Results 31 to 40 of about 500,097 (256)

Hepatocellular carcinoma escapes immune surveillance through deceiving thymus into recalling peripheral activated CD8+ T cells

Neoplasia: An International Journal for Oncology Research
The role of thymic epithelial cells (TECs) in eliminating self-reactive T cells through the presentation of self-antigens is well-established. However, it remains unclear whether TECs can eliminate tumor-reactive CD8+ T cells by presenting tumor antigens.
Qiaoting Hu, Xuefeng Wang, Yundan You, Jun Liu, Bin Lan, Fangfang Chen, Hong Wen, Haili Cheng, Weibin Zhuo, Ting Xu, Jingxian Zheng, Yuchuan Jiang, Xiaojie Wang, Jing Lin, Zengqing Guo, Sha Huang, Gang Chen, Yu Chen, Jingfeng Liu   +18 more
doaj   +1 more source

Induction of antigen specific intrahepatic CD8+ T cell responses by a secreted heat shock protein based gp96-Ig-PfCA malaria vaccine

Frontiers in Immunology, 2023
IntroductionA highly efficacious and durable vaccine against malaria is an essential tool for global malaria eradication. One of the promising strategies to develop such a vaccine is to induce robust CD8+ T cell mediated immunity against malaria liver ...
Laura Padula, Eva Fisher, Wathsala Wijayalath, Wathsala Wijayalath, Noelle B. Patterson, Noelle B. Patterson, Jun Huang, Jun Huang, Harini Ganeshan, Harini Ganeshan, Tanisha Robinson, Tanisha Robinson, François A. Bates, Margaret A. Hanson, Monica L. Martin, Katelyn Rivas, Denisse Garcia, Kimberly A. Edgel, Martha Sedegah, Eileen Villasante, Natasa Strbo   +20 more
doaj   +1 more source

Persistent Herpes Simplex Virus Type 1 Infection of Enteric Neurons Triggers CD8+ T Cell Response and Gastrointestinal Neuromuscular Dysfunction

Frontiers in Cellular and Infection Microbiology, 2021
Behind the central nervous system, neurotropic viruses can reach and persist even in the enteric nervous system (ENS), the neuronal network embedded in the gut wall.
Paola Brun, Jessica Conti, Veronica Zatta, Venera Russo, Melania Scarpa, Andromachi Kotsafti, Andrea Porzionato, Raffaele De Caro, Marco Scarpa, Matteo Fassan, Arianna Calistri, Ignazio Castagliuolo   +11 more
doaj   +1 more source

HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.

, 2002
Few human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach.
Lukey, Pauline T, Abdulrahman S. Hammond, McAdam, Keith PWJ, Klein, Michèl R, Jaye, Assan, Smith, Steve M, Michèl R. Klein, Assan Jaye, Steve M. Smith, Hammond, Abdulrahman S, Pauline T. Lukey, Keith P. W. J. McAdam   +11 more
core   +1 more source

Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination

Journal for ImmunoTherapy of Cancer, 2018
Background One of today’s greatest hurdles for cancer immunotherapy is the absence of information regarding which tumor antigens are already recognized by patients receiving immunotherapies, and whether those therapies then boost or generate an immune ...
Tyler W. Hulett, Shawn M. Jensen, Phillip A. Wilmarth, Ashok P. Reddy, Carmen Ballesteros-Merino, Michael E. Afentoulis, Christopher Dubay, Larry L. David, Bernard A. Fox   +8 more
doaj   +1 more source

CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells

Nature Communications, 2022
CD4 and CD8 co-receptors are routinely used to define distinct functional and phenotypic lineages of T cells. Here the authors show CD4 and CD8 also modulate the functional avidity of the CD1b-restricted response to mycobacterial lipid ...
Charlotte A. James, Yuexin Xu, Melissa S. Aguilar, Lichen Jing, Erik D. Layton, Martine Gilleron, Adriaan J. Minnaard, Thomas J. Scriba, Cheryl L. Day, Edus H. Warren, David M. Koelle, Chetan Seshadri   +11 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

INNOVATIVE STRATEGIES TO IDENTIFY M. TUBERCULOSIS ANTIGENS AND EPITOPES USING GENOME-WIDE ANALYSES

Frontiers in Immunology, 2014
In view of the fact that only a small part of the Mtb expressome has been explored for identification of antigens capable of activating human T-cell responses, which is critically required for the design of better TB vaccination strategies, more emphasis
Annemieke eGeluk, Krista E van Meijgaarden, Simone A Joosten, Susanna eCommandeur, Susanna eCommandeur, Tom H.M. Ottenhoff   +5 more
doaj   +1 more source

Allogeneic ADSCs Induce the Production of Alloreactive Memory-CD8 T Cells through HLA-ABC Antigens

Cells, 2020
We investigated the immunogenicity of allogeneic human adipose-derived mesenchymal stem cells (ADSCs) through the production of alloreactive-CD8 T and -memory CD8 T cells, based on their human leukocyte antigen (HLA) expression.
Sung-Ho Chang, Hyun Je Kim, Chung-Gyu Park   +2 more
doaj   +1 more source