Comprehensive definition of human immunodominant CD8 antigens in tuberculosis. [PDF]
NPJ Vaccines, 2017 AbstractDespite widespread use of the Bacillus Calmette-Guerin vaccine, tuberculosis, caused by infection with Mycobacterium tuberculosis, remains a leading cause of morbidity and mortality worldwide. As CD8+ T cells are critical to tuberculosis host defense and a phase 2b vaccine trial of modified vaccinia Ankara expressing Ag85a that failed to ...
Lewinsohn DA +18 more
europepmc +4 more sources
Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B. [PDF]
PLoS Pathogens, 2007 CD8(+) T cells are essential for host defense to intracellular bacterial pathogens such as Mycobacterium tuberculosis (Mtb), Salmonella species, and Listeria monocytogenes, yet the repertoire and dominance pattern of human CD8 antigens for these ...
Deborah A Lewinsohn +9 more
doaj +4 more sources
CD8 memory, immunodominance, and antigenic escape [PDF]
European Journal of Immunology, 2000 Previous theoretical work has suggested that efficient virus control or clearance requires antigen-independent persistence of memory cytotoxic T lymphocyte precursors (CTLp), and that failure to generate such memory CTLp can result in persistent infection and eventual loss of virus control.
D, Wodarz, M A, Nowak
openaire +2 more sources
Antigens for CD4 and CD8 T Cells in Tuberculosis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4(+) and CD8(+) T cells play an important role in host defense to TB.
Cecilia S, Lindestam Arlehamn +3 more
openaire +2 more sources
Signals for antigen-independent differentiation of memory CD8+ T cells [PDF]
Cellular and Molecular Life Sciences, 2021 AbstractConventional CD8+ memory T cells develop upon stimulation with foreign antigen and provide increased protection upon re-challenge. Over the past two decades, new subsets of CD8+ T cells have been identified that acquire memory features independently of antigen exposure.
Eliza Mari Kwesi-Maliepaard +2 more
openaire +3 more sources
Modulation of CD8 and CD3 by HIV or HIV Antigens [PDF]
Scandinavian Journal of Immunology, 2001 To investigate whether human immunodeficiency virus (HIV)‐1 and HIV‐1 antigens modulate surface and cytoplasmic CD8 or CD3, as well as CD4, we used cell permeabilization reagents, surface/cytoplasmic fluorescent staining, multiparameter flow cytometric techniques and an in vitro culture system in which relatively few lymphocytes are actively infected ...
J, Jason, K L, Inge
openaire +2 more sources
Antigenic Epitopes Regulate the Phenotype of CD8+ CTL Primed by Exogenous Antigens [PDF]
The Journal of Immunology, 2000 Abstract We previously reported that insulin-specific, MHC class I-restricted CTL precursors can be primed by injecting C57BL/6 mice with bovine insulin in CFA. These bovine insulin-primed CTL displayed a type 0 CTL phenotype, producing IL-4, IL-5, IL-10, low levels of IFN-γ, but no TNF-α.
H, Ma, J A, Kapp
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Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection [PDF]
, 2002 Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in
Ogg, GS +29 more
core +1 more source
CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen:Implications for parasite strain-specific immunity [PDF]
, 2009 Although immunodominance of CD8(+) T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear.
Connelley, T. +44 more
core +1 more source
Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection [PDF]
, 2005 CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Gotto, J +19 more
core +1 more source