Results 11 to 20 of about 500,097 (256)

Comprehensive definition of human immunodominant CD8 antigens in tuberculosis. [PDF]

NPJ Vaccines, 2017
Despite widespread use of the Bacillus Calmette-Guerin vaccine, tuberculosis, caused by infection with Mycobacterium tuberculosis, remains a leading cause of morbidity and mortality worldwide. As CD8+ T cells are critical to tuberculosis host defense and
Lewinsohn DA, Swarbrick GM, Park B, Cansler ME, Null MD, Toren KG, Baseke J, Zalwango S, Mayanja-Kizza H, Malone LL, Nyendak M, Wu G, Guinn K, McWeeney S, Mori T, Chervenak KA, Sherman DR, Boom WH, Lewinsohn DM.   +18 more
europepmc   +2 more sources

Characterisation of CD8neg and CD8+ human natural killer cell subsets [PDF]

, 2012
NK cells are CD3neg CD56+ lymphocytes that constitute about 10-15% of peripheral blood lymphocytes. They have an innate ability to recognise and kill virus infected cells and tumour cells.
Abdalla, Ibrahim.I.I.
core   +5 more sources

Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection [PDF]

, 2002
Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in
Antonio Bertoletti, Brown, D., Dusheiko, G., Geoff Dusheiko, Williams, R., George J.M. Webster, Webster, G.J.M., David Brown, Mala K. Maini, Stephanie Reignat, King, A., Suranjith L. Seneviratne, Roger Williams, Bertoletti, A., Reignat, S., Maini, M.K., Graham S. Ogg, Abigail King, Ogg, G.S., Seneviratne, S.L.   +19 more
core   +1 more source

CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen:Implications for parasite strain-specific immunity [PDF]

, 2009
Although immunodominance of CD8(+) T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear.
Connelley, T., Burrells, A, W. Ivan Morrison, Declan J. McKeever, Connelley, Timothy, Taracha, Evans L., Connelly, T, McKeever, DJ, Morrison, WI, Simon P. Graham, Burrells, A., MacHugh, ND, McKeever, D J, Taracha, E.L.N., Niall D. MacHugh, Roger Pelle, Ellis, SA, McKeever, Declan J., MacHugh, N D, Connelley, T, Evans L. Taracha, Ellis, S A, Graham, SP, Pelle, Roger, Ellis, Shirley A., MacHugh, Niall D., Formisano, Principia, Formisano, P, Principia Formisano, Taracha, EL, Ellis, S.A., Shirley A. Ellis, Taracha, E L, Alison Burrells, Pelle, R, Graham, Simon P., Graham, S P, Timothy Connelley, Formisano, P., Morrison, W. Ivan, Burrells, Alison, Graham, S.P.   +41 more
core   +1 more source

Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection [PDF]

, 2005
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Gotto, J, Ornella Franzese, Antonio Bertoletti, Maini, Mk, Franzese, O., Williams, R., Adam J. Gehring, Gehring, A.J., Roger Williams, Gehring, Aj, Gotto, J., Bertoletti, A., Kennedy, P.T.F., Williams, R, Maini, M.K., Patrick T. F. Kennedy, Kennedy, Ptf, Jim Gotto, Mala K. Maini, FRANZESE, ORNELLA   +19 more
core   +1 more source

Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity [PDF]

, 2011
<p><b>Background:</b> Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer).
Taracha, E. L. N., Mwangi Duncan M., Graham Simon P., Paul R. Spooner, Graham, S. P., Saya, RM, Toye, PG, Njahira, Moses N., Pelle, R., Richard P Bishop, Musoke, AJ, Silva, J., Rosemary M. Saya, Philip G Toye, Toye Philip G., Njahira, M.N., Saya, R. A., Evans L. N. Taracha, Musoke, A. J., Pelle Roger, Odongo, DO, Silva Joana C., Roger Pelle, Musoke Anthony J., Morrison, Ivan, Weir, W., Silva, J.C., Anthony J. Musoke, Joana C Silva, Graham, SP, Bishop, Richard P., Odongo, David O., Simon P Graham, Paul R Spooner, Taracha, EL, Morrison W. Ivan, Pelle, R, Bishop, R.P., Toye, P. G., Moses N Njahira, Saya Rosemary M., Duncan M. Mwangi, Spooner, P.R., Osaso Julius, Mwangi, D.M., W. Ivan Morrison, Toye, P.G., Silva, J. C., David O. Odongo, Osaso, J, Morrison, WI, Simon P. Graham, Moses N. Njahira, Mwangi, D. M., Evans L N Taracha, Taracha Evans L. N., Mwangi, DM, Odongo, D.O., Taracha, E.L.N., Bishop, RP, Morrison, W.I., Bishop, R. P., Njahira, M. N., Saya, R.M., Spooner, PR, Musoke, A.J., Saya, Rosemary M., Spooner, P. R., Richard P. Bishop, Pelle, Roger, Mwangi, David Miano, Spooner Paul R., Rosemary M Saya, Odongo David O., Njahira, MN, Joana C. Silva, Odongo, D. O., Duncan M Mwangi, Julius Osaso, W Ivan Morrison, Toye, Philip G., Njahira Moses N., Philip G. Toye, Morrison, W. Ivan, David O Odongo, Weir William, Bishop Richard P., Silva, JC, Osaso, J., Anthony J Musoke, Graham, S.P., William Weir, Weir, W   +92 more
core   +1 more source

Tissue signatures influence the activation of intrahepatic CD8+ T cells against malaria sporozoites

Frontiers in Microbiology, 2014
Plasmodium sporozoites and liver stages express antigens that are targeted to the MHC-Class I antigen-processing pathway. After the introduction of Plasmodium sporozoites by Anopheles mosquitoes, bone marrow-derived dendritic cells in skin-draining lymph
Alexandre eMorrot, Mauricio Martins eRodrigues   +1 more
doaj   +1 more source

Profiling the Targets of Protective CD8+ T Cell Responses to Infection

Molecular Therapy: Methods & Clinical Development, 2017
T cells are critical effectors of host immunity that target intracellular pathogens, such as the causative agents of HIV, tuberculosis, and malaria.
Joseph T. Bruder, Ping Chen, Greg Ekberg, Emily C. Smith, Christopher A. Lazarski, Bennett A. Myers, Jessica Bolton, Martha Sedegah, Eileen Villasante, Thomas L. Richie, C. Richter King, Joao C. Aguiar, Denise L. Doolan, Douglas E. Brough   +13 more
doaj   +1 more source

In-depth analysis of human virus-specific CD8+ T cells delineates unique phenotypic signatures for T cell specificity prediction

Cell Reports, 2023
Summary: Following viral infection, the human immune system generates CD8+ T cell responses to virus antigens that differ in specificity, abundance, and phenotype.
Florian Schmidt, Hannah F. Fields, Yovita Purwanti, Ana Milojkovic, Syazwani Salim, Kan Xing Wu, Yannick Simoni, Antonella Vitiello, Daniel T. MacLeod, Alessandra Nardin, Evan W. Newell, Katja Fink, Andreas Wilm, Michael Fehlings   +13 more
doaj   +1 more source

CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment

Cells, 2021
The scanning of surrounding tissues by T lymphocytes to detect cognate antigens requires high speed, sensitivity and specificity. T-cell receptor (TCR) co-receptors such as CD8 increase detection performance, but the exact mechanism remains incompletely ...
Philippe Robert, Laurent Limozin, P. Anton van der Merwe, Pierre Bongrand   +3 more
doaj   +1 more source