Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells. [PDF]
PLoS ONE, 2016 As part of an international effort to develop vaccines for Theileria lestoquardi, we undertook a limited screen to test T. lestoquardi orthologues of antigens recognised by CD8+ T lymphocyte responses against T. annulata and T. parva in cattle.
Shan Goh +10 more
doaj +7 more sources
Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library. [PDF]
PLoS ONE, 2013 Identification of CD8(+) T cell antigens/epitopes expressed by human pathogens with large genomes is especially challenging, yet necessary for vaccine development.
David M Lewinsohn +8 more
doaj +1 more source
Viral sequestration of antigen subverts cross presentation to CD8(+) T cells. [PDF]
PLoS Pathogens, 2009 Virus-specific CD8(+) T cells (T(CD8+)) are initially triggered by peptide-MHC Class I complexes on the surface of professional antigen presenting cells (pAPC). Peptide-MHC complexes are produced by two spatially distinct pathways during virus infection.
Eric F Tewalt +7 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Cysticercus cellulosae (C. cellulosae) excretes and secretes antigens during the parasitic process to regulate the host immune response; however, resulting immune response and cytokine production in the host during infection still remains unclear.
Xianmin Fan +10 more
doaj +1 more source
Liposome-coupled antigens are internalized by antigen-presenting cells via pinocytosis and cross-presented to CD8 T cells. [PDF]
PLoS ONE, 2010 We have previously demonstrated that antigens chemically coupled to the surface of liposomes consisting of unsaturated fatty acids were cross-presented by antigen-presenting cells (APCs) to CD8+ T cells, and that this process resulted in the induction of
Yuriko Tanaka +4 more
doaj +1 more source
Dendritic cells crosspresent antigens from live B16 cells more efficiently than from apoptotic cells and protect from melanoma in a therapeutic model. [PDF]
PLoS ONE, 2011 Dendritic cells (DC) are able to elicit anti-tumoral CD8(+) T cell responses by cross-presenting exogenous antigens in association with major histocompatibility complex (MHC) class I molecules.
Diana Matheoud +8 more
doaj +1 more source
Efficient Isolation of Influenza Specific CTLs
Bio-Protocol, 2016 Human antigen-specific CD8+ T-cell clones are valuable tools for dissecting CD8+ T-cell responses against antigens derived from infectious agents, cancer and self antigens.
Prerak Trivedi, Stuart Mannering
doaj +1 more source
QuilA-adjuvanted T. gondii lysate antigens trigger robust antibody and IFNγ+ T cell responses in pigs leading to reduction in parasite DNA in tissues upon challenge infection [PDF]
, 2019 Toxoplasma gondii is an intracellular parasite of all mammals and birds, responsible for toxoplasmosis. In healthy individuals T. gondii infections mostly remain asymptomatic, however this parasite causes severe morbidity and mortality in ...
Cox, Eric +6 more
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Tissue signatures influence the activation of intrahepatic CD8+ T cells against malaria sporozoites
Frontiers in Microbiology, 2014 Plasmodium sporozoites and liver stages express antigens that are targeted to the MHC-Class I antigen-processing pathway. After the introduction of Plasmodium sporozoites by Anopheles mosquitoes, bone marrow-derived dendritic cells in skin-draining lymph
Alexandre eMorrot +1 more
doaj +1 more source
Hyperpigmentation as a peculiar presentation of mycosis fungoides [PDF]
Anais Brasileiros de Dermatologia, 2017 Hyperpigmented mycosis fungoides is an extremely rare subtype of mycosis fungoides. It presents as multiple pigmented macules and patches without poikilodermatous changes and characterized by a CD8+ phenotype on immunohistochemistry.
Ying-Yi Lu +3 more
doaj +1 more source