Results 31 to 40 of about 174,472 (265)

Differential Kinetics of Antigen Dependency of CD4+ and CD8+ T Cells [PDF]

The Journal of Immunology, 2014
Abstract Ag recognition via the TCR is necessary for the expansion of specific T cells that then contribute to adaptive immunity as effector and memory cells. Because CD4+ and CD8+ T cells differ in terms of their priming APCs and MHC ligands we compared their requirements of Ag persistence during their expansion phase side by side ...
Rabenstein, H., Behrendt, A., Ellwart, J., Naumann, R., Horsch, M., Beckers, J., Obst, R.   +6 more
openaire   +3 more sources

Potential Mimicry of Viral and Pancreatic β Cell Antigens Through Non-Spliced and cis-Spliced Zwitter Epitope Candidates in Type 1 Diabetes

Frontiers in Immunology, 2021
Increasing evidence suggests that post-translational peptide splicing can play a role in the immune response under pathological conditions. This seems to be particularly relevant in Type 1 Diabetes (T1D) since post-translationally spliced epitopes ...
Michele Mishto, Michele Mishto, Artem Mansurkhodzhaev, Teresa Rodriguez-Calvo, Teresa Rodriguez-Calvo, Juliane Liepe   +5 more
doaj   +1 more source

Cutting Edge: Antigen-Independent CD8 T Cell Proliferation [PDF]

The Journal of Immunology, 2001
Abstract Recent analyses of CD8 T cell responses to Listeria monocytogenes infection demonstrate that the duration of in vivo T cell proliferation is not determined by the amount or duration of Ag presentation. However, the extent to which T lymphocytes are capable of proliferating in the absence of Ag is unknown.
P, Wong, E G, Pamer
openaire   +2 more sources

Cd8 T‐cell recognition of human 5T4 oncofetal antigen [PDF]

International Journal of Cancer, 2006
AbstractThe 5T4 oncofetal antigen is expressed by a wide variety of human carcinomas, including colorectal, ovarian and gastric carcinomas. The restricted expression of 5T4 on tumor tissues as well as its implication in tumor progression and bad prognosis makes 5T4 a promising new candidate for immunotherapy.
Lucy J C, Smyth, Eyad, Elkord, Taher E I, Taher, Hui-Rong, Jiang, Deborah J, Burt, Alison, Clayton, Peter A, van Veelen, Arnoud, de Ru, Ferry, Ossendorp, Cornelis J M, Melief, Jan W, Drijfhout, Said, Dermime, Robert E, Hawkins, Peter L, Stern   +13 more
openaire   +2 more sources

An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes: Is There Relevance for Vaccine Development?

Frontiers in Immunology, 2017
Efficient and safe induction of CD8+ T cell responses is a desired characteristic of vaccines against intracellular pathogens. To achieve this, a new generation of safe vaccines is being developed accommodating single, dominant antigens of pathogens of ...
Anouk C. M. Platteel, Juliane Liepe, Willem van Eden, Michele Mishto, Michele Mishto, Michele Mishto, Alice J. A. M. Sijts   +6 more
doaj   +1 more source

Hepatocellular carcinoma escapes immune surveillance through deceiving thymus into recalling peripheral activated CD8+ T cells

Neoplasia: An International Journal for Oncology Research
The role of thymic epithelial cells (TECs) in eliminating self-reactive T cells through the presentation of self-antigens is well-established. However, it remains unclear whether TECs can eliminate tumor-reactive CD8+ T cells by presenting tumor antigens.
Qiaoting Hu, Xuefeng Wang, Yundan You, Jun Liu, Bin Lan, Fangfang Chen, Hong Wen, Haili Cheng, Weibin Zhuo, Ting Xu, Jingxian Zheng, Yuchuan Jiang, Xiaojie Wang, Jing Lin, Zengqing Guo, Sha Huang, Gang Chen, Yu Chen, Jingfeng Liu   +18 more
doaj   +1 more source

Induction of antigen specific intrahepatic CD8+ T cell responses by a secreted heat shock protein based gp96-Ig-PfCA malaria vaccine

Frontiers in Immunology, 2023
IntroductionA highly efficacious and durable vaccine against malaria is an essential tool for global malaria eradication. One of the promising strategies to develop such a vaccine is to induce robust CD8+ T cell mediated immunity against malaria liver ...
Laura Padula, Eva Fisher, Wathsala Wijayalath, Wathsala Wijayalath, Noelle B. Patterson, Noelle B. Patterson, Jun Huang, Jun Huang, Harini Ganeshan, Harini Ganeshan, Tanisha Robinson, Tanisha Robinson, François A. Bates, Margaret A. Hanson, Monica L. Martin, Katelyn Rivas, Denisse Garcia, Kimberly A. Edgel, Martha Sedegah, Eileen Villasante, Natasa Strbo   +20 more
doaj   +1 more source

Spatial coordination of CD8 and TCR molecules controls antigen recognition by CD8⁺ T‐cells

FEBS Letters, 2005
The interactions between the TCR and peptides bound to class I MHC encoded molecules (pMHC) and a mechanism for CD8 cooperation in this process are reviewed. Observation of two TCR/CD8 populations with different lateral diffusion rate constants as well as two distinct association phases of class I MHC tetramers ((pMHC)4) with T‐cells suggest that the ...
Pecht, Israel, Gakamsky, Dmitry M.
openaire   +2 more sources

Persistent Herpes Simplex Virus Type 1 Infection of Enteric Neurons Triggers CD8+ T Cell Response and Gastrointestinal Neuromuscular Dysfunction

Frontiers in Cellular and Infection Microbiology, 2021
Behind the central nervous system, neurotropic viruses can reach and persist even in the enteric nervous system (ENS), the neuronal network embedded in the gut wall.
Paola Brun, Jessica Conti, Veronica Zatta, Venera Russo, Melania Scarpa, Andromachi Kotsafti, Andrea Porzionato, Raffaele De Caro, Marco Scarpa, Matteo Fassan, Arianna Calistri, Ignazio Castagliuolo   +11 more
doaj   +1 more source

CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells

Nature Communications, 2022
CD4 and CD8 co-receptors are routinely used to define distinct functional and phenotypic lineages of T cells. Here the authors show CD4 and CD8 also modulate the functional avidity of the CD1b-restricted response to mycobacterial lipid ...
Charlotte A. James, Yuexin Xu, Melissa S. Aguilar, Lichen Jing, Erik D. Layton, Martine Gilleron, Adriaan J. Minnaard, Thomas J. Scriba, Cheryl L. Day, Edus H. Warren, David M. Koelle, Chetan Seshadri   +11 more
doaj   +1 more source