Results 31 to 40 of about 257,746 (309)

Cognate Antigen Stimulation Generates Potent CD8+ Inflammatory Effector T Cells [PDF]

Frontiers in Immunology, 2013
Inflammatory reactions are believed to be triggered by innate signals and have a major protective role by recruiting innate immunity cells, favoring lymphocyte activation and differentiation, and thus contributing to the sequestration and elimination of the injurious stimuli.
Hsueh-Cheng Sung, Sara Lemos, Patricia Ribeiro-Santos, Kateryna Kozyrytska, Florence Vasseur, Agnès Legrand, Alain Charbit, Benedita Rocha, César Evaristo   +8 more
openaire   +3 more sources

Cytotoxic CD8⁺T cells target citrullinated antigens in rheumatoid arthritis

Nature Communications, 2022
AbstractThe immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis (RA) remain poorly defined. Although increased levels of CD8+T cells have been described in RA, their role in pathogenesis remains unclear. Here we perform single cell transcriptome and T cell receptor (TCR) sequencing of CD8+T cells derived from anti ...
Jae-Seung Moon, Shady Younis, Nitya S. Ramadoss, Radhika Iyer, Khushboo Sheth, Orr Sharpe, Navin L. Rao, Stephane Becart, Julie A. Carman, Eddie A. James, Jane H. Buckner, Kevin D. Deane, V. Michael Holers, Susan M. Goodman, Laura T. Donlin, Mark M. Davis, William H. Robinson   +16 more
openaire   +3 more sources

Proteogenomic identification of an immunogenic antigen derived from human endogenous retrovirus in renal cell carcinoma

JCI Insight, 2023
CD8+ T cells can recognize tumor antigens displayed by HLA class I molecules and eliminate tumor cells. Despite their low tumor mutation burden, immune checkpoint blockade (ICB) is often beneficial in patients with renal cell carcinoma (RCC). Here, using
Shin Kobayashi, Serina Tokita, Keigo Moniwa, Katsuyuki Kitahara, Hiromichi Iuchi, Kazuhiko Matsuo, Hidehiro Kakizaki, Takayuki Kanaseki, Toshihiko Torigoe   +8 more
doaj   +1 more source

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose [PDF]

Proceedings of the National Academy of Sciences, 1999
There are two major mechanisms reported to prevent the autoreactivity of islet-specific CD8+T cells: ignorance and tolerance. When ignorance is operative, naïve autoreactive CD8+T cells ignore islet antigens and recirculate without causing damage, unless activated by an external stimulus. In the case of tolerance, CD8+T cells are deleted.
C, Kurts, R M, Sutherland, G, Davey, M, Li, A M, Lew, E, Blanas, F R, Carbone, J F, Miller, W R, Heath   +8 more
openaire   +2 more sources

Antigen delivery to dendritic cells shapes human CD4+ and CD8+ T cell memory responses to Staphylococcus aureus. [PDF]

PLoS Pathogens, 2017
Intracellular persistence of Staphylococcus aureus favors bacterial spread and chronic infections. Here, we provide evidence for the existence of human CD4+ and CD8+ T cell memory against staphylococcal antigens.
Julia Uebele, Christoph Stein, Minh-Thu Nguyen, Anja Schneider, Franziska Kleinert, Olga Tichá, Gabriele Bierbaum, Friedrich Götz, Isabelle Bekeredjian-Ding   +8 more
doaj   +1 more source

Tumor derived Microvesicles enhance cross-processing ability of clinical grade Dendritic Cells [PDF]

, 2018
Tumor cells release extracellular microvesicles (MVs) in the microenvironment to deliver biological signals to neighbouring cells as well as to cells in distant tissues.
Battisti, Federico, Belleudi, Francesca, Claudia De Archangelis,, DI FILIPPO, Alessandra, Dionisi, Marco, Napoletano, Chiara, Nuti, Marianna, RAHIMI KOSHKAKI, Hassan, Rughetti, Aurelia, Ruscito, Ilary, Torrisi, Maria Rosaria, Zizzari, ILARIA GRAZIA   +11 more
core   +1 more source

Quantitation of antigen-specific CD8+ T-cell responses

Immunology Letters, 1999
Enumeration of antigen-specific CD8+ T-cells has traditionally been largely dependent on the use of techniques that require a period of expansion in vitro. However the recent emergence of methods that can be used directly ex vivo to quantify antigen-specific CD8+ T cells has prompted a re-evaluation of the magnitude of viral-specific cellular immune ...
Ogg, G, Mcmichael, A
openaire   +2 more sources

CD8+ T-cell responses in vaccination: Reconsidering targets and function in the context of chronic antigen stimulation [PDF]

, 2018
Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines.
Cosma, Gabriela L., Eisenlohr, Laurence
core   +2 more sources

MHC-based detection of antigen-specific CD8+ T cell responses [PDF]

Cancer Immunology, Immunotherapy, 2010
The hallmark of adaptive immunity is its ability to recognise a wide range of antigens and technologies that capture this diversity are therefore of substantial interest. New methods have recently been developed that allow the parallel analysis of T cell reactivity against vast numbers of different epitopes in limited biological material.
Hadrup, Sine Reker, Schumacher, Ton N.
openaire   +2 more sources

Activated integrins identify functional antigen-specific CD8⁺T cells within minutes after antigen stimulation [PDF]

Proceedings of the National Academy of Sciences, 2018
SignificanceAssessing antigen-specific T cells is crucial for our understanding of immune reactions against pathogens and tumors, and for evaluating immunotherapies in patients. Existing techniques to evaluate the functionality of T lymphocytes all rely on de novo expression of proteins, typically intracellular cytokines, and therefore require ...
Dimitrov, Stoyan, Gouttefangeas, Cécile, Besedovsky, Luciana, Jensen, Anja T R, Chandran, P Anoop, Rusch, Elisa, Businger, Ramona, Schindler, Michael, Lange, Tanja, Born, Jan, Rammensee, Hans-Georg   +10 more
openaire   +5 more sources