Results 31 to 40 of about 101,429 (314)

Measles Vaccines Designed for Enhanced CD8⁺ T Cell Activation

Viruses, 2020
Priming and activation of CD8+ T cell responses is crucial to achieve anti-viral and anti-tumor immunity. Live attenuated measles vaccine strains have been used successfully for immunization for decades and are currently investigated in trials of ...
Elena Busch, Kristina D. Kubon, Johanna K. M. Mayer, Gemma Pidelaserra-Martí, Jessica Albert, Birgit Hoyler, Johannes P. W. Heidbuechel, Kyle B. Stephenson, Brian D. Lichty, Wolfram Osen, Stefan B. Eichmüller, Dirk Jäger, Guy Ungerechts, Christine E. Engeland   +13 more
doaj   +1 more source

Immunological markers of arthroplasty failure

Медицинская иммунология, 2023
Periprosthetic joint infection still remains a clinical challenge since accurate definition of this condition and reliable laboratory markers have not been established yet.
O. V. Moskalets
doaj   +1 more source

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]

, 1993
We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Lane, P., T Brocker, McConnell, F., S Hubele, F McConnell, Padovan, E., P Lane, E Padovan, Lanzavecchia, A., Brocker, Thomas, A Lanzavecchia, Hubele, S.   +11 more
core   +1 more source

Probiotic bacteria prevent Salmonella – induced suppression of lymphoproliferation in mice by an immunomodulatory mechanism

BMC Microbiology, 2017
Background Salmonella enterica infections often exhibit a form of immune evasion. We previously observed that probiotic bacteria could prevent inhibition of lymphoproliferation and apoptosis responses of T cells associated with S.
R. Doug Wagner, Shemedia J. Johnson
doaj   +1 more source

A reengineered common chain cytokine augments CD8+ T cell–dependent immunotherapy

JCI Insight, 2022
Cytokine therapy is limited by undesirable off-target side effects as well as terminal differentiation and exhaustion of chronically stimulated T cells.
Anirban Banerjee, Dongge Li, Yizhan Guo, Zhongcheng Mei, Christine Lau, Kelly Chen, John Westwick, Jeffery B. Klauda, Adam Schrum, Eric R. Lazear, Alexander S. Krupnick   +10 more
doaj   +1 more source

Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles

Journal of Extracellular Vesicles, 2022
Tumour cells are characterized by having lost their differentiation state. They constitutively secrete small extracellular vesicles (sEV) called exosomes when they come from late endosomes.
Michel Record, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, Bruno Payré, Laure Perrin‐Cocon, Florence Bourgailh, Antonin Lamazière, Vincent Lotteau, Marc Poirot, Sandrine Silvente‐Poirot, Philippe de Medina   +14 more
doaj   +1 more source

Human dendritic cells activated via dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses.

PLoS ONE, 2010
BackgroundDendritic cells capture antigens through PRRs and modulate adaptive immune responses. The type of adaptive immune T cell response generated is dependent upon the type of PRR activated by the microbes.
Sudhanshu Agrawal, Sudhir Gupta, Anshu Agrawal   +2 more
doaj   +1 more source

HLA Variation and SARS-CoV-2 Specific Antibody Response

Viruses, 2023
Differences in SARS-CoV-2-specific immune responses have been observed between individuals following natural infection or vaccination. In addition to already known factors, such as age, sex, COVID-19 severity, comorbidity, vaccination status, hybrid ...
Dawit Wolday, Chun Yiu Jordan Fung, Gregory Morgan, Selina Casalino, Erika Frangione, Jennifer Taher, Jordan P. Lerner-Ellis   +6 more
doaj   +1 more source

Effect of abrupt weaning at housing on leukocyte distribution, functional activity of neutrophils, and acute phase protein response of beef calves [PDF]

, 2010
peer-reviewedBackground: Sixteen, spring-born, single suckled, castrated male calves of Limousin × Holstein-Friesian and Simmental × Holstein-Friesian dams respectively, were used to investigate the effect of weaning on total leukocyte and differential ...
Lynch EM, McGee, Mark, McGee, M., Lynch, Eilish M, S Doyle, Lynch, E.M., Doyle S, B Earley, M McGee, Doyle, Sean, McGee M, Earley, Bernadette, Earley B, EM Lynch, Earley, B.   +14 more
core   +1 more source

Modulation of T-lymphocyte differentiation antigens: potential relevance for multiple sclerosis. [PDF]

Proceedings of the National Academy of Sciences, 1982
Effects of the anti-T-cell monoclonal antibodies OKT3, OKT5, and OKT8 on T-cell surface properties and cell functions were evaluated. Incubation of mononuclear cells isolated from peripheral blood for 48 hr with each monoclonal antibody in the absence of complement resulted in modulation of their respective surface antigens; i.e., the number of cells ...
J, Antel, J J, Oger, S, Jackevicius, H H, Kuo, B G, Arnason   +4 more
openaire   +2 more sources