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HIV reservoir in HIV patients

Туберкулез и болезни лёгких, 2019
An HIV reservoir is a collection of HIV DNA in target cells in an HIV-infected person. HIV reservoir in patients with HIV infection prevents eradication of the pathogen and cure of the disease.
E. I. Veselova, G. D. Kaminskiy, A. G. Samoylova, I. A. Vasilyeva   +3 more
doaj   +3 more sources

Neutralizing the HIV Reservoir [PDF]

Cell, 2014
Halper-Stromberg et al. use a humanized mouse model to demonstrate that broadly neutralizing antibodies, when administered with a combination of HIV latency activators, can reduce persistent HIV reservoirs, as measured by plasma virus rebound. Their results support the use of broadly neutralizing antibodies in HIV-reservoir-purging strategies.
Marsden, Matthew D, Zack, Jerome A
openaire   +4 more sources

Blood Center Testing Allows the Detection and Rapid Treatment of Acute and Recent HIV Infection

Viruses, 2022
Blood donations in South Africa are tested for HIV RNA using individual donation NAT (ID-NAT), allowing detection and rapid antiretroviral therapy (ART) of acute HIV infections.
Karin van den Berg, Marion Vermeulen, Sonia Bakkour, Mars Stone, Genevieve Jacobs, Cynthia Nyoni, Coreen Barker, Christopher McClure, Darryl Creel, Eduard Grebe, Nareg Roubinian, Ute Jentsch, Brian Custer, Michael P. Busch, Edward L. Murphy, on behalf of the Recipient Epidemiology and Donor Evaluation Study (REDS)-III South Africa International Program   +15 more
doaj   +1 more source

Tissue reservoirs of HIV [PDF]

Current Opinion in HIV and AIDS, 2016
Tissue reservoirs of HIV may promote the persistent immunopathology responsible for non-AIDS morbidity and data support multifocal reactivation from tissues as the source of viral rebound during antiretroviral therapy (ART) interruption. The heterogeneity of tissue reservoirs and incomplete knowledge about their composition are obstacles to an HIV cure.
Wong, Joseph K, Yukl, Steven A
openaire   +4 more sources

CD32+CD4+ T Cells Are Highly Enriched for HIV DNA and Can Support Transcriptional Latency

Cell Reports, 2020
Summary: The HIV latent reservoir forms the major hurdle to an HIV cure. The discovery of CD32 as marker of this reservoir has aroused much interest, but subsequent reports have challenged this finding. Here, we observe a positive correlation between the
Gilles Darcis, Neeltje A. Kootstra, Berend Hooibrink, Thijs van Montfort, Irma Maurer, Kevin Groen, Suzanne Jurriaans, Margreet Bakker, Carine van Lint, Ben Berkhout, Alexander O. Pasternak   +10 more
doaj   +1 more source

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

mBio, 2022
Human immunodeficiency virus type 1 (HIV-1) can integrate viral DNA into host cell chromosomes to establish a long-term stable latent reservoir, which is a major obstacle to cure HIV-1 infection. The characteristics of the HIV-1 latent reservoir have not
Wanying Zhang, Mo Zhou, Cancan Chen, Shiyu Wu, Lilin Wang, Baijin Xia, Jun Liu, Xiancai Ma, Ting Pan, Hui Zhang, Linghua Li, Bingfeng Liu   +11 more
doaj   +1 more source

CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir

mBio, 2022
HIV infects long-lived CD4 memory T cells, establishing a latent viral reservoir that necessitates lifelong antiretroviral therapy (ART). How this reservoir is formed so quickly after infection remains unclear.
Thomas A. Packard, Roland Schwarzer, Eytan Herzig, Deepashri Rao, Xiaoyu Luo, Johanne H. Egedal, Feng Hsiao, Marek Widera, Judd F. Hultquist, Zachary W. Grimmett, Ronald J. Messer, Nevan J. Krogan, Steven G. Deeks, Nadia R. Roan, Ulf Dittmer, Kim J. Hasenkrug, Warner C. Greene   +16 more
doaj   +1 more source

Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays

Viruses, 2022
Significant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment (ART)-free remission and cure for persons living with HIV-1 are being made with the advent of broadly neutralizing antibodies and very early ART in perinatal ...
Priya Khetan, Yufeng Liu, Adit Dhummakupt, Deborah Persaud   +3 more
doaj   +1 more source

HIV in the Brain: Identifying Viral Reservoirs and Addressing the Challenges of an HIV Cure

Vaccines, 2021
Advances in antiretroviral therapy have prolonged the life of people living with HIV and diminished the level of virus in these individuals. Yet, HIV quickly rebounds after disruption and/or cessation of treatment due to significant cellular and ...
Michelle K. Ash, Lena Al-Harthi, Jeffrey R. Schneider   +2 more
doaj   +1 more source

Predicting Post-treatment HIV Remission: Does Size of the Viral Reservoir Matter?

Frontiers in Microbiology, 2021
Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) replication and improves immune function. However, due to the persistence of long-lived HIV reservoirs, therapy interruption almost inevitably leads to a fast viral ...
Alexander O. Pasternak, Christina K. Psomas, Ben Berkhout   +2 more
doaj   +1 more source