Results 21 to 30 of about 175,253 (265)
Differences in antigen recognition and cytolytic activity of CD8 + and CD8 − T cells that express the same antigen-specific receptor [PDF]
Proceedings of the National Academy of Sciences, 2001 CD8 + and CD8 − T cell lines expressing the same antigen-specific receptor [the 2C T cell receptor (TCR)] were compared for ability to bind soluble peptide-MHC and to lyse target cells.
B K, Cho +7 more
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CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment
Cells, 2021 The scanning of surrounding tissues by T lymphocytes to detect cognate antigens requires high speed, sensitivity and specificity. T-cell receptor (TCR) co-receptors such as CD8 increase detection performance, but the exact mechanism remains incompletely ...
Philippe Robert +3 more
doaj +1 more source
Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment
Frontiers in Immunology, 2018 Dendritic cells (DCs) play a central role in the regulation of the balance between CD8 T cell immunity vs. tolerance to tumor antigens. Cross-priming, a process which DCs activate CD8 T cells by cross-presenting exogenous antigens, plays a critical role ...
Chunmei Fu, Aimin Jiang
doaj +1 more source
Frontiers in Immunology, 2020 CD8+ T cells, the most abundant T cell subset in the decidua, play a critical role in the maintenance of pregnancy. The majority of decidual CD8+ T cells have an effector memory phenotype, while those in the peripheral blood display a naive phenotype. An
Keiko Morita +9 more
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Non-antigen specific CD8+ T suppressor lymphocytes
Clinical and Experimental Medicine, 2004 The homeostasis of peripheral immune system function is maintained by the activity of regulatory lymphocytes. Among these cells, a subset of CD8+CD28- T suppressor lymphocytes has recently been characterized for the capacity to mediate their effects without antigen restriction.
FILACI, GILBERTO +6 more
openaire +3 more sources
JCI Insight, 2023 CD8+ T cells can recognize tumor antigens displayed by HLA class I molecules and eliminate tumor cells. Despite their low tumor mutation burden, immune checkpoint blockade (ICB) is often beneficial in patients with renal cell carcinoma (RCC). Here, using
Shin Kobayashi +8 more
doaj +1 more source
Antigen delivery to dendritic cells shapes human CD4+ and CD8+ T cell memory responses to Staphylococcus aureus. [PDF]
PLoS Pathogens, 2017 Intracellular persistence of Staphylococcus aureus favors bacterial spread and chronic infections. Here, we provide evidence for the existence of human CD4+ and CD8+ T cell memory against staphylococcal antigens.
Julia Uebele +8 more
doaj +1 more source
Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2015 To determine the antigenic determinants and specific molecular requirements for the generation of autoregulatory neuroantigen-specific CD8(+) T cells in models of multiple sclerosis (MS).We have previously shown that MOG35-55-specific CD8(+) T cells suppress experimental autoimmune encephalomyelitis (EAE) in the C57BL/6 model.
Ortega, Sterling B. +4 more
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Antigen and Memory CD8 T Cells: Were They Both Right? [PDF]
Allergy, Asthma, and Clinical Immunology, 2007 Abstract Picture yourself as a researcher in immunology. To begin your project, you ask a question: Do CD8 T cells require antigen to maintain a memory response? This question is of prime importance to numerous medical fields. In chronologic order, you digest the literature, but unfortunately, you hit a major stumbling block in the 1990s. The
Epelman Slava, Mody Christopher H
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Frontiers in Immunology, 2021 Increasing evidence suggests that post-translational peptide splicing can play a role in the immune response under pathological conditions. This seems to be particularly relevant in Type 1 Diabetes (T1D) since post-translationally spliced epitopes ...
Michele Mishto +5 more
doaj +1 more source