Results 71 to 80 of about 459,921 (305)

Neoantigen-specific T cell help outperforms non-specific help in multi-antigen DNA vaccination against cancer

Molecular Therapy: Oncology
CD4+ T helper antigens are essential components of cancer vaccines, but the relevance of the source of these MHC class II-restricted antigens remains underexplored. To compare the effectiveness of tumor-specific versus tumor-unrelated helper antigens, we
Joanna Fréderique de Graaf, Tamara Pesic, Felicia S. Spitzer, Koen Oosterhuis, Marcel G.M. Camps, Iris Zoutendijk, Bram Teunisse, Wahwah Zhu, Tsolere Arakelian, Gerben C. Zondag, Ramon Arens, Jeroen van Bergen, Ferry Ossendorp   +12 more
doaj   +1 more source

Early T Cell Recognition of B Cells following Epstein-Barr Virus Infection: Identifying Potential Targets for Prophylactic Vaccination.

PLoS Pathogens, 2016
Epstein-Barr virus, a B-lymphotropic herpesvirus, is the cause of infectious mononucleosis, has strong aetiologic links with several malignancies and has been implicated in certain autoimmune diseases. Efforts to develop a prophylactic vaccine to prevent
Jill M Brooks, Heather M Long, Rose J Tierney, Claire Shannon-Lowe, Alison M Leese, Martin Fitzpatrick, Graham S Taylor, Alan B Rickinson   +7 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites.

, 2006
Protective immune responses against malaria are induced by immunization with radiation-attenuated Plasmodium sporozoites. In contrast, non-viable, heat-killed sporozoites do not induce protection, emphasizing the requirement for live parasites to achieve
Morrot, Alexandre, Rai, Urvashi, Alexandre Morrot, Fidel Zavala, Hafalla, Julius CR, Rodriguez, Ana, Ana Rodriguez, Zavala, Fidel, Urvashi Rai, Dabeiba Bernal-Rubio, Bernal-Rubio, Dabeiba, Julius C. R. Hafalla   +11 more
core   +1 more source

Cd8 T‐cell recognition of human 5T4 oncofetal antigen [PDF]

International Journal of Cancer, 2006
AbstractThe 5T4 oncofetal antigen is expressed by a wide variety of human carcinomas, including colorectal, ovarian and gastric carcinomas. The restricted expression of 5T4 on tumor tissues as well as its implication in tumor progression and bad prognosis makes 5T4 a promising new candidate for immunotherapy.
Lucy J C, Smyth, Eyad, Elkord, Taher E I, Taher, Hui-Rong, Jiang, Deborah J, Burt, Alison, Clayton, Peter A, van Veelen, Arnoud, de Ru, Ferry, Ossendorp, Cornelis J M, Melief, Jan W, Drijfhout, Said, Dermime, Robert E, Hawkins, Peter L, Stern   +13 more
openaire   +2 more sources

Cooperation between Epstein-Barr virus immune evasion proteins spreads protection from CD8+ T cell recognition across all three phases of the lytic cycle.

PLoS Pathogens, 2014
CD8+ T cell responses to Epstein-Barr virus (EBV) lytic cycle expressed antigens display a hierarchy of immunodominance, in which responses to epitopes of immediate-early (IE) and some early (E) antigens are more frequently observed than responses to ...
Laura L Quinn, Jianmin Zuo, Rachel J M Abbott, Claire Shannon-Lowe, Rosemary J Tierney, Andrew D Hislop, Martin Rowe   +6 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

, 2002
CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days
Morrot, Alexandre, Gen-ichiro Sano, Alexandre Morrot, Maria A. Curotto de Lafaille, Fidel Zavala, Hafalla, Julius CR, Carvalho, Luzia H, Curotto de Lafaille, Maria A, Zavala, Fidel, Luzia H. Carvalho, Julius C.R. Hafalla, Sano, Gen-Ichiro   +11 more
core   +1 more source

Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion. [PDF]

, 2013
Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins.
Ameres, Stefanie, Schlott, F., Schlott, Fabian, Mautner, Josef, Michael Neuenhahn, Dirk H Busch, Mautner, J., Fabian Schlott, Josef Mautner (10677), Busch, D.H., Dirk H. Busch (125319), Busch, Dirk H., Neuenhahn, Michael, Moosmann, A., Plachter, B., Plachter, Bodo, Stefanie Ameres, Neuenhahn, M., Josef Mautner, Michael Neuenhahn (168944), Andreas Moosmann, Bodo Plachter, Stefanie Ameres (414946), Bodo Plachter (414948), Fabian Schlott (414947), Andreas Moosmann (38220), Ameres, S., Moosmann, Andreas   +27 more
core   +2 more sources

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes [PDF]

, 1990
Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain
Pavic, Ivica, Koszinowski, Ulrich H., Lucin, Pero, Rukavina, Daniel, Jonjic, Stipan   +4 more
core   +2 more sources