Results 41 to 50 of about 459,921 (305)
Quantitation of antigen-specific CD8+ T-cell responses
Immunology Letters, 1999 Enumeration of antigen-specific CD8+ T-cells has traditionally been largely dependent on the use of techniques that require a period of expansion in vitro. However the recent emergence of methods that can be used directly ex vivo to quantify antigen-specific CD8+ T cells has prompted a re-evaluation of the magnitude of viral-specific cellular immune ...
Ogg, G, Mcmichael, A
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Cutting Edge: Antigen-Independent CD8 T Cell Proliferation [PDF]
The Journal of Immunology, 2001 Abstract Recent analyses of CD8 T cell responses to Listeria monocytogenes infection demonstrate that the duration of in vivo T cell proliferation is not determined by the amount or duration of Ag presentation. However, the extent to which T lymphocytes are capable of proliferating in the absence of Ag is unknown.
P, Wong, E G, Pamer
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Frontiers in Immunology, 2017 Efficient and safe induction of CD8+ T cell responses is a desired characteristic of vaccines against intracellular pathogens. To achieve this, a new generation of safe vaccines is being developed accommodating single, dominant antigens of pathogens of ...
Anouk C. M. Platteel +6 more
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Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. [PDF]
, 2011 During human and murine cytomegalovirus (MCMV) infection an exceptionally large virus-specific CD8 T cell pool is maintained in the periphery lifelong.
Torti, Nicole +15 more
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Activation of CD8 T Cells by Antigen Expressed in the Pituitary Gland [PDF]
The Journal of Immunology, 2002 Abstract Ag expressed exclusively in the anterior pituitary gland and secreted locally by pituitary somatotrophs can gain access to the MHC class I presentation pathway and activate CD8 T cells. Influenza nucleoprotein (NP) was expressed as a transgene under the control of the human growth hormone (GH) locus control region. Activation of
James, de Jersey +4 more
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Neoplasia: An International Journal for Oncology ResearchThe role of thymic epithelial cells (TECs) in eliminating self-reactive T cells through the presentation of self-antigens is well-established. However, it remains unclear whether TECs can eliminate tumor-reactive CD8+ T cells by presenting tumor antigens.
Qiaoting Hu +18 more
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Frontiers in Cellular and Infection Microbiology, 2021 Behind the central nervous system, neurotropic viruses can reach and persist even in the enteric nervous system (ENS), the neuronal network embedded in the gut wall.
Paola Brun +11 more
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Antigen and Memory CD8 T Cells: Were They Both Right? [PDF]
Allergy, Asthma, and Clinical Immunology, 2007 Abstract Picture yourself as a researcher in immunology. To begin your project, you ask a question: Do CD8 T cells require antigen to maintain a memory response? This question is of prime importance to numerous medical fields. In chronologic order, you digest the literature, but unfortunately, you hit a major stumbling block in the 1990s. The
Epelman Slava, Mody Christopher H
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Characterisation of CD8neg and CD8+ human natural killer cell subsets [PDF]
, 2012 NK cells are CD3neg CD56+ lymphocytes that constitute about 10-15% of peripheral blood lymphocytes. They have an innate ability to recognise and kill virus infected cells and tumour cells.
Abdalla, Ibrahim.I.I.
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Frontiers in Immunology, 2023 IntroductionA highly efficacious and durable vaccine against malaria is an essential tool for global malaria eradication. One of the promising strategies to develop such a vaccine is to induce robust CD8+ T cell mediated immunity against malaria liver ...
Laura Padula +20 more
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