Results 11 to 20 of about 11,845,318 (301)

Expression of the CD6 T lymphocyte differentiation antigen in normal human brain [PDF]

Journal of Neuroimmunology, 1990
Antigens shared by the immune and central nervous systems (CNS) have been described repeatedly.The present study reports the expression of the CD6 lymphocyte differentiation antigen in normal humanbrain evidenced by immunohistochemistry and Northern blot analysis.
Mayer, Barbara, Funke, Ilona, Seed, Brian, Riethmüller, Gert, Weiss, Elisabeth H.   +4 more
openaire   +5 more sources

Incomplete Cd8+ T Lymphocyte Differentiation as a Mechanism for Subdominant Cytotoxic T Lymphocyte Responses to a Viral Antigen [PDF]

The Journal of Experimental Medicine, 2000
CD8+ cytotoxic T lymphocytes (CTLs) recognize antigen in the context of major histocompatibility complex (MHC) class I molecules. Class I epitopes have been classified as dominant or subdominant depending on the magnitude of the CTL response to the epitope.
Spencer, Juliet V, Braciale, Thomas J
openaire   +3 more sources

Acquisition of cytotoxic T lymphocyte-specific carbohydrate differentiation antigens. [PDF]

The Journal of experimental medicine, 1985
Cytotoxic T cell (CTL)-specific activation antigens, termed CT determinants, have been detected by monoclonal antibodies (mAb) that inhibit CTL function. At the cell surface, the CT antigens are associated with the T200 glycoproteins and two other proteins of Mr 140,000 and 85,000 and are present on a secreted protein, gp155.
L, Lefrancois, L, Puddington, C E, Machamer, M J, Bevan   +3 more
openaire   +2 more sources

Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development. [PDF]

PLoS ONE, 2008
OBF1, also known as Bob.1 or OCA-B, is a B lymphocyte-specific transcription factor which coactivates Oct1 and Oct2 on B cell specific promoters. So far, the function of OBF1 has been mainly identified in late stage B cell populations. The central defect
Alain Bordon, Nabil Bosco, Camille Du Roure, Boris Bartholdy, Hubertus Kohler, Gabriele Matthias, Antonius G Rolink, Patrick Matthias   +7 more
doaj   +1 more source

Generation and Characterization of a Murine Monoclonal Antibody Specific for the Human T1-Cd5 Molecule

The International Journal of Biological Markers, 1987
Murine monoclonal antibodies (MoAbs) have found widespread applications in the characterization of the molecular and functional features of lymphocyte differentiation antigens.
Federico Genzano, Ada Funaro, Massimo Alessio, Lucia B. De Monte, Graziella Bellone, Licia Peruzzi, Manuela Zaccolo, Federico Caligari-Cappino, Fabio Malavasi   +8 more
doaj   +1 more source

Production of Abzymes in Th, CBA, and C57BL/6 Mice before and after MOG Treatment: Comparing Changes in Cell Differentiation and Proliferation

Biomolecules, 2019
Till yet there is no data concerning mechanisms of autoimmune diseases development. Experimental autoimmune encephalomyelitis (EAE) prone C57BL/6 (T- and B-lymphocyte response), non-autoimmune CBA, and Th mice with T cell response were immunized with ...
Kseniya S. Aulova, Andrey E. Urusov, Ludmila B. Toporkova, Sergey E. Sedykh, Yuliya A. Shevchenko, Valery P. Tereshchenko, Sergei V. Sennikov, Thomas Budde, Sven G. Meuth, Nelly A. Popova, Irina A. Orlovskaya, Georgy A. Nevinsky   +11 more
doaj   +1 more source

CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen:Implications for parasite strain-specific immunity [PDF]

, 2009
Although immunodominance of CD8(+) T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear.
Connelley, T., Burrells, A, W. Ivan Morrison, Declan J. McKeever, Connelley, Timothy, Taracha, Evans L., Connelly, T, McKeever, DJ, Morrison, WI, Simon P. Graham, Burrells, A., MacHugh, ND, McKeever, D J, Taracha, E.L.N., Niall D. MacHugh, Roger Pelle, Ellis, SA, McKeever, Declan J., MacHugh, N D, Connelley, T, Evans L. Taracha, Ellis, S A, Graham, SP, Pelle, Roger, Ellis, Shirley A., MacHugh, Niall D., Formisano, Principia, Formisano, P, Principia Formisano, Taracha, EL, Ellis, S.A., Shirley A. Ellis, Taracha, E L, Alison Burrells, Pelle, R, Graham, Simon P., Graham, S P, Timothy Connelley, Formisano, P., Morrison, W. Ivan, Burrells, Alison, Graham, S.P.   +41 more
core   +1 more source

New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function

Journal of Biomedical Science, 2017
B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the development and function of antibody-producing B cells. Given that its function in T lymphocytes has been identified within the past decade, we review recent findings
Shin-Huei Fu, Li-Tzu Yeh, Chin-Chen Chu, B. Lin-Ju Yen, Huey-Kang Sytwu   +4 more
doaj   +1 more source

Cluster of differentiation antigens: essential roles in the identification of teleost fish T lymphocytes

Marine Life Science & Technology, 2022
AbstractCluster of differentiation (CD) antigens are cell surface molecules expressed on leukocytes and other cells associated with the immune system. Antibodies that react with CD antigens are known to be one of the most essential tools for identifying leukocyte subpopulations.
Tian, Hong-fei, Xing, Jing, Tang, Xiao-qian, Chi, Heng, Sheng, Xiu-zhen, Zhan, Wen-bin   +5 more
openaire   +2 more sources

Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6 [PDF]

, 2000
Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in germinal centers where terminal differentiation is delayed while somatic hypermutation creates high-affinity antibody mutants. Here we investigate whether
Peakman, LJ, Rajko Reljic (406091), Rajko Reljic, Reljic, R, Fearon, DT, Simon D. Wagner, Luke J. Peakman, Luke J. Peakman (7768292), Fearon, D T, Douglas T. Fearon, Wagner, S D, Wagner, SD, Simon D. Wagner (7633943), Douglas T. Fearon (7768295), Peakman, L J   +14 more
core   +1 more source