Results 21 to 30 of about 2,786,263 (356)

Poly(rC)-Binding Protein 1 Limits Hepatitis C Virus Virion Assembly and Secretion

Viruses, 2022
The hepatitis C virus (HCV) co-opts numerous cellular elements, including proteins, lipids, and microRNAs, to complete its viral life cycle. The cellular RNA-binding protein, poly(rC)-binding protein 1 (PCBP1), was previously reported to bind to the 5 ...
Sophie E. Cousineau, Marylin Rheault, Selena M. Sagan   +2 more
doaj   +1 more source

Non-viral vectors for RNA delivery

Journal of Controlled Release, 2022
RNA-based therapy is a promising and potential strategy for disease treatment by introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering RNA (siRNA), microRNA (miRNA) or antisense oligonucleotides (ASO) to modulate gene ...
Yi Yan, Xiao-Yu Liu, An Lu, Xiangyu Wang, Lindong Jiang, Jiancheng Wang   +5 more
semanticscholar   +1 more source

A discontinuous RNA platform mediates RNA virus replication: building an integrated model for RNA-based regulation of viral processes. [PDF]

PLoS Pathogens, 2009
Plus-strand RNA viruses contain RNA elements within their genomes that mediate a variety of fundamental viral processes. The traditional view of these elements is that of local RNA structures.
Baodong Wu, Judit Pogany, Hong Na, Beth L Nicholson, Peter D Nagy, K Andrew White   +5 more
doaj   +1 more source

The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4 / UL5 Transcripts

mBio, 2021
Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire of drugs, often ...
Ana Cristina Gonzalez-Perez, Markus Stempel, Emanuel Wyler, Christian Urban, Antonio Piras, Thomas Hennig, Sabina Ganskih, Yuanjie Wei, Albert Heim, Markus Landthaler, Andreas Pichlmair, Lars Dölken, Mathias Munschauer, Florian Erhard, Melanie M. Brinkmann   +14 more
doaj   +1 more source

Nucleocapsid Structure of Negative Strand RNA Virus

Viruses, 2020
Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis ...
Ming Luo, James Ross Terrell, Shelby Ashlyn Mcmanus   +2 more
doaj   +1 more source

Profiling Selective Packaging of Host RNA and Viral RNA Modification in SARS-CoV-2 Viral Preparations

Frontiers in Cell and Developmental Biology, 2022
Viruses package host RNAs in their virions which are associated with a range of functions in the viral life cycle. Previous transcriptomic profiling of host RNA packaging mostly focused on retroviruses.
Noah Peña, Wen Zhang, Christopher Watkins, Mateusz Halucha, Hala Alshammary, Matthew M. Hernandez, Matthew M. Hernandez, Wen-Chun Liu, Wen-Chun Liu, Randy A. Albrecht, Randy A. Albrecht, Adolfo Garcia-Sastre, Adolfo Garcia-Sastre, Adolfo Garcia-Sastre, Adolfo Garcia-Sastre, Viviana Simon, Viviana Simon, Viviana Simon, Viviana Simon, Christopher Katanski, Tao Pan, Tao Pan   +21 more
doaj   +1 more source

Viral noncoding RNAs

Uirusu, 2009
Many lines of recent evidence indicate that non-coding RNAs including micro RNAs (miRNAs) and small interfering RNAs (siRNAs) play an important role in the control of gene expression in diverse cellular processes and in defense responses against molecular parasites such as viruses and transposons.
IWAKAWA, Hiro-oki, OKUNO, Testuro
openaire   +3 more sources

A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]

, 2008
The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad, Elliot, R., Evans, David John, Evans, D., Armstrong, V, Tuplin, Andrew, Evans, D.J., Struthers, Madeleine, Struthers, M., Elliott, Richard M., Diviney, S., Tuplin, A., Armstrong, V., Struthers, M, Simmonds, Peter, Elliott, Richard Michael, Armstrong, Victoria, Tuplin, A, Evans, David J., Simmonds, P., Diviney, S, Elliott, R.M., Simmonds, P   +22 more
core   +1 more source

The influence of viral RNA secondary structure on interactions with innate host cell defences [PDF]

, 2013
RNA viruses infecting vertebrates differ fundamentally in their ability to establish persistent infections with markedly different patterns of transmission, disease mechanisms and evolutionary relationships with their hosts.
Blundell, Richard, Richard Blundell, Nora McFadden, Joris J. Maarleveld, Maarleveld, Joris J, Evans, David J, Simmonds, Peter, Jeroen Witteveldt, Maarleveld, Joris J., David J. Evans, McFadden, Nora, Peter Simmonds, Evans, David J., Witteveldt, Jeroen   +13 more
core   +1 more source

Regulation of RNA Virus Processes by Viral Genome Structure

Proceedings, 2020
The genomes of RNA viruses contain a variety of RNA sequences and structures that regulate different steps in virus reproduction. Events that are controlled by RNA elements include (i) the translation of viral proteins, (ii) the replication of viral RNA ...
K. Andrew White
doaj   +1 more source