Results 31 to 40 of about 266,128 (263)

Predictors of HIV Viral Load Suppression After Enhanced Adherence Counseling, Nekemte, Ethiopia

Journal of Epidemiology and Global Health
Background Enhanced adherence counseling refers to the counseling intervention for Human Immunodeficiency Virus (HIV) patients with an elevated viral load result, a viral load of > 1000 copies/ml, on a routine or need-based viral load test.
Yohannis Mosisa, Adisu Ewunetu, Kitesa Biresa Duftu, Bayise Biru, Debelo Diriba, Adisu Tafari Shama, Melese Lemi, Getahun Fetensa, Bikila Regassa Feyisa   +8 more
doaj   +1 more source

Use of multi-trait and random regression models to identify genetic variation in tolerance to porcine reproductive and respiratory syndrome virus

Genetics Selection Evolution, 2017
Background A host can adopt two response strategies to infection: resistance (reduce pathogen load) and tolerance (minimize impact of infection on performance).
Graham Lough, Hamed Rashidi, Ilias Kyriazakis, Jack C. M. Dekkers, Andrew Hess, Melanie Hess, Nader Deeb, Antti Kause, Joan K. Lunney, Raymond R. R. Rowland, Han A. Mulder, Andrea Doeschl-Wilson   +11 more
doaj   +1 more source

Understanding HIV Viral Load [PDF]

Canadian Journal of Public Health, 2008
This paper provides an overview of HIV viral loads in blood and genital fluids and how these relate to HIV transmission during sexual activity. Current knowledge around HIV viral loads and transmission are then discussed in relation to HIV disclosure laws in Canada.
Patrick, O'Byrne, Paul A, MacPherson
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Evaluation of HIV viral load turnaround time in Moshi, Tanzania

Journal of Infection in Developing Countries, 2022
Introduction: Viral load measurement is an important gold standard for monitoring anti-retroviral treatment among people living with human immunodeficiency virus.
Elizabeth L Moirana, Eva Prosper Muro, Ireen Eliah Kiwelu, James Kimaro, Rachel Manongi, Zahra Theilgaard, Terese L Katzenstein   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

HPV viral load predicts immune exhaustion and prognosis in cervical neoplasia

Frontiers in Immunology
ObjectivePersistent infection with high−risk human papillomavirus (HPV) is the primary cause of cervical cancer; however, the prognostic role of HPV viral load and its association with the tumor immune microenvironment remain incompletely understood ...
Yibo Guo, Yuanrui Liu, Yongjian He, Yuzhao Zhang, Ling Li, Weiguo Lu, Zhanfeng Zhang   +6 more
doaj   +1 more source

Initial viral load and the outcomes of SARS [PDF]

Canadian Medical Association Journal, 2004
Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus. It may progress to respiratory failure, and a significant proportion of patients die. Preliminary data suggest that a high viral load of the SARS coronavirus is associated with adverse outcomes in the intensive care unit, but the relation of viral load to survival is unclear.We ...
Chan, KH, Peiris, JSM, Poon, LLM, Hung, IFN, Yuen, KY, Tse, DMW, Law, KI, Ng, PW, Sim, TC, Ng, WL, Chan, VL, Tang, BSF, Leung, WS, Wong, MML, Chan, KS, Cheng, VCC, Chu, CM   +16 more
openaire   +4 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source