Results 61 to 70 of about 500,097 (256)

Immunization-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection

npj Vaccines
Antigens from viruses or immunizations can persist or are archived in lymph node stromal cells such as lymphatic endothelial cells (LEC) and fibroblastic reticular cells (FRC). Here, we find that, during the time frame of antigen archiving, LEC apoptosis
Thu A. Doan, Tadg S. Forward, Johnathon B. Schafer, Erin D. Lucas, Ira Fleming, Aspen Uecker-Martin, Edgardo Ayala, Jenna J. Guthmiller, Jay R. Hesselberth, Thomas E. Morrison, Beth A. Jirón Tamburini   +10 more
doaj   +1 more source

Diffuse Large B-Cell Lymphoma with Aberrant Coexpression of CD5 and CD8 T-Cell Markers

Case Reports in Oncology
Introduction: The expression of T-cell-associated antigens on diffuse large B-cell lymphoma (DLBCL) is uncommon. The coexpression of ≥2 T-cell-associated antigens on DLBCL is even rarer.
Janet Fan, Sarita Thanedar, Vasily Ovechko, Bagi Jana   +3 more
doaj   +1 more source

Preproinsulin Designer Antigens Excluded from Endoplasmic Reticulum Suppressed Diabetes Development in NOD Mice by DNA Vaccination

Molecular Therapy: Methods & Clinical Development, 2019
DNA vaccines against autoimmune type 1 diabetes (T1D) contain a nonpredictable risk to induce autoreactive T cell responses rather than a protective immunity. Little is known if (and how) antigen expression and processing requirements favor the induction
Katja Stifter, Cornelia Schuster, Jana Krieger, Andreas Spyrantis, Bernhard Otto Boehm, Reinhold Schirmbeck   +5 more
doaj   +1 more source

Production of Proinflammatory Cytokines by CD4+ and CD8+ T Cells in Response to Mycobacterial Antigens among Children and Adults with Tuberculosis

Pathogens, 2023
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of pediatric morbidity and mortality. Young children are at high risk of TB following Mtb exposure, and this vulnerability is secondary to insufficient host immunity ...
Erin Morrow, Qijia Liu, Sarah Kiguli, Gwendolyn Swarbrick, Mary Nsereko, Megan D. Null, Meghan Cansler, Harriet Mayanja-Kizza, W. Henry Boom, Phalkun Chheng, Melissa R. Nyendak, David M. Lewinsohn, Deborah A. Lewinsohn, Christina L. Lancioni   +13 more
doaj   +1 more source

Tumor antigen cross-presentation and the dendritic cell: Where it all begins? [PDF]

, 2010
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts ...
McDonnell, A.M., Robinson, B.W.S., Currie, A.J.   +2 more
core  

IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

, 2002
CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days
Morrot, Alexandre, Gen-ichiro Sano, Alexandre Morrot, Maria A. Curotto de Lafaille, Fidel Zavala, Hafalla, Julius CR, Carvalho, Luzia H, Curotto de Lafaille, Maria A, Zavala, Fidel, Luzia H. Carvalho, Julius C.R. Hafalla, Sano, Gen-Ichiro   +11 more
core   +1 more source

The frequency of Chlamydia trachomatis major outer membrane protein-specific CD8+ T lymphocytes in active trachoma is associated with current ocular infection. [PDF]

, 2006
Chlamydia-specific cytotoxic T lymphocytes are able to control model infections but may be implicated in disease pathogenesis. HLA-A2 peptide tetramers to Chlamydia trachomatis major outer membrane protein 258-266 (MOMP258-266) and MOMP260-268 were used ...
Nkoyo Faal, Frederick Pemberton-Pigott, Hazel M. Dockrell, David C. W. Mabey, Martin J. Holland, Bailey, Robin L, Holland, Martin J, Pemberton-Pigott, Frederick, Joof, Hassan, Laye, Mass, Hassan Joof, Mass Laye, Sarr, Isatou, Ewen Cameron, Faal, Nkoyo, Isatou Sarr, Cameron, Ewen, Dockrell, Hazel M, Mabey, David CW, Robin L. Bailey   +19 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Exposure to Abnormal Self Antigens During Non-Malignant Inflammatory Events Provides Immunological Defense Against Tumors [PDF]

, 2013
Cancer immunosurveillance is the body’s sentinel mechanism of recognizing and eliminating malignancy. Specifically, the immune system can mount a response against cancer through the recognition of tumor associated antigens (TAA). While studying two TAAs,
Iheagwara, Uzoma
core