Acute SARS-CoV-2 pneumonitis with cytotoxic CD8 positive T-lymphocytes: Case report and review of the literature [PDF]
Pathology Research and Practice, 2021 As of October 2020, there are over 40 million confirmed cases, and more than 1 million confirmed deaths of Covid-19 worldwide. The main cause of death in hospitalized patients is a respiratory failure due to acute respiratory distress syndrome. It has been suggested that the very intense immune response induces diffuse alveolar damage that far exceeds ...
Juan CARLOS Felix +2 more
exaly +4 more sources
Effector functions of CD8-positive guinea pig T lymphocytes [PDF]
Cellular Immunology, 2003 The response of guinea pig T lymphocytes to different stimuli was analysed with focus on the functions of CD8-positive T cells, which so far had been poorly defined in this animal model. For identification and purification of guinea pig cytotoxic T lymphocytes, three monoclonal antibodies, directed against the CD8 differentiation antigen were ...
Hubert Schafer, Reinhard Bürger
exaly +5 more sources
High level of EZH2 expression is linked to high density of CD8-positive T-lymphocytes and an aggressive phenotype in renal cell carcinoma. [PDF]
World J Urol, 2021 Abstract Purpose Enhancer of zeste homolog 2 (EZH2), the catalytic part of the Polycomb repressive complex 2 (PRC2), has a prognostic role in renal cell carcinoma (RCC) and was recently shown to modulate the immune response by reducing tumor cell immunogenicity.
Eichenauer T +16 more
europepmc +4 more sources
Intraepithelial CD8-positive T lymphocytes predict survival for patients with serous stage III ovarian carcinomas: relevance of clonal selection of T lymphocytes [PDF]
British Journal of Cancer, 2009 The aim of this study was to investigate the prognostic effect of tumour-infiltrating lymphocytes (TILs) in serous stage III ovarian carcinoma to determine TIL clonality and to correlate this to Her2/neu expression.Formalin-fixed and paraffin-embedded ovarian carcinomas were examined for CD20-, CD3-, CD4- and CD8-positive lymphocytes (n=100), and for ...
Fisch P, Hasenburg A, S Lassmann
exaly +4 more sources
مجله دانشکده پزشکی اصفهان, 2017 Background: CD8-positive T lymphocytes are important part of cell-mediated immunity and play a central role in induction of immune response against tumor progression.
Simin Hemati +3 more
doaj +1 more source
CD39 Expression in Peripheral T Cells is Associated with Clinicopathological Characteristics in Patients with Cervical Cancer [PDF]
Iranian Journal of Immunology, 2023 Background: CD39 is an inhibitory checkpoint exerting rate-limiting effects on the ATP-adenosine pathway. It can be targeted to block adenosine-mediated immunosuppression.Objective: To analyze the relationship between the CD39 expression and ...
Kuo Zhao, Dongmei Han, Lu Tang, Hao Jin
doaj +1 more source
CD8 Positive T Lymphocyte Infiltration of Liver Metastases of Uveal Melanoma: A Case Report [PDF]
Frontiers in Oncology, 2021 A 78-year-old Japanese man was referred for examination of multiple small nodules on his liver detected by magnetic resonance imaging (MRI). These small nodules were hyperintense on T1-weighted MRI, and were in hepatobiliary phase on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI.
Naoki Takahashi +4 more
openaire +3 more sources
Aerobic training modulates T cell activation in elderly women with knee osteoarthritis [PDF]
Brazilian Journal of Medical and Biological Research, 2016 Osteoarthritis of the knee (kOA) is a disease that mainly affects the elderly and can lead to major physical and functional limitations. However, the specific effects of walking, particularly on the immune system, are unknown. Therefore, this study aimed
W.F. Gomes +7 more
doaj +3 more sources
CD39 molecule: a negative regulator expressed on T cells in patients with lung adenocarcinoma
Archives of Medical Science, 2023 Introduction The function of cytotoxic cells may be impacted by CD39 expression on CD8-positive T lymphocytes, leading to an imbalance in tumor immunity.
Lu Tang, Hao Jin
doaj +1 more source
Cytotoxic CD8-positive T-lymphocyte infiltration in the lungs as a histological pattern of SARS-CoV-2 pneumonitis [PDF]
Pathology, 2022 Despite millions of PCR confirmed cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, the long-term pathophysiological changes induced by this infection in the lungs and their relationship with possible immune triggers remain incompletely understood. Acute respiratory distress syndrome and subsequent respiratory failure are
Puzyrenko, Andrii +5 more
openaire +2 more sources