Results 21 to 30 of about 36,601 (210)

Tissue reservoirs of HIV [PDF]

Current Opinion in HIV and AIDS, 2016
Tissue reservoirs of HIV may promote the persistent immunopathology responsible for non-AIDS morbidity and data support multifocal reactivation from tissues as the source of viral rebound during antiretroviral therapy (ART) interruption. The heterogeneity of tissue reservoirs and incomplete knowledge about their composition are obstacles to an HIV cure.
Wong, Joseph K, Yukl, Steven A
openaire   +4 more sources

Blood Center Testing Allows the Detection and Rapid Treatment of Acute and Recent HIV Infection

Viruses, 2022
Blood donations in South Africa are tested for HIV RNA using individual donation NAT (ID-NAT), allowing detection and rapid antiretroviral therapy (ART) of acute HIV infections.
Karin van den Berg, Marion Vermeulen, Sonia Bakkour, Mars Stone, Genevieve Jacobs, Cynthia Nyoni, Coreen Barker, Christopher McClure, Darryl Creel, Eduard Grebe, Nareg Roubinian, Ute Jentsch, Brian Custer, Michael P. Busch, Edward L. Murphy, on behalf of the Recipient Epidemiology and Donor Evaluation Study (REDS)-III South Africa International Program   +15 more
doaj   +1 more source

A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size.

PLoS Pathogens, 2023
The major barrier to an HIV cure is the HIV reservoir: latently-infected cells that persist despite effective antiretroviral therapy (ART). There have been few cohort-based studies evaluating host genomic or transcriptomic predictors of the HIV reservoir.
Ashok K Dwivedi, Germán G Gornalusse, David A Siegel, Alton Barbehenn, Cassandra Thanh, Rebecca Hoh, Kristen S Hobbs, Tony Pan, Erica A Gibson, Jeffrey Martin, Frederick Hecht, Christopher Pilcher, Jeffrey Milush, Michael P Busch, Mars Stone, Meei-Li Huang, Julieta Reppetti, Phuong M Vo, Claire N Levy, Pavitra Roychoudhury, Keith R Jerome, Florian Hladik, Timothy J Henrich, Steven G Deeks, Sulggi A Lee   +24 more
doaj   +1 more source

CD32+CD4+ T Cells Are Highly Enriched for HIV DNA and Can Support Transcriptional Latency

Cell Reports, 2020
Summary: The HIV latent reservoir forms the major hurdle to an HIV cure. The discovery of CD32 as marker of this reservoir has aroused much interest, but subsequent reports have challenged this finding. Here, we observe a positive correlation between the
Gilles Darcis, Neeltje A. Kootstra, Berend Hooibrink, Thijs van Montfort, Irma Maurer, Kevin Groen, Suzanne Jurriaans, Margreet Bakker, Carine van Lint, Ben Berkhout, Alexander O. Pasternak   +10 more
doaj   +1 more source

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

mBio, 2022
Human immunodeficiency virus type 1 (HIV-1) can integrate viral DNA into host cell chromosomes to establish a long-term stable latent reservoir, which is a major obstacle to cure HIV-1 infection. The characteristics of the HIV-1 latent reservoir have not
Wanying Zhang, Mo Zhou, Cancan Chen, Shiyu Wu, Lilin Wang, Baijin Xia, Jun Liu, Xiancai Ma, Ting Pan, Hui Zhang, Linghua Li, Bingfeng Liu   +11 more
doaj   +1 more source

CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir

mBio, 2022
HIV infects long-lived CD4 memory T cells, establishing a latent viral reservoir that necessitates lifelong antiretroviral therapy (ART). How this reservoir is formed so quickly after infection remains unclear.
Thomas A. Packard, Roland Schwarzer, Eytan Herzig, Deepashri Rao, Xiaoyu Luo, Johanne H. Egedal, Feng Hsiao, Marek Widera, Judd F. Hultquist, Zachary W. Grimmett, Ronald J. Messer, Nevan J. Krogan, Steven G. Deeks, Nadia R. Roan, Ulf Dittmer, Kim J. Hasenkrug, Warner C. Greene   +16 more
doaj   +1 more source

Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays

Viruses, 2022
Significant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment (ART)-free remission and cure for persons living with HIV-1 are being made with the advent of broadly neutralizing antibodies and very early ART in perinatal ...
Priya Khetan, Yufeng Liu, Adit Dhummakupt, Deborah Persaud   +3 more
doaj   +1 more source

The HIV reservoir landscape in elite controllers. [PDF]

Curr Opin HIV AIDS
Purpose of review In this review, we intend to define the main characteristics of the elite controller reservoir, exploring into its heterogeneity, which goes hand in hand with the different progression phenotypes within elite controllers. Recent findings
Moral-Turón C, Antequera-Martínez M, Ruiz-Mateos E.   +2 more
europepmc   +3 more sources

Engineering CAR T Cells to Target the HIV Reservoir

Frontiers in Cellular and Infection Microbiology, 2020
The HIV reservoir remains to be a difficult barrier to overcome in order to achieve a therapeutic cure for HIV. Several strategies have been developed to purge the reservoir, including the “kick and kill” approach, which is based on the notion that ...
Wenli Mu, Mayra A. Carrillo, Scott G. Kitchen   +2 more
doaj   +1 more source

Predicting Post-treatment HIV Remission: Does Size of the Viral Reservoir Matter?

Frontiers in Microbiology, 2021
Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) replication and improves immune function. However, due to the persistence of long-lived HIV reservoirs, therapy interruption almost inevitably leads to a fast viral ...
Alexander O. Pasternak, Christina K. Psomas, Ben Berkhout   +2 more
doaj   +1 more source