Results 1 to 10 of about 103,262 (120)

The Effect of Immunosuppressive Adjuvant Kynurenine on Type 1 Diabetes Vaccine

Frontiers in Immunology, 2021
Inducing antigen-specific tolerance is a promising treatment for preventing or reversing Type 1 diabetes (T1D). In contrast to a vaccine that induces immune responses against pathogens, a tolerogenic vaccine can suppress immunity against antigens causing
Jing Sun, Jiandong Shi, Jianfang Li, Meini Wu, Yanhan Li, Sengquan Jia, Chunli Ma, Chunli Ma, Xinyi Wang, Zhiyuan Li, Zhiyuan Li, Ningzhu Hu, Yunzhang Hu   +12 more
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The role of immune checkpoints in cardiovascular disease

Frontiers in Pharmacology, 2022
Immune checkpoint inhibitors (ICI) are monoclonal antibodies which bind to immune checkpoints (IC) and their ligands to prevent inhibition of T-cell activation by tumor cells.
Laura I. Yousif, Anniek A. Tanja, Rudolf A. de Boer, Arco J. Teske, Wouter C. Meijers   +4 more
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Assessing in vitro and in vivo Trogocytosis By Murine CD4+ T cells

Bio-Protocol, 2020
Recognition of antigens by lymphocytes (B, T, and NK) on the surface of an antigen-presenting cell (APC) leads to lymphocyte activation and the formation of an immunological synapse between the lymphocyte and the APC.
Jim Reed, Scott Wetzel
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Standardization of Workflow and Flow Cytometry Panels for Quantitative Expression Profiling of Surface Antigens on Blood Leukocyte Subsets: An HCDM CDMaps Initiative

Frontiers in Immunology, 2022
BackgroundThe Human Cell Differentiation Molecules (HCDM) organizes Human Leukocyte Differentiation Antigen (HLDA) workshops to test and name clusters of antibodies that react with a specific antigen.
Daniela Kužílková, Joan Puñet-Ortiz, Pei M. Aui, Javier Fernández, Karel Fišer, Pablo Engel, Menno C. van Zelm, Menno C. van Zelm, Tomáš Kalina   +8 more
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Activation of interferon regulatory factor 3 by replication-competent vaccinia viruses improves antitumor efficacy mediated by T cell responses

Molecular Therapy: Oncolytics, 2021
Recently, oncolytic vaccinia viruses (VACVs) have shown their potential to provide for clinically effective cancer treatments. The reason for this clinical usefulness is not only the direct destruction of infected cancer cells but also activation of ...
Stephanie Riederer, Robert Fux, Michael H. Lehmann, Asisa Volz, Gerd Sutter, Juan J. Rojas   +5 more
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Pediatric psoriasis: from immunogenetics to targeted therapies [PDF]

Anais Brasileiros de Dermatologia
Background: Pediatric psoriasis may result in significant cumulative life course impairment, and there is comparatively less evidence available than for adult psoriasis.
Adriana Schikiera Martinelli Salathiel, Elisa Nunes Secamilli, Marina Gagheggi Maciel, Juliana Yumi Massuda Serrano, Andrea Fernandes Eloy da Costa França, Renata Ferreira Magalhães   +5 more
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Genetic deletion of Mst1 alters T cell function and protects against autoimmunity. [PDF]

PLoS ONE, 2014
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking.
Konstantin V Salojin, Brian D Hamman, Wei Chun Chang, Kanchan G Jhaver, Amin Al-Shami, Jeannette Crisostomo, Carrie Wilkins, Ann Marie Digeorge-Foushee, Jason Allen, Nita Patel, Suma Gopinathan, Julia Zhou, Amr Nouraldeen, Theodore C Jessop, Jeffrey T Bagdanoff, David J Augeri, Robert Read, Peter Vogel, Jonathan Swaffield, Alan Wilson, Kenneth A Platt, Kenneth G Carson, Alan Main, Brian P Zambrowicz, Tamas Oravecz   +24 more
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The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells

Frontiers in Immunology, 2019
Adaptor proteins contribute to the selection, differentiation and activation of natural killer T (NKT) cells, an innate(-like) lymphocyte population endowed with powerful immunomodulatory properties.
Evelyn Gerth, Jochen Mattner
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Diversification of Antitumour Immunity in a Patient with Metastatic Melanoma Treated with Ipilimumab and an IDO-Silenced Dendritic Cell Vaccine

Case Reports in Medicine, 2016
Indoleamine 2,3-dioxygenase (IDO) expression in dendritic cells (DCs) inhibits T-cell activation and promotes T-cell differentiation into regulatory T-cells.
Mouldy Sioud, Marta Nyakas, Stein Sæbøe-Larssen, Anne Mobergslien, Steinar Aamdal, Gunnar Kvalheim   +5 more
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ZINC DEFICIENCY INDUCES FAS-MEDIATED APOPTOSIS

Медицинская иммунология, 2014
. The aim of the present research was to study the expression of Fas-receptor and differentiation antigens CD3, CD4, CD8, CD16, CD20 on mononuclear cells of peripheral blood in the group of people with asimptomatic Zn-deficiency caused by geochemical ...
L. M. Karzakova
doaj   +1 more source