Results 71 to 80 of about 2,786,263 (356)

Influence of viral genes on the cell-to-cell spread of RNA silencing [PDF]

The turnip crinkle virus-based vector TCV–GFPDCP had been devised previously to study cell-to-cell and long-distance spread of virus-induced RNA silencing.
Hong, Yiguo, Zhou, Yu, Ryabov, Eugene V., Zhang, Xuemei   +3 more
core   +1 more source

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence [PDF]

, 2004
Discrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and ...
Evans, David J, Simmonds, Peter, Tuplin, Andrew, Tuplin, A, Evans, DJ, Simmonds, P   +5 more
core   +1 more source

Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding

Cell Discovery, 2022
Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level IgG antibodies and higher regulatory T (Treg ...
Xiaohua Tang, Rui Sun, Weigang Ge, Tingting Mao, Liujia Qian, Chongquan Huang, Zhouyang Kang, Qi Xiao, Meng Luo, Qiushi Zhang, Sainan Li, Hao Chen, Wei Liu, Bingjie Wang, Shufei Li, Xiaoling Lin, Xueqin Xu, Huanzheng Li, Lianpeng Wu, Jianyi Dai, Huanhuan Gao, Lu Li, Tian Lu, Xiao Liang, Xue Cai, Guan Ruan, Fei Xu, Yan Li, Yi Zhu, Ziqing Kong, Jianping Huang, Tiannan Guo   +31 more
doaj   +1 more source

Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication

Journal of Experimental Medicine, 2016
Khan et al. demonstrate that the lower female reproductive tract is exceptionally vulnerable to infection by LCMV and Zika virus, as intravaginal exposure to these RNA viral pathogens elicits a dampened antiviral immune response.
Shahzada Khan, Erik M. Woodruff, M. Trapecar, Krystal A. Fontaine, Ashley Ezaki, Timothy C. Borbet, M. Ott, Shomyseh Sanjabi   +7 more
semanticscholar   +1 more source

Molecular Bases of Viral RNA Targeting by Viral Small Interfering RNA-Programmed RISC [PDF]

Journal of Virology, 2007
ABSTRACT RNA silencing is conserved in a broad range of eukaryotes and operates in the development and maintenance of genome integrity in many organisms. Plants have adapted this system for antiviral defense, and plant viruses have in turn developed mechanisms to suppress RNA silencing.
Pantaleo, V., Szittya, G., Burgyán, J.
openaire   +3 more sources

The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cells

, 2008
The NS3 protein of the tenuivirus rice hoja blanca virus (RHBV) has previously been shown to represent the viral RNA interference (RNAi) suppressor and is active in both plant and insect cells by binding short interfering RNAs (siRNAs) in vitro.
Hemmes, J.C., Schnettler, E., Goldbach, R.W., Prins, M.W.   +3 more
core   +1 more source

Structures and Functions of Viral 5′ Non-Coding Genomic RNA Domain-I in Group-B Enterovirus Infections

Viruses, 2020
Group-B enteroviruses (EV-B) are ubiquitous naked single-stranded positive RNA viral pathogens that are responsible for common acute or persistent human infections.
Marie Glenet, Laetitia Heng, Domitille Callon, Anne-Laure Lebreil, Paul-Antoine Gretteau, Yohan Nguyen, Fatma Berri, Laurent Andreoletti   +7 more
doaj   +1 more source

Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Nature Communications, 2020
The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics.
A. Shannon, B. Selisko, N. Le, Johanna Huchting, F. Touret, G. Piorkowski, Véronique Fattorini, F. Ferron, E. Decroly, C. Meier, B. Coutard, O. Peersen, B. Canard   +12 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Nucleocapsid protein captures DDX5 and RNMT facilitating viral RNA synthesis and viral protein translation for coronavirus replication

mBio
Coronaviruses (CoVs) hijack host RNA-binding proteins (RBPs) to facilitate their replication, but the viral proteins and host RBDs that participate in the synthesis of viral RNA and protein are unclear.
Yuchang Liu, Ning Kong, Xinyu Yang, Wenzhen Qin, Yahe Wang, Chen Wang, He Sun, Jiarui Wang, Ao Gao, Dongfang Zheng, Wu Tong, Hai Yu, Hao Zheng, Guangzhi Tong, Tongling Shan   +14 more
doaj   +1 more source