Results 21 to 30 of about 459,921 (305)

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose [PDF]

Proceedings of the National Academy of Sciences, 1999
There are two major mechanisms reported to prevent the autoreactivity of islet-specific CD8 + T cells: ignorance and tolerance. When ignorance is operative, naïve autoreactive CD8 + T cells ignore islet antigens and recirculate without causing damage ...
C, Kurts, R M, Sutherland, G, Davey, M, Li, A M, Lew, E, Blanas, F R, Carbone, J F, Miller, W R, Heath   +8 more
openaire   +2 more sources

Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity [PDF]

, 2011
<p><b>Background:</b> Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer).
Taracha, E. L. N., Mwangi Duncan M., Graham Simon P., Paul R. Spooner, Graham, S. P., Saya, RM, Toye, PG, Njahira, Moses N., Pelle, R., Richard P Bishop, Musoke, AJ, Silva, J., Rosemary M. Saya, Philip G Toye, Toye Philip G., Njahira, M.N., Saya, R. A., Evans L. N. Taracha, Musoke, A. J., Pelle Roger, Odongo, DO, Silva Joana C., Roger Pelle, Musoke Anthony J., Morrison, Ivan, Weir, W., Silva, J.C., Anthony J. Musoke, Joana C Silva, Graham, SP, Bishop, Richard P., Odongo, David O., Simon P Graham, Paul R Spooner, Taracha, EL, Morrison W. Ivan, Pelle, R, Bishop, R.P., Toye, P. G., Moses N Njahira, Saya Rosemary M., Duncan M. Mwangi, Spooner, P.R., Osaso Julius, Mwangi, D.M., W. Ivan Morrison, Toye, P.G., Silva, J. C., David O. Odongo, Osaso, J, Morrison, WI, Simon P. Graham, Moses N. Njahira, Mwangi, D. M., Evans L N Taracha, Taracha Evans L. N., Mwangi, DM, Odongo, D.O., Taracha, E.L.N., Bishop, RP, Morrison, W.I., Bishop, R. P., Njahira, M. N., Saya, R.M., Spooner, PR, Musoke, A.J., Saya, Rosemary M., Spooner, P. R., Richard P. Bishop, Pelle, Roger, Mwangi, David Miano, Spooner Paul R., Rosemary M Saya, Odongo David O., Njahira, MN, Joana C. Silva, Odongo, D. O., Duncan M Mwangi, Julius Osaso, W Ivan Morrison, Toye, Philip G., Njahira Moses N., Philip G. Toye, Morrison, W. Ivan, David O Odongo, Weir William, Bishop Richard P., Silva, JC, Osaso, J., Anthony J Musoke, Graham, S.P., William Weir, Weir, W   +92 more
core   +1 more source

Profiling the Targets of Protective CD8+ T Cell Responses to Infection

Molecular Therapy: Methods & Clinical Development, 2017
T cells are critical effectors of host immunity that target intracellular pathogens, such as the causative agents of HIV, tuberculosis, and malaria.
Joseph T. Bruder, Ping Chen, Greg Ekberg, Emily C. Smith, Christopher A. Lazarski, Bennett A. Myers, Jessica Bolton, Martha Sedegah, Eileen Villasante, Thomas L. Richie, C. Richter King, Joao C. Aguiar, Denise L. Doolan, Douglas E. Brough   +13 more
doaj   +1 more source

In-depth analysis of human virus-specific CD8+ T cells delineates unique phenotypic signatures for T cell specificity prediction

Cell Reports, 2023
Summary: Following viral infection, the human immune system generates CD8+ T cell responses to virus antigens that differ in specificity, abundance, and phenotype.
Florian Schmidt, Hannah F. Fields, Yovita Purwanti, Ana Milojkovic, Syazwani Salim, Kan Xing Wu, Yannick Simoni, Antonella Vitiello, Daniel T. MacLeod, Alessandra Nardin, Evan W. Newell, Katja Fink, Andreas Wilm, Michael Fehlings   +13 more
doaj   +1 more source

Immunity to Intracellular Salmonella Depends on Surface-associated Antigens [PDF]

, 2012
Invasive Salmonella infection is an important health problem that is worsening because of rising antimicrobial resistance and changing Salmonella serovar spectrum.
Rizos Konstantin, Beatrice Claudi (126116), Dirk Bumann (126124), Dirk Bumann, Somedutta Barat (126107), Barat, Somedutta, Rizos, K., Bumann, D., Schemmer, Anne K, Claudi Beatrice, Neil Burton (126123), Anne K Schemmer, Barat Somedutta, Dennis Kirchhoff (126121), Somedutta Barat, Alexander Schmidt (68515), Kirchhoff, D., Alain Mazé, Willer, Yvonne, Anne K. Schemmer (126119), Kirchhoff Dennis, Rizos, Konstantin, Dennis Kirchhoff, Bumann, Dirk, Burton Neil, Schemmer, A., Claudi, B., Mazé, Alain, Schmidt Alexander, Schemmer Anne K., Yvonne Willer (126110), Konstantin Rizos (126113), Willer Yvonne, Yvonne Willer, Willer, Y., Burton, Neil, Bumann Dirk, Alexander Schmidt, Mazé Alain, Beatrice Claudi, Schmidt, A., Alain Mazé (126117), Mazé, A., Claudi, Beatrice, Kirchhoff, Dennis, Barat, S., Konstantin Rizos, Burton, N., Schemmer, Anne K., Schmidt, Alexander, Neil Burton   +50 more
core   +2 more sources

Differences in antigen recognition and cytolytic activity of CD8 ⁺ and CD8 ⁻ T cells that express the same antigen-specific receptor [PDF]

Proceedings of the National Academy of Sciences, 2001
CD8 + and CD8 − T cell lines expressing the same antigen-specific receptor [the 2C T cell receptor (TCR)] were compared for ability to bind soluble peptide-MHC and to lyse target cells.
B K, Cho, K C, Lian, P, Lee, A, Brunmark, C, McKinley, J, Chen, D M, Kranz, H N, Eisen   +7 more
openaire   +2 more sources

CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment

Cells, 2021
The scanning of surrounding tissues by T lymphocytes to detect cognate antigens requires high speed, sensitivity and specificity. T-cell receptor (TCR) co-receptors such as CD8 increase detection performance, but the exact mechanism remains incompletely ...
Philippe Robert, Laurent Limozin, P. Anton van der Merwe, Pierre Bongrand   +3 more
doaj   +1 more source

The frequency of Chlamydia trachomatis major outer membrane protein-specific CD8+ T lymphocytes in active trachoma is associated with current ocular infection. [PDF]

, 2006
Chlamydia-specific cytotoxic T lymphocytes are able to control model infections but may be implicated in disease pathogenesis. HLA-A2 peptide tetramers to Chlamydia trachomatis major outer membrane protein 258-266 (MOMP258-266) and MOMP260-268 were used ...
Nkoyo Faal, Frederick Pemberton-Pigott, Hazel M. Dockrell, David C. W. Mabey, Martin J. Holland, Bailey, Robin L, Holland, Martin J, Pemberton-Pigott, Frederick, Joof, Hassan, Laye, Mass, Hassan Joof, Mass Laye, Sarr, Isatou, Ewen Cameron, Faal, Nkoyo, Isatou Sarr, Cameron, Ewen, Dockrell, Hazel M, Mabey, David CW, Robin L. Bailey   +19 more
core   +1 more source

Non-antigen specific CD8+ T suppressor lymphocytes

Clinical and Experimental Medicine, 2004
The homeostasis of peripheral immune system function is maintained by the activity of regulatory lymphocytes. Among these cells, a subset of CD8+CD28- T suppressor lymphocytes has recently been characterized for the capacity to mediate their effects without antigen restriction.
FILACI, GILBERTO, FRAVEGA M, FENOGLIO, DANIELA, RIZZI M, NEGRINI, SIMONE, VIGGIANI R, INDIVERI, FRANCESCO   +6 more
openaire   +3 more sources

Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment

Frontiers in Immunology, 2018
Dendritic cells (DCs) play a central role in the regulation of the balance between CD8 T cell immunity vs. tolerance to tumor antigens. Cross-priming, a process which DCs activate CD8 T cells by cross-presenting exogenous antigens, plays a critical role ...
Chunmei Fu, Aimin Jiang
doaj   +1 more source