Results 51 to 60 of about 257,746 (309)

Induction of antigen specific intrahepatic CD8+ T cell responses by a secreted heat shock protein based gp96-Ig-PfCA malaria vaccine

Frontiers in Immunology, 2023
IntroductionA highly efficacious and durable vaccine against malaria is an essential tool for global malaria eradication. One of the promising strategies to develop such a vaccine is to induce robust CD8+ T cell mediated immunity against malaria liver ...
Laura Padula, Eva Fisher, Wathsala Wijayalath, Wathsala Wijayalath, Noelle B. Patterson, Noelle B. Patterson, Jun Huang, Jun Huang, Harini Ganeshan, Harini Ganeshan, Tanisha Robinson, Tanisha Robinson, François A. Bates, Margaret A. Hanson, Monica L. Martin, Katelyn Rivas, Denisse Garcia, Kimberly A. Edgel, Martha Sedegah, Eileen Villasante, Natasa Strbo   +20 more
doaj   +1 more source

PASD1: a promising target for the immunotherapy of haematological malignancies [PDF]

, 2013
In general, there is a lack of good immunotherapy targets within the spectrum of haematological malignancies. However haematopoietic stem cell transplants and continuing antigen discovery have allowed further insight into how further improvements in ...
Denniss, Frances, Guinn, Barbara-Ann, Khan, Ghazala, Mills, Ken I., Pulford, Karen   +4 more
core   +3 more sources

CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells

Nature Communications, 2022
CD4 and CD8 co-receptors are routinely used to define distinct functional and phenotypic lineages of T cells. Here the authors show CD4 and CD8 also modulate the functional avidity of the CD1b-restricted response to mycobacterial lipid ...
Charlotte A. James, Yuexin Xu, Melissa S. Aguilar, Lichen Jing, Erik D. Layton, Martine Gilleron, Adriaan J. Minnaard, Thomas J. Scriba, Cheryl L. Day, Edus H. Warren, David M. Koelle, Chetan Seshadri   +11 more
doaj   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
Alexander-Miller, Almeida, Appay, Berger, Betts, Bosselut, Cerundolo, Gallimore, Gorman, Hansen, Hollander, Homann, Jelley-Gibbs, Jenkins, Jones, Jones, Judge, Karrer, Kattan, Kedzierska, Kim, Kohlmeier, Lefranc, Liang, Moffat, Neveu, Norbury, Powell, Price, Quigley, Rangel-Moreno, Richards, Roberts, Schluns, Tan, Tough, Trautmann, Valkenburg, Valkenburg, Woodland, Wooldridge, Zammit   +41 more
core   +1 more source

Persistent Herpes Simplex Virus Type 1 Infection of Enteric Neurons Triggers CD8+ T Cell Response and Gastrointestinal Neuromuscular Dysfunction

Frontiers in Cellular and Infection Microbiology, 2021
Behind the central nervous system, neurotropic viruses can reach and persist even in the enteric nervous system (ENS), the neuronal network embedded in the gut wall.
Paola Brun, Jessica Conti, Veronica Zatta, Venera Russo, Melania Scarpa, Andromachi Kotsafti, Andrea Porzionato, Raffaele De Caro, Marco Scarpa, Matteo Fassan, Arianna Calistri, Ignazio Castagliuolo   +11 more
doaj   +1 more source

Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion. [PDF]

, 2013
Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins.
Ameres, Stefanie, Busch, Dirk H., Mautner, Josef, Moosmann, Andreas, Neuenhahn, Michael, Plachter, Bodo, Schlott, Fabian   +6 more
core   +3 more sources

Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination

Journal for ImmunoTherapy of Cancer, 2018
Background One of today’s greatest hurdles for cancer immunotherapy is the absence of information regarding which tumor antigens are already recognized by patients receiving immunotherapies, and whether those therapies then boost or generate an immune ...
Tyler W. Hulett, Shawn M. Jensen, Phillip A. Wilmarth, Ashok P. Reddy, Carmen Ballesteros-Merino, Michael E. Afentoulis, Christopher Dubay, Larry L. David, Bernard A. Fox   +8 more
doaj   +1 more source

Dendritic cell cross-priming is essential for immune responses to Listeria monocytogenes. [PDF]

PLoS ONE, 2009
Cross-presentation is now recognized as a major mechanism for initiating CD8 T cell responses to virus and tumor antigens in vivo. It provides an elegant mechanism that allows relatively few Dendritic cells (DCs) to initiate primary immune responses ...
Anna T Reinicke, Kyla D Omilusik, Genc Basha, Wilfred A Jefferies   +3 more
doaj   +1 more source

Cancer vaccines: uses of HLA transgenic mice compared to genetically modified mice [PDF]

, 2008
Many tumor antigens have been identified that can be targeted by the immune system. Animal models that have been genetically modified to express human HLA molecules instead of their own MHC antigens have shown to be valuable in the discovery of peptides ...
McArdle, SE
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source