Туберкулез и болезни лёгких, 2019 An HIV reservoir is a collection of HIV DNA in target cells in an HIV-infected person. HIV reservoir in patients with HIV infection prevents eradication of the pathogen and cure of the disease.
E. I. Veselova +3 more
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Identification of distinct HIV reservoir phenotypes and associated immune landscapes [PDF]
JCI InsightVirally suppressed people with HIV (PWH) remain at risk for developing comorbidities due to chronic inflammation with one potential contributor being the HIV reservoir Associations between the CD4 reservoir and inflammation have been extensively ...
Ruoyu Wang +9 more
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Inhibition of TIGIT on NK cells improves their cytotoxicity and HIV reservoir eradication potential [PDF]
mBioThe latent human immunodeficiency virus (HIV) reservoir presents the biggest obstacle to curing HIV chronic infection. Consequently, finding novel strategies to control the HIV reservoir is critical.
Yue Wang +11 more
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HIV in the Brain: Identifying Viral Reservoirs and Addressing the Challenges of an HIV Cure
Vaccines, 2021 Advances in antiretroviral therapy have prolonged the life of people living with HIV and diminished the level of virus in these individuals. Yet, HIV quickly rebounds after disruption and/or cessation of treatment due to significant cellular and ...
Michelle K. Ash +2 more
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Applications and limitations of the passenger hypothesis for HIV reservoir persistence and cure [PDF]
Journal of VirologyAntiretroviral therapy (ART) suppresses HIV replication in people living with HIV (PWH), but a persistent population of reservoir cells prevents cure. Reservoir cells are mostly anatomically dispersed, latently infected CD4+ T cells harboring one copy of
Joshua T. Schiffer +4 more
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Analysis of the effect of HDAC inhibitors on the formation of the HIV reservoir [PDF]
mBioThe HIV reservoir is more dynamic than previously thought with around 70% of the latent reservoir originating from viruses circulating within 1 year of the initiation of antiretroviral therapy (ART).
Lijun Ling +13 more
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Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size [PDF]
Scientific ReportsThe elimination of the latent viral reservoir remains the main barrier in the quest for a cure for people with HIV (PWH). The administration of latency reversal agents (LRA) at antiretroviral treatment (ART) initiation could improve the effectiveness of ...
Erick De La Torre Tarazona +17 more
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Dynamics of HIV DNA reservoir seeding in a cohort of superinfected Kenyan women. [PDF]
PLoS Pathogens, 2020 A reservoir of HIV-infected cells that persists despite suppressive antiretroviral therapy (ART) is the source of viral rebound upon ART cessation and the major barrier to a cure.
Mark D Pankau +11 more
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Neutralizing the HIV Reservoir [PDF]
Cell, 2014 Halper-Stromberg et al. use a humanized mouse model to demonstrate that broadly neutralizing antibodies, when administered with a combination of HIV latency activators, can reduce persistent HIV reservoirs, as measured by plasma virus rebound. Their results support the use of broadly neutralizing antibodies in HIV-reservoir-purging strategies.
Marsden, Matthew D, Zack, Jerome A
openaire +4 more sources
The HIV-1 latent reservoir is largely sensitive to circulating T cells
eLife, 2020 HIV-1-specific CD8+ T cells are an important component of HIV-1 curative strategies. Viral variants in the HIV-1 reservoir may limit the capacity of T cells to detect and clear virus-infected cells.
Joanna A Warren +17 more
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