Results 21 to 30 of about 35,308 (213)

Unintegrated HIV-1 provides an inducible and functional reservoir in untreated and highly active antiretroviral therapy-treated patients

Retrovirology, 2007
Background The presence of HIV-1 preintegration reservoir was assessed in an in vitro experimental model of latent HIV-1 infection, and in patients treated or not with highly active antiretroviral therapy (HAART).
Baillat Vincent, Mettling Clement, Tuaillon Edouard, Al Tabaa Yassine, Petitjean Gaël, Reynes Jacques, Segondy Michel, Vendrell Jean   +7 more
doaj   +1 more source

Barriers for HIV Cure: The Latent Reservoir [PDF]

AIDS Research and Human Retroviruses, 2018
Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in search of vaccines and treatments to eradicate this devastating infectious disease. Progress has been made in understanding the molecular pathogenesis of this infection, which has been crucial for the development of the current therapy regimens. However,
Castro-Gonzalez, Sergio, Colomer Lluch, Marta, Serra Moreno, Ruth   +2 more
openaire   +4 more sources

HIV Reservoir Characterization Symposium

Journal of Virus Eradication, 2017
The HIV Cure Research Center (HCRC) in Ghent organised the first HIV Reservoir Characterization Symposium, and brought together virologists, molecular biologists, immunologists and clinicians to discuss the most recent developments in HIV reservoir ...
Eva Malatinkova, Ward De Spiegelaere, Linos Vandekerckhove, Magdalena Sips   +3 more
doaj   +1 more source

Substantial uneven proliferation of CD4+ T cells during recovery from acute HIV infection is sufficient to explain the observed expanded clones in the HIV reservoir

Journal of Virus Eradication, 2022
The HIV reservoir is a population of 1–10 million anatomically dispersed, latently infected memory CD4+ T cells in which HIV DNA is quiescently integrated into human chromosomal DNA.
Florencia A. Tettamanti Boshier, Daniel B. Reeves, Elizabeth R. Duke, David A. Swan, Martin Prlic, E. Fabian Cardozo-Ojeda, Joshua T. Schiffer   +6 more
doaj   +1 more source

Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy. [PDF]

PLoS ONE, 2016
A major challenge to HIV eradication strategies is the lack of an accurate measurement of the total burden of replication-competent HIV (the "reservoir").
Sulggi A Lee, Peter Bacchetti, Nicolas Chomont, Remi Fromentin, Sharon R Lewin, Una O'Doherty, Sarah Palmer, Douglas D Richman, Janet D Siliciano, Steven A Yukl, Steven G Deeks, Peter D Burbelo   +11 more
doaj   +1 more source

Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA

Frontiers in Microbiology, 2021
The presence of a stable HIV-1 reservoir persisting over time despite effective antiretroviral suppression therapy precludes a cure for HIV-1. Characterizing and quantifying this residual reservoir is considered an essential prerequisite to develop and ...
Cynthia Lungu, Riddhima Banga, Rob A. Gruters, Francesco A. Procopio   +3 more
doaj   +1 more source

Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review

Frontiers in Immunology, 2021
Despite the benefits achieved by the widespread availability of modern antiretroviral therapy (ART), HIV RNA integration into the host cell genome is responsible for the creation of latent HIV reservoirs, and represents a significant impediment to ...
Silvere D. Zaongo, Feng Sun, Yaokai Chen
doaj   +1 more source

HIV reservoirs and latency models

Virology, 2011
The main impediment to a cure for HIV is the existence of long-lasting treatment resistant viral reservoirs. In this review, we discuss what is currently known about reservoirs, including their formation and maintenance, while focusing on latently infected CD4+ T cells.
Pace, Matthew J., Agosto, Luis, Graf, Erin H., O'Doherty, Una   +3 more
openaire   +2 more sources

Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy

eLife
Understanding the interplay between the HIV reservoir and the host immune system may yield insights into HIV persistence during antiretroviral therapy (ART) and inform strategies for a cure.
Lesia Semenova, Yingfan Wang, Shane Falcinelli, Nancie Archin, Alicia D Cooper-Volkheimer, David M Margolis, Nilu Goonetilleke, David M Murdoch, Cynthia D Rudin, Edward P Browne   +9 more
doaj   +1 more source

Retinoids: novel potential therapeutics in the pursuit of HIV-1 cure

Frontiers in Virology, 2022
Human immunodeficiency virus (HIV) infection remains a global epidemic. While antiretroviral therapy (ART) suppresses viral replication, cessation of ART results in viral rebound necessitating lifelong treatment.
Andrew Purssell, Michaeline McGuinty, Michaeline McGuinty, Branka Vulesevic, Jonathan B. Angel, Jonathan B. Angel   +5 more
doaj   +1 more source