Results 11 to 20 of about 174,472 (265)

Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B. [PDF]

PLoS Pathogens, 2007
CD8(+) T cells are essential for host defense to intracellular bacterial pathogens such as Mycobacterium tuberculosis (Mtb), Salmonella species, and Listeria monocytogenes, yet the repertoire and dominance pattern of human CD8 antigens for these ...
Deborah A Lewinsohn, Ervina Winata, Gwendolyn M Swarbrick, Katie E Tanner, Matthew S Cook, Megan D Null, Meghan E Cansler, Alessandro Sette, John Sidney, David M Lewinsohn   +9 more
doaj   +4 more sources

Comprehensive definition of human immunodominant CD8 antigens in tuberculosis. [PDF]

NPJ Vaccines, 2017
AbstractDespite widespread use of the Bacillus Calmette-Guerin vaccine, tuberculosis, caused by infection with Mycobacterium tuberculosis, remains a leading cause of morbidity and mortality worldwide. As CD8+ T cells are critical to tuberculosis host defense and a phase 2b vaccine trial of modified vaccinia Ankara expressing Ag85a that failed to ...
Lewinsohn DA, Swarbrick GM, Park B, Cansler ME, Null MD, Toren KG, Baseke J, Zalwango S, Mayanja-Kizza H, Malone LL, Nyendak M, Wu G, Guinn K, McWeeney S, Mori T, Chervenak KA, Sherman DR, Boom WH, Lewinsohn DM.   +18 more
europepmc   +4 more sources

CD8 memory, immunodominance, and antigenic escape [PDF]

European Journal of Immunology, 2000
Previous theoretical work has suggested that efficient virus control or clearance requires antigen-independent persistence of memory cytotoxic T lymphocyte precursors (CTLp), and that failure to generate such memory CTLp can result in persistent infection and eventual loss of virus control.
D, Wodarz, M A, Nowak
openaire   +2 more sources

Signals for antigen-independent differentiation of memory CD8+ T cells [PDF]

Cellular and Molecular Life Sciences, 2021
AbstractConventional CD8+ memory T cells develop upon stimulation with foreign antigen and provide increased protection upon re-challenge. Over the past two decades, new subsets of CD8+ T cells have been identified that acquire memory features independently of antigen exposure.
Eliza Mari Kwesi-Maliepaard, Heinz Jacobs, Fred van Leeuwen   +2 more
openaire   +3 more sources

Antigens for CD4 and CD8 T Cells in Tuberculosis [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4(+) and CD8(+) T cells play an important role in host defense to TB.
Cecilia S, Lindestam Arlehamn, David, Lewinsohn, Alessandro, Sette, Deborah, Lewinsohn   +3 more
openaire   +2 more sources

Modulation of CD8 and CD3 by HIV or HIV Antigens [PDF]

Scandinavian Journal of Immunology, 2001
To investigate whether human immunodeficiency virus (HIV)‐1 and HIV‐1 antigens modulate surface and cytoplasmic CD8 or CD3, as well as CD4, we used cell permeabilization reagents, surface/cytoplasmic fluorescent staining, multiparameter flow cytometric techniques and an in vitro culture system in which relatively few lymphocytes are actively infected ...
J, Jason, K L, Inge
openaire   +2 more sources

Antigenic Epitopes Regulate the Phenotype of CD8+ CTL Primed by Exogenous Antigens [PDF]

The Journal of Immunology, 2000
Abstract We previously reported that insulin-specific, MHC class I-restricted CTL precursors can be primed by injecting C57BL/6 mice with bovine insulin in CFA. These bovine insulin-primed CTL displayed a type 0 CTL phenotype, producing IL-4, IL-5, IL-10, low levels of IFN-γ, but no TNF-α.
H, Ma, J A, Kapp
openaire   +2 more sources

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose [PDF]

Proceedings of the National Academy of Sciences, 1999
There are two major mechanisms reported to prevent the autoreactivity of islet-specific CD8+T cells: ignorance and tolerance. When ignorance is operative, naïve autoreactive CD8+T cells ignore islet antigens and recirculate without causing damage, unless activated by an external stimulus. In the case of tolerance, CD8+T cells are deleted.
C, Kurts, R M, Sutherland, G, Davey, M, Li, A M, Lew, E, Blanas, F R, Carbone, J F, Miller, W R, Heath   +8 more
openaire   +2 more sources

Differences in antigen recognition and cytolytic activity of CD8⁺and CD8⁻T cells that express the same antigen-specific receptor [PDF]

Proceedings of the National Academy of Sciences, 2001
CD8+and CD8−T cell lines expressing the same antigen-specific receptor [the 2C T cell receptor (TCR)] were compared for ability to bind soluble peptide-MHC and to lyse target cells. The 2C TCR on CD8−cells bound a syngeneic MHC (Kb+)-peptide complex 10–100 times less well than the same TCR on CD8+cells, and the CD8−2C cells lysed target cells ...
B K, Cho, K C, Lian, P, Lee, A, Brunmark, C, McKinley, J, Chen, D M, Kranz, H N, Eisen   +7 more
openaire   +2 more sources

Profiling the Targets of Protective CD8+ T Cell Responses to Infection

Molecular Therapy: Methods & Clinical Development, 2017
T cells are critical effectors of host immunity that target intracellular pathogens, such as the causative agents of HIV, tuberculosis, and malaria.
Joseph T. Bruder, Ping Chen, Greg Ekberg, Emily C. Smith, Christopher A. Lazarski, Bennett A. Myers, Jessica Bolton, Martha Sedegah, Eileen Villasante, Thomas L. Richie, C. Richter King, Joao C. Aguiar, Denise L. Doolan, Douglas E. Brough   +13 more
doaj   +1 more source