Results 31 to 40 of about 2,786,263 (356)

Viral suppression of RNA silencing [PDF]

Science China Life Sciences, 2012
يلعب إسكات الجينات (إسكات الحمض النووي الريبي) دورًا أساسيًا في الدفاع المضاد للفيروسات في النباتات والفطريات واللافقاريات. تقوم الفيروسات بتشفير البروتينات التي تمنع إسكات الجينات لمواجهة دفاع المضيف. تم تحديد المثبطات الفيروسية لإسكات الحمض النووي الريبي (RSVs) من جميع الفيروسات النباتية تقريبًا التي تولد وبعض فيروسات الحشرات والثدييات. كشفت الدراسات
Lin Jiang, Chunhong Wei, Yang Li
openaire   +2 more sources

Perspectives on Viral RNA Genomes and the RNA Folding Problem

Viruses, 2020
Viral RNA genomes change shape as virus particles disassemble, form replication complexes, attach to ribosomes for translation, evade host defense mechanisms, and assemble new virus particles.
Susan J. Schroeder
doaj   +1 more source

Molecular basis of specific viral RNA recognition and 5′-end capping by the Chikungunya virus nsP1

Cell Reports, 2022
Summary: Many viruses encode RNA-modifying enzymes to edit the 5′ end of viral RNA to mimic the cellular mRNA for effective protein translation, genome replication, and evasion of the host defense mechanisms.
Kuo Zhang, Michelle Cheok Yien Law, Trinh Mai Nguyen, Yaw Bia Tan, Melissa Wirawan, Yee-Song Law, Lak Shin Jeong, Dahai Luo   +7 more
doaj   +1 more source

TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS

Journal of Virology, 2018
Activation of innate immunity is essential for host cells to restrict the spread of invading viruses and other pathogens. MAVS plays a critical role in innate immune response to RNA viral infection. In this study, we demonstrated that TRIM21 targets MAVS
Binbin Xue, Huiyi Li, Mengmeng Guo, Jingjing Wang, Yan Xu, Xuan Zou, Rilin Deng, Guangdi Li, Haizhen Zhu   +8 more
semanticscholar   +1 more source

Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase [PDF]

, 2011
The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein that is crucial for the life cycle of the virus, as it catalyses both transcription of viral mRNAs and replication of the
Brennan, Benjamin, Richard M. Elliott, Li, Ping, Ping Li, Elliott, Richard M., Benjamin Brennan   +5 more
core   +1 more source

RNA Synthesis and Capping by Non-segmented Negative Strand RNA Viral Polymerases: Lessons From a Prototypic Virus

Frontiers in Microbiology, 2019
Non-segmented negative strand (NNS) RNA viruses belonging to the order Mononegavirales are highly diversified eukaryotic viruses including significant human pathogens, such as rabies, measles, Nipah, and Ebola.
T. Ogino, T. Green
semanticscholar   +1 more source

RNA Silencing and Plant Viral Diseases

Molecular Plant-Microbe Interactions, 2012
RNA silencing plays a critical role in plant resistance against viruses, with multiple silencing factors participating in antiviral defense. Both RNA and DNA viruses are targeted by the small RNA-directed RNA degradation pathway, with DNA viruses being ...
Ming-Bo Wang, Chikara Masuta, Neil A. Smith, Hanako Shimura   +3 more
doaj   +1 more source

Neuroinflammation During RNA Viral Infections

Annual Review of Immunology, 2019
Neurotropic RNA viruses continue to emerge and are increasingly linked to diseases of the central nervous system (CNS) despite viral clearance. Indeed, the overall mortality of viral encephalitis in immunocompetent individuals is low, suggesting ...
R. Klein, Charise Garber, K. Funk, H. Salimi, A. Soung, Marlene Kanmogne, Sindhu Manivasagam, S. Agner, Matthew D. Cain   +8 more
semanticscholar   +1 more source

Virus-derived DNA drives mosquito vector tolerance to arboviral infection

Nature Communications, 2016
Mosquitoes tolerate long-lasting viral infections, which makes them efficient vectors for human viral diseases. Here, the authors show that the tolerance of Aedesmosquitoes to infection with dengue or chikungunya viruses depends on the production of ...
Bertsy Goic, Kenneth A. Stapleford, Lionel Frangeul, Aurélien J. Doucet, Valérie Gausson, Hervé Blanc, Nidia Schemmel-Jofre, Gael Cristofari, Louis Lambrechts, Marco Vignuzzi, Maria-Carla Saleh   +10 more
doaj   +1 more source

RNA Structural Elements of Hepatitis C Virus Controlling Viral RNA Translation and the Implications for Viral Pathogenesis

Viruses, 2012
Hepatitis C virus (HCV) genome multiplication requires the concerted action of the viral RNA, host factors and viral proteins. Recent studies have provided information about the requirement of specific viral RNA motifs that play an active role in the ...
Encarnación Martinez-Salas, David Piñeiro   +1 more
doaj   +1 more source