Natalizumab affects T-cell phenotype in multiple sclerosis: implications for JCV reactivation [PDF]
, 2016 The anti-CD49d monoclonal antibody natalizumab is currently an effective therapy against the relapsing-remitting form of multiple sclerosis (RRMS). Natalizumab therapeutic efficacy is limited by the reactivation of the John Cunningham polyomavirus (JCV ...
A Bellizzi +51 more
core +22 more sources
CD39 Expression in Peripheral T Cells is Associated with Clinicopathological Characteristics in Patients with Cervical Cancer [PDF]
Iranian Journal of Immunology, 2023 Background: CD39 is an inhibitory checkpoint exerting rate-limiting effects on the ATP-adenosine pathway. It can be targeted to block adenosine-mediated immunosuppression.Objective: To analyze the relationship between the CD39 expression and ...
Kuo Zhao, Dongmei Han, Lu Tang, Hao Jin
doaj +1 more source
Aerobic training modulates T cell activation in elderly women with knee osteoarthritis [PDF]
Brazilian Journal of Medical and Biological Research, 2016 Osteoarthritis of the knee (kOA) is a disease that mainly affects the elderly and can lead to major physical and functional limitations. However, the specific effects of walking, particularly on the immune system, are unknown. Therefore, this study aimed
W.F. Gomes +7 more
doaj +3 more sources
Frontiers in Immunology, 2021 T-bet, a T-box family member, is a transcription factor essential for the differentiation of naive CD4+ T cells into Th1 cells that are involved in both innate and adaptive immune responses.
Hongfei Tian +8 more
doaj +1 more source
Iranian Journal of Allergy, Asthma and Immunology, 2023 The reactivation of polyomavirus BK (BKPyV) contributes to increased morbidity and mortality rates of transplant patients, especially kidney transplant recipients (KTRs).
Nasrin Noshadi +4 more
doaj +1 more source
Causes of T lymphocyte activation in HIV-infected patients coinfected with hepatitis C virus [PDF]
Терапевтический архив, 2016 Aim. To establish the causes of T lymphocyte activation in human immunodeficiency virus (HIV)-infected patients coinfected with hepatitis C (HCV) who are adherent to their antiretroviral therapy regimen and interferon untreated.
K V Shmagel +4 more
doaj +1 more source
Prognostic value of tumor-infiltrating T-lymphocytes density in the therapeutic response to initial platinum-based chemotherapy in patients with non-small cell lung cancer [PDF]
Vojnosanitetski Pregled, 2023 Background/Aim. The fact that lung carcinomas, like other solid tumors, can be immunogenic may have a substantial prognostic value in non-small cell lung cancer (NSCLC).
Novaković-Lacković Lora +3 more
doaj +1 more source
Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report
Case Reports in Oncology, 2021 Cutaneous T-cell lymphoma (CTCL) describes a group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin. Mycosis fungoides (MF) represents the most common type of CTCL and accounts for ∼60% of all primary
Monira Abdullah Alnasser +4 more
doaj +1 more source
Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19
Journal of Intensive Care, 2021 We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry.
Yumi Mitsuyama +5 more
doaj +1 more source
altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers. [PDF]
, 2018 The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule.
Genebat González, Miguel +3 more
core +1 more source