxine L Linial   +4 more
doaj   +1 more source

An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]

, 2013
Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Darren M. Gowers (485354), Jack O Phillips, Anastasia J Callaghan, Vincent, H., Andrew R. Pickford (485355), Adam J Roberts, Louise E. Butt (485353), Stone, Carlanne, Charlotte E. Mardle (485352), Henderson, Charlotte, Adam J. Roberts (485350), Pickford, Andy, Carlanne M Stone, Roberts, Adam J., Butt, Louise, Charlotte A Henderson, Louise E Butt, Anastasia J. Callaghan (485356), Helen A Vincent, Charlotte E Mardle, Callaghan, Anastasia, Carlanne M. Stone (485351), Phillips, Jack, Jack O. Phillips (485348), Charlotte A. Henderson (485349), Gowers, Darren, Mardle, C., Andrew R Pickford, Helen A. Vincent (485347), Darren M Gowers, Henderson Charlotte A., Mardle Charlotte E., Callaghan Anastasia J., Pickford Andrew R., Phillips Jack O., Butt Louise E., Gowers Darren M., Vincent Helen A., Roberts Adam J., Stone Carlanne M.   +39 more
core   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication [PDF]

, 2014
Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA ...
Atkinson, N J, Simmonds, Peter, Atkinson, Nicky J., Evans, David J., Witteveldt, Jeroen, Evans, D. J., Evans, David J.; id_orcid   +6 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Genome transcription/translation of segmented, negative-strand RNA viruses [PDF]

, 2011
The requirements for alignment of capped RNA leader sequences along the viral genome during influenza transcription initiation (“cap-snatching”) have long been an enigma.
Geerts-Dimitriadou, C.
core  

Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules [PDF]

, 2010
The tospovirus NSs protein was previously shown to suppress the antiviral RNA silencing mechanism in plants. Here the biochemical analysis of NSs proteins from different tospoviruses, using purified NSs or NSs containing cell extracts, is described.
Kormelink, R.J.M., Rik Huismann, Esther Schnettler, Rob Goldbach, Goldbach, R., Marcel Prins, Goldbach, R.W., Kormelink, R., Hemmes, H., Prins, M., Huismann, R., Hans Hemmes, Huisman, R., Hemmes, J.C., Schnettler, E., Richard Kormelink, Prins, M.W.   +16 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source