Results 21 to 30 of about 35,436 (198)

Analysis of the effect of HDAC inhibitors on the formation of the HIV reservoir [PDF]

mBio
The HIV reservoir is more dynamic than previously thought with around 70% of the latent reservoir originating from viruses circulating within 1 year of the initiation of antiretroviral therapy (ART).
Lijun Ling, Manse Kim, Andrew Soper, Martina Kovarova, Rae Ann Spagnuolo, Nurjahan Begum, Jennifer Kirchherr, Nancie Archin, Diana Battaglia, Dave Cleveland, Angela Wahl, David M. Margolis, Edward P. Browne, J. Victor Garcia   +13 more
doaj   +2 more sources

Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size [PDF]

Scientific Reports
The elimination of the latent viral reservoir remains the main barrier in the quest for a cure for people with HIV (PWH). The administration of latency reversal agents (LRA) at antiretroviral treatment (ART) initiation could improve the effectiveness of ...
Erick De La Torre Tarazona, Elisa Moraga, Raúl Vaquer, Sonsoles Sánchez-Palomino, Elisa de Lazzari, Laura Luna, Sònia Vicens-Artés, Lucio Jesús García Fraile, Joaquim Peraire, Mercedes Garcia-Gasalla, Luz Balsalobre, Sergio Guillén Martínez, Luis Fernando López Cortés, Inma Jarrín, Sergio Serrano-Villar, José Alcamí, Santiago Moreno, CoRIS Cohort   +17 more
doaj   +2 more sources

Dynamics of HIV DNA reservoir seeding in a cohort of superinfected Kenyan women. [PDF]

PLoS Pathogens, 2020
A reservoir of HIV-infected cells that persists despite suppressive antiretroviral therapy (ART) is the source of viral rebound upon ART cessation and the major barrier to a cure.
Mark D Pankau, Daniel B Reeves, Elias Harkins, Keshet Ronen, Walter Jaoko, Kishor Mandaliya, Susan M Graham, R Scott McClelland, Frederick A Matsen Iv, Joshua T Schiffer, Julie Overbaugh, Dara A Lehman   +11 more
doaj   +1 more source

Neutralizing the HIV Reservoir [PDF]

Cell, 2014
Halper-Stromberg et al. use a humanized mouse model to demonstrate that broadly neutralizing antibodies, when administered with a combination of HIV latency activators, can reduce persistent HIV reservoirs, as measured by plasma virus rebound. Their results support the use of broadly neutralizing antibodies in HIV-reservoir-purging strategies.
Marsden, Matthew D, Zack, Jerome A
openaire   +4 more sources

The HIV-1 latent reservoir is largely sensitive to circulating T cells

eLife, 2020
HIV-1-specific CD8+ T cells are an important component of HIV-1 curative strategies. Viral variants in the HIV-1 reservoir may limit the capacity of T cells to detect and clear virus-infected cells.
Joanna A Warren, Shuntai Zhou, Yinyan Xu, Matthew J Moeser, Daniel R MacMillan, Olivia Council, Jennifer Kirchherr, Julia M Sung, Nadia R Roan, Adaora A Adimora, Sarah Joseph, JoAnn D Kuruc, Cynthia L Gay, David M Margolis, Nancie Archin, Zabrina L Brumme, Ronald Swanstrom, Nilu Goonetilleke   +17 more
doaj   +1 more source

Blood Center Testing Allows the Detection and Rapid Treatment of Acute and Recent HIV Infection

Viruses, 2022
Blood donations in South Africa are tested for HIV RNA using individual donation NAT (ID-NAT), allowing detection and rapid antiretroviral therapy (ART) of acute HIV infections.
Karin van den Berg, Marion Vermeulen, Sonia Bakkour, Mars Stone, Genevieve Jacobs, Cynthia Nyoni, Coreen Barker, Christopher McClure, Darryl Creel, Eduard Grebe, Nareg Roubinian, Ute Jentsch, Brian Custer, Michael P. Busch, Edward L. Murphy, on behalf of the Recipient Epidemiology and Donor Evaluation Study (REDS)-III South Africa International Program   +15 more
doaj   +1 more source

Tissue reservoirs of HIV [PDF]

Current Opinion in HIV and AIDS, 2016
Tissue reservoirs of HIV may promote the persistent immunopathology responsible for non-AIDS morbidity and data support multifocal reactivation from tissues as the source of viral rebound during antiretroviral therapy (ART) interruption. The heterogeneity of tissue reservoirs and incomplete knowledge about their composition are obstacles to an HIV cure.
Wong, Joseph K, Yukl, Steven A
openaire   +4 more sources

CD32+CD4+ T Cells Are Highly Enriched for HIV DNA and Can Support Transcriptional Latency

Cell Reports, 2020
Summary: The HIV latent reservoir forms the major hurdle to an HIV cure. The discovery of CD32 as marker of this reservoir has aroused much interest, but subsequent reports have challenged this finding. Here, we observe a positive correlation between the
Gilles Darcis, Neeltje A. Kootstra, Berend Hooibrink, Thijs van Montfort, Irma Maurer, Kevin Groen, Suzanne Jurriaans, Margreet Bakker, Carine van Lint, Ben Berkhout, Alexander O. Pasternak   +10 more
doaj   +1 more source

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

mBio, 2022
Human immunodeficiency virus type 1 (HIV-1) can integrate viral DNA into host cell chromosomes to establish a long-term stable latent reservoir, which is a major obstacle to cure HIV-1 infection. The characteristics of the HIV-1 latent reservoir have not
Wanying Zhang, Mo Zhou, Cancan Chen, Shiyu Wu, Lilin Wang, Baijin Xia, Jun Liu, Xiancai Ma, Ting Pan, Hui Zhang, Linghua Li, Bingfeng Liu   +11 more
doaj   +1 more source

CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir

mBio, 2022
HIV infects long-lived CD4 memory T cells, establishing a latent viral reservoir that necessitates lifelong antiretroviral therapy (ART). How this reservoir is formed so quickly after infection remains unclear.
Thomas A. Packard, Roland Schwarzer, Eytan Herzig, Deepashri Rao, Xiaoyu Luo, Johanne H. Egedal, Feng Hsiao, Marek Widera, Judd F. Hultquist, Zachary W. Grimmett, Ronald J. Messer, Nevan J. Krogan, Steven G. Deeks, Nadia R. Roan, Ulf Dittmer, Kim J. Hasenkrug, Warner C. Greene   +16 more
doaj   +1 more source