Results 41 to 50 of about 257,746 (309)

Antigen presenting capacity of murine splenic myeloid cells [PDF]

, 2017
BACKGROUND: The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised although dendritic cell (DC) subsets are
Hey, Ying-Ying, O'Neill, Helen C, Quah, Benjamin   +2 more
core   +2 more sources

Potential Mimicry of Viral and Pancreatic β Cell Antigens Through Non-Spliced and cis-Spliced Zwitter Epitope Candidates in Type 1 Diabetes

Frontiers in Immunology, 2021
Increasing evidence suggests that post-translational peptide splicing can play a role in the immune response under pathological conditions. This seems to be particularly relevant in Type 1 Diabetes (T1D) since post-translationally spliced epitopes ...
Michele Mishto, Michele Mishto, Artem Mansurkhodzhaev, Teresa Rodriguez-Calvo, Teresa Rodriguez-Calvo, Juliane Liepe   +5 more
doaj   +1 more source

Immunogenicity of targeted lentivectors [PDF]

, 2014
To increase the safety and possibly efficacy of HIV-1 derived lentivectors (LVs) as an anti-cancer vaccine, we recently developed the Nanobody (Nb) display technology to target LVs to antigen presenting cells (APCs).
Adotévi, Bennett, Bevan, Bhardwaj, Bhardwaj, Bhardwaj, Blander, Bonehill, Bonehill, Breckpot, Breckpot, Breckpot, Charleston, Chuah, Collins, Collins, Collins, Collins, Cosset, Diebold, Donckier, Eggermont, Enk, Figdor, Gajewski, Garcia, Groettrup, Inaba, Kast, Lahoutte, Lévy, McCullough, Medzhitov, Melief, Mellman, Mortha, Moser, Moser, Munn, Naldini, Neyns, Noguiez-Hellin, Nussenzweig, Palena, Raes, Reis e Sousa, Reiser, Reiser, Richardson, Romani, Roncarolo, Sakuma, Schroyens, Semesyuk, Song, Storm, Thielemans, Thielemans, Thielemans, Thielemans, Torretta, Turk, Van Kooyk, Wang, Wang, Yamaguchi, Yewdell, Yu   +67 more
core   +3 more sources

CD8^– dendritic cells preferentially cross‐present Saccharomyces cerevisiae antigens [PDF]

European Journal of Immunology, 2008
AbstractMouse splenic dendritic cell (DC) subsets possess distinct antigen‐presentation abilities. CD8+ DC are specialized in cross‐presentation of antigens to CD8+ T cells, whereas CD8– DC are more efficient in antigen presentation to CD4+ T cells. In this study, we examined the capacity of CD8+ and CD8– DC subsets to present fungal antigens in MHC ...
Backer, R.A., van Leeuwen, F.E., Kraal, G., den Haan, J.M.M.   +3 more
openaire   +3 more sources

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

Spatial coordination of CD8 and TCR molecules controls antigen recognition by CD8⁺ T‐cells

FEBS Letters, 2005
The interactions between the TCR and peptides bound to class I MHC encoded molecules (pMHC) and a mechanism for CD8 cooperation in this process are reviewed. Observation of two TCR/CD8 populations with different lateral diffusion rate constants as well as two distinct association phases of class I MHC tetramers ((pMHC)4) with T‐cells suggest that the ...
Pecht, Israel, Gakamsky, Dmitry M.
openaire   +2 more sources

Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria [PDF]

, 2015
BACKGROUND Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria.
Bijker, Else M, Cockburn, Ian, Nganou-Makamdop, Krystelle, Sauerwein, Robert W, van Gemert, Geert-Jan, Zavala, Fidel   +5 more
core   +2 more sources

Evidence for conservation in antigen gene sequences combined with extensive polymorphism at VNTR loci [PDF]

, 2020
Theileria parva is a tick‐transmitted apicomplexan protozoan parasite that infects lymphocytes of cattle and African Cape buffalo (Syncerus caffer), causing a frequently fatal disease of cattle in eastern, central and southern Africa.
Ahmed, Jabbar, Bishop, Richard P., Clausen, Peter‐Henning, Kabi, Fredrick, Kasaija, Paul, Lubega, George W., Mwega, Elisa, Nanteza, Anne, Njahira, Moses, Njuguna, Joyce, Obara, Isaiah, Odongo, David, Salih, Diaeldin A., Skilton, Rob A.   +13 more
core   +1 more source

Hepatocellular carcinoma escapes immune surveillance through deceiving thymus into recalling peripheral activated CD8+ T cells

Neoplasia: An International Journal for Oncology Research
The role of thymic epithelial cells (TECs) in eliminating self-reactive T cells through the presentation of self-antigens is well-established. However, it remains unclear whether TECs can eliminate tumor-reactive CD8+ T cells by presenting tumor antigens.
Qiaoting Hu, Xuefeng Wang, Yundan You, Jun Liu, Bin Lan, Fangfang Chen, Hong Wen, Haili Cheng, Weibin Zhuo, Ting Xu, Jingxian Zheng, Yuchuan Jiang, Xiaojie Wang, Jing Lin, Zengqing Guo, Sha Huang, Gang Chen, Yu Chen, Jingfeng Liu   +18 more
doaj   +1 more source

An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes: Is There Relevance for Vaccine Development?

Frontiers in Immunology, 2017
Efficient and safe induction of CD8+ T cell responses is a desired characteristic of vaccines against intracellular pathogens. To achieve this, a new generation of safe vaccines is being developed accommodating single, dominant antigens of pathogens of ...
Anouk C. M. Platteel, Juliane Liepe, Willem van Eden, Michele Mishto, Michele Mishto, Michele Mishto, Alice J. A. M. Sijts   +6 more
doaj   +1 more source