Results 21 to 30 of about 257,746 (309)

Cd8 T‐cell recognition of human 5T4 oncofetal antigen [PDF]

International Journal of Cancer, 2006
AbstractThe 5T4 oncofetal antigen is expressed by a wide variety of human carcinomas, including colorectal, ovarian and gastric carcinomas. The restricted expression of 5T4 on tumor tissues as well as its implication in tumor progression and bad prognosis makes 5T4 a promising new candidate for immunotherapy.
Lucy J C, Smyth, Eyad, Elkord, Taher E I, Taher, Hui-Rong, Jiang, Deborah J, Burt, Alison, Clayton, Peter A, van Veelen, Arnoud, de Ru, Ferry, Ossendorp, Cornelis J M, Melief, Jan W, Drijfhout, Said, Dermime, Robert E, Hawkins, Peter L, Stern   +13 more
openaire   +2 more sources

Modulation of antigen-specific T-cells as immune therapy for chronic infectious diseases and cancer [PDF]

, 2014
Copyright: © 2014 Li, Symonds, Miao, Sanderson and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Abraham, Ahmadzadeh, Akbar, Anderson, Baine, Barber, Baur, Belkaid, Bensinger, Bergmann, Berzofsky, Blackburn, Brooks, Brooks, Brooks, Colonna, Das, Day, Duraiswamy, Ejrnaes, Frebel, Geijtenbeek, Guidotti, Ha, Jerome, Jung, Kasprowicz, Kaufmann, Kim, Klein, Kroemer, Kroy, Larsson, Liu, Lu, Maizels, Malek, Matsuzaki, Mier, Mumprecht, Nandedkar, Nurieva, Nurieva, Ramsay, Schietinger, Schwartz, Sofra, Soldaini, Steinman, Trautmann, Vezys, Waggoner, Wedemeyer, Wilson, Yi, Zhou   +55 more
core   +2 more sources

The combination of CDX2 expression status and tumor-infiltrating lymphocyte density as a prognostic factor in adjuvant FOLFOX-treated patients with stage III colorectal cancers [PDF]

Journal of Pathology and Translational Medicine
Background Colorectal carcinomas (CRCs) with caudal-type homeobox 2 (CDX2) loss are recognized to pursue an aggressive behavior but tend to be accompanied by a high density of tumor-infiltrating lymphocytes (TILs).
Ji-Ae Lee, Hye Eun Park, Hye-Yeong Jin, Lingyan Jin, Seung Yeon Yoo, Nam-Yun Cho, Jeong Mo Bae, Jung Ho Kim, Gyeong Hoon Kang   +8 more
doaj   +1 more source

Profiling the Targets of Protective CD8+ T Cell Responses to Infection

Molecular Therapy: Methods & Clinical Development, 2017
T cells are critical effectors of host immunity that target intracellular pathogens, such as the causative agents of HIV, tuberculosis, and malaria.
Joseph T. Bruder, Ping Chen, Greg Ekberg, Emily C. Smith, Christopher A. Lazarski, Bennett A. Myers, Jessica Bolton, Martha Sedegah, Eileen Villasante, Thomas L. Richie, C. Richter King, Joao C. Aguiar, Denise L. Doolan, Douglas E. Brough   +13 more
doaj   +1 more source

In-depth analysis of human virus-specific CD8+ T cells delineates unique phenotypic signatures for T cell specificity prediction

Cell Reports, 2023
Summary: Following viral infection, the human immune system generates CD8+ T cell responses to virus antigens that differ in specificity, abundance, and phenotype.
Florian Schmidt, Hannah F. Fields, Yovita Purwanti, Ana Milojkovic, Syazwani Salim, Kan Xing Wu, Yannick Simoni, Antonella Vitiello, Daniel T. MacLeod, Alessandra Nardin, Evan W. Newell, Katja Fink, Andreas Wilm, Michael Fehlings   +13 more
doaj   +1 more source

CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment

Cells, 2021
The scanning of surrounding tissues by T lymphocytes to detect cognate antigens requires high speed, sensitivity and specificity. T-cell receptor (TCR) co-receptors such as CD8 increase detection performance, but the exact mechanism remains incompletely ...
Philippe Robert, Laurent Limozin, P. Anton van der Merwe, Pierre Bongrand   +3 more
doaj   +1 more source

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source

Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment

Frontiers in Immunology, 2018
Dendritic cells (DCs) play a central role in the regulation of the balance between CD8 T cell immunity vs. tolerance to tumor antigens. Cross-priming, a process which DCs activate CD8 T cells by cross-presenting exogenous antigens, plays a critical role ...
Chunmei Fu, Aimin Jiang
doaj   +1 more source

Analysis of TCR Repertoire and PD-1 Expression in Decidual and Peripheral CD8+ T Cells Reveals Distinct Immune Mechanisms in Miscarriage and Preeclampsia

Frontiers in Immunology, 2020
CD8+ T cells, the most abundant T cell subset in the decidua, play a critical role in the maintenance of pregnancy. The majority of decidual CD8+ T cells have an effector memory phenotype, while those in the peripheral blood display a naive phenotype. An
Keiko Morita, Sayaka Tsuda, Eiji Kobayashi, Hiroshi Hamana, Kei Tsuda, Tomoko Shima, Akitoshi Nakashima, Akemi Ushijima, Hiroyuki Kishi, Shigeru Saito   +9 more
doaj   +1 more source

Identification and validation of targets for cancer immunotherapy: from the bench-to-bedside [PDF]

, 2013
Chapter 12 in Novel Gene Therapy ...
Brooks, Suzanne E., Denniss, Frances, Guinn, Barbara-Ann, Khan, Ghazala, Sigurdardottir, Dagmar   +4 more
core   +3 more sources