Results 11 to 20 of about 35,436 (198)

HIV reservoir in HIV patients

Туберкулез и болезни лёгких, 2019
An HIV reservoir is a collection of HIV DNA in target cells in an HIV-infected person. HIV reservoir in patients with HIV infection prevents eradication of the pathogen and cure of the disease.
E. I. Veselova, G. D. Kaminskiy, A. G. Samoylova, I. A. Vasilyeva   +3 more
doaj   +3 more sources

The reservoir of latent HIV

Frontiers in Cellular and Infection Microbiology, 2022
The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV is unable to be recognized by the body’s immune system. Currently, the widely adopted antiretroviral therapy (ART) is also unble to eliminate it, thus hindering the ...
Chuanyun Li, Chen Dexi
exaly   +4 more sources

Peering into the HIV reservoir [PDF]

Reviews in Medical Virology, 2018
SummaryThe main obstacle to HIV eradication is the establishment of a long‐term persistent HIV reservoir. Although several therapeutic approaches have been developed to reduce and eventually eliminate the HIV reservoir, only a few have achieved promising results.
Marcial Garcia, Norma Rallon, JOSÉ Benito   +2 more
exaly   +3 more sources

A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size. [PDF]

PLoS Pathogens, 2023
The major barrier to an HIV cure is the HIV reservoir: latently-infected cells that persist despite effective antiretroviral therapy (ART). There have been few cohort-based studies evaluating host genomic or transcriptomic predictors of the HIV reservoir.
Ashok K Dwivedi, Germán G Gornalusse, David A Siegel, Alton Barbehenn, Cassandra Thanh, Rebecca Hoh, Kristen S Hobbs, Tony Pan, Erica A Gibson, Jeffrey Martin, Frederick Hecht, Christopher Pilcher, Jeffrey Milush, Michael P Busch, Mars Stone, Meei-Li Huang, Julieta Reppetti, Phuong M Vo, Claire N Levy, Pavitra Roychoudhury, Keith R Jerome, Florian Hladik, Timothy J Henrich, Steven G Deeks, Sulggi A Lee   +24 more
doaj   +2 more sources

Inhibition of TIGIT on NK cells improves their cytotoxicity and HIV reservoir eradication potential [PDF]

mBio
The latent human immunodeficiency virus (HIV) reservoir presents the biggest obstacle to curing HIV chronic infection. Consequently, finding novel strategies to control the HIV reservoir is critical.
Yue Wang, Yidi Li, Jiaqi Chen, Chenxi Guo, Xiaowen Yu, Zining Zhang, Yajing Fu, Xiaoxu Han, Qinghai Hu, Haibo Ding, Hong Shang, Yongjun Jiang   +11 more
doaj   +2 more sources

Applications and limitations of the passenger hypothesis for HIV reservoir persistence and cure [PDF]

Journal of Virology
Antiretroviral therapy (ART) suppresses HIV replication in people living with HIV (PWH), but a persistent population of reservoir cells prevents cure. Reservoir cells are mostly anatomically dispersed, latently infected CD4+ T cells harboring one copy of
Joshua T. Schiffer, Joseph C. Mudd, Annukka A. R. Antar, Adam M. Spivak, Daniel B. Reeves   +4 more
doaj   +2 more sources

Measuring the HIV-1 reservoir [PDF]

Nature Reviews Microbiology, 2019
The description of a method to measure the HIV-1 reservoir that quantifies intact and defective proviruses.
exaly   +3 more sources

The HIV reservoir landscape in elite controllers. [PDF]

Curr Opin HIV AIDS
Purpose of review In this review, we intend to define the main characteristics of the elite controller reservoir, exploring into its heterogeneity, which goes hand in hand with the different progression phenotypes within elite controllers. Recent findings
Moral-Turón C, Antequera-Martínez M, Ruiz-Mateos E.   +2 more
europepmc   +3 more sources

New Frontiers in Measuring and Characterizing the HIV Reservoir

Frontiers in Microbiology, 2019
A cure for HIV infection remains elusive due to the persistence of replication-competent HIV proviral DNA during suppressive antiretroviral therapy (ART).
Shane D. Falcinelli, Shane D. Falcinelli, Cristina Ceriani, Cristina Ceriani, David M. Margolis, David M. Margolis, David M. Margolis, Nancie M. Archin, Nancie M. Archin   +8 more
doaj   +3 more sources

Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence

Viruses, 2020
While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Laurens Lambrechts, Basiel Cole, Sofie Rutsaert, Wim Trypsteen, Linos Vandekerckhove   +4 more
doaj   +3 more sources