Results 11 to 20 of about 101,429 (314)
Expression of the CD6 T lymphocyte differentiation antigen in normal human brain [PDF]
Journal of Neuroimmunology, 1990 Antigens shared by the immune and central nervous systems (CNS) have been described repeatedly.The present study reports the expression of the CD6 lymphocyte differentiation antigen in normal humanbrain evidenced by immunohistochemistry and Northern blot analysis.
Mayer, Barbara +4 more
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The Effect of Immunosuppressive Adjuvant Kynurenine on Type 1 Diabetes Vaccine
Frontiers in Immunology, 2021 Inducing antigen-specific tolerance is a promising treatment for preventing or reversing Type 1 diabetes (T1D). In contrast to a vaccine that induces immune responses against pathogens, a tolerogenic vaccine can suppress immunity against antigens causing
Jing Sun +12 more
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The role of immune checkpoints in cardiovascular disease
Frontiers in Pharmacology, 2022 Immune checkpoint inhibitors (ICI) are monoclonal antibodies which bind to immune checkpoints (IC) and their ligands to prevent inhibition of T-cell activation by tumor cells.
Laura I. Yousif +4 more
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Assessing in vitro and in vivo Trogocytosis By Murine CD4+ T cells
Bio-Protocol, 2020 Recognition of antigens by lymphocytes (B, T, and NK) on the surface of an antigen-presenting cell (APC) leads to lymphocyte activation and the formation of an immunological synapse between the lymphocyte and the APC.
Jim Reed, Scott Wetzel
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Frontiers in Immunology, 2022 BackgroundThe Human Cell Differentiation Molecules (HCDM) organizes Human Leukocyte Differentiation Antigen (HLDA) workshops to test and name clusters of antibodies that react with a specific antigen.
Daniela Kužílková +8 more
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Incomplete Cd8+ T Lymphocyte Differentiation as a Mechanism for Subdominant Cytotoxic T Lymphocyte Responses to a Viral Antigen [PDF]
The Journal of Experimental Medicine, 2000 CD8+ cytotoxic T lymphocytes (CTLs) recognize antigen in the context of major histocompatibility complex (MHC) class I molecules. Class I epitopes have been classified as dominant or subdominant depending on the magnitude of the CTL response to the epitope.
Spencer, Juliet V, Braciale, Thomas J
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Molecular Therapy: Oncolytics, 2021 Recently, oncolytic vaccinia viruses (VACVs) have shown their potential to provide for clinically effective cancer treatments. The reason for this clinical usefulness is not only the direct destruction of infected cancer cells but also activation of ...
Stephanie Riederer +5 more
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Genetic deletion of Mst1 alters T cell function and protects against autoimmunity. [PDF]
PLoS ONE, 2014 Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking.
Konstantin V Salojin +24 more
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The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells
Frontiers in Immunology, 2019 Adaptor proteins contribute to the selection, differentiation and activation of natural killer T (NKT) cells, an innate(-like) lymphocyte population endowed with powerful immunomodulatory properties.
Evelyn Gerth, Jochen Mattner
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Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development. [PDF]
PLoS ONE, 2008 OBF1, also known as Bob.1 or OCA-B, is a B lymphocyte-specific transcription factor which coactivates Oct1 and Oct2 on B cell specific promoters. So far, the function of OBF1 has been mainly identified in late stage B cell populations. The central defect
Alain Bordon +7 more
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