Results 31 to 40 of about 459,921 (305)
Frontiers in Immunology, 2020 CD8+ T cells, the most abundant T cell subset in the decidua, play a critical role in the maintenance of pregnancy. The majority of decidual CD8+ T cells have an effector memory phenotype, while those in the peripheral blood display a naive phenotype. An
Keiko Morita +9 more
doaj +1 more source
Antigen delivery to dendritic cells shapes human CD4+ and CD8+ T cell memory responses to Staphylococcus aureus. [PDF]
PLoS Pathogens, 2017 Intracellular persistence of Staphylococcus aureus favors bacterial spread and chronic infections. Here, we provide evidence for the existence of human CD4+ and CD8+ T cell memory against staphylococcal antigens.
Julia Uebele +8 more
doaj +1 more source
JCI Insight, 2023 CD8+ T cells can recognize tumor antigens displayed by HLA class I molecules and eliminate tumor cells. Despite their low tumor mutation burden, immune checkpoint blockade (ICB) is often beneficial in patients with renal cell carcinoma (RCC). Here, using
Shin Kobayashi +8 more
doaj +1 more source
Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2015 To determine the antigenic determinants and specific molecular requirements for the generation of autoregulatory neuroantigen-specific CD8(+) T cells in models of multiple sclerosis (MS).We have previously shown that MOG35-55-specific CD8(+) T cells suppress experimental autoimmune encephalomyelitis (EAE) in the C57BL/6 model.
Ortega, Sterling B. +4 more
openaire +2 more sources
Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. [PDF]
, 2001 We generated T cell receptor transgenic mice specific for the liver stages of the rodent malaria parasite Plasmodium yoelii and studied the early events in the development of in vivo effector functions in antigen-specific CD8(+) T cells.
Lafaille, JJ +11 more
core +1 more source
Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection [PDF]
, 2011 The aim of this project was to compare the breadth and magnitude of CFP10 and ESAT6-specific CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific CD8 T ...
Moshi, Noell Dominika
core +1 more source
Frontiers in Immunology, 2021 Increasing evidence suggests that post-translational peptide splicing can play a role in the immune response under pathological conditions. This seems to be particularly relevant in Type 1 Diabetes (T1D) since post-translationally spliced epitopes ...
Michele Mishto +5 more
doaj +1 more source
Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria. [PDF]
, 2003 Following immunization with Plasmodium yoelii sporozoites, the CD8(+) T cell population specific for the SYVPSAEQI epitope expressed in sporozoite and liver stages of this malaria parasite revealed the existence of a short term Ag presentation process ...
Morrot, Alexandre +5 more
core +1 more source
Differential Kinetics of Antigen Dependency of CD4+ and CD8+ T Cells [PDF]
The Journal of Immunology, 2014 Abstract Ag recognition via the TCR is necessary for the expansion of specific T cells that then contribute to adaptive immunity as effector and memory cells. Because CD4+ and CD8+ T cells differ in terms of their priming APCs and MHC ligands we compared their requirements of Ag persistence during their expansion phase side by side ...
Rabenstein, H. +6 more
openaire +3 more sources
Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy. [PDF]
, 2007 Epstein-Barr virus (EBV) is associated with a number of human malignancies. EBV-positive post-transplant lymphoproliferative disease in solid organ and hematopoietic stem cell transplant recipients has been successfully treated by the adoptive transfer ...
Burdach, S. +36 more
core +1 more source