Results 31 to 40 of about 11,845,318 (301)

Modulation of T-lymphocyte differentiation antigens: potential relevance for multiple sclerosis. [PDF]

Proceedings of the National Academy of Sciences, 1982
Effects of the anti-T-cell monoclonal antibodies OKT3, OKT5, and OKT8 on T-cell surface properties and cell functions were evaluated. Incubation of mononuclear cells isolated from peripheral blood for 48 hr with each monoclonal antibody in the absence of complement resulted in modulation of their respective surface antigens; i.e., the number of cells ...
J, Antel, J J, Oger, S, Jackevicius, H H, Kuo, B G, Arnason   +4 more
openaire   +2 more sources

HLA Variation and SARS-CoV-2 Specific Antibody Response

Viruses, 2023
Differences in SARS-CoV-2-specific immune responses have been observed between individuals following natural infection or vaccination. In addition to already known factors, such as age, sex, COVID-19 severity, comorbidity, vaccination status, hybrid ...
Dawit Wolday, Chun Yiu Jordan Fung, Gregory Morgan, Selina Casalino, Erika Frangione, Jennifer Taher, Jordan P. Lerner-Ellis   +6 more
doaj   +1 more source

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells [PDF]

, 2012
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8 cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the control of glucose uptake and ...
Julia Rolf, Sinclair, Linda V., David K. Finlay, Andrey A. Panteleyev, Rolf, Julia, Okkenhaug, Klaus, Klaus Okkenhaug, Doreen A. Cantrell, Cantrell, Doreen A., Rosenzweig, Ella, Jens L. Hukelmann, Feijoo-Carnero, Carmen, Carmen Feijoo-Carnero, Panteleyev, Andrey A., Hukelmann, Jens L., Linda V. Sinclair, Finlay, David K., Ella Rosenzweig   +17 more
core   +2 more sources

Structure and function of T lymphocyte differentiation antigens

Trends in Genetics, 1986
Abstract In addition to the T cell reception for antigen, T lymphocytes express a variety of additional T cell-specific surface molecules which are involved in recognition, activation and function. The structure, evolutionary relationship and functions of four of these T cell differentiation antigens are discussed.
openaire   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of abrupt weaning at housing on leukocyte distribution, functional activity of neutrophils, and acute phase protein response of beef calves [PDF]

, 2010
peer-reviewedBackground: Sixteen, spring-born, single suckled, castrated male calves of Limousin × Holstein-Friesian and Simmental × Holstein-Friesian dams respectively, were used to investigate the effect of weaning on total leukocyte and differential ...
Lynch EM, McGee, Mark, McGee, M., Lynch, Eilish M, S Doyle, Lynch, E.M., Doyle S, B Earley, M McGee, Doyle, Sean, McGee M, Earley, Bernadette, Earley B, EM Lynch, Earley, B.   +14 more
core   +1 more source

CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity [PDF]

, 1987
We have shown in a murine model system for acute, lethal cytomegalovirus (CMV) disease in the immunocompromised natural host that control of virus multiplication in tissues, protection from virus-caused tissue destruction, and survival are mediated by ...
Reddehase, Matthias J., Münch, Konrad, Koszinowski, Ulrich H., Mutter, Wolfgang, Bühring, Hans-Jörg   +4 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Regulated progression of B lymphocyte differentiation from cultured fetal liver. [PDF]

, 1987
Lymphoid fetal liver cultures (LFLC) are long-term, nontransformed cultures of early B lymphoid lineage cells which appear developmentally blocked at the pre-B stage in vitro.
O N Witte, Witte, ON, K A Denis, Denis, KA, K Dorshkind, Dorshkind, K   +5 more
core   +1 more source