Results 11 to 20 of about 15,870,834 (185)

CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity [PDF]

Journal of Virology, 1987
We have shown in a murine model system for acute, lethal cytomegalovirus (CMV) disease in the immunocompromised natural host that control of virus multiplication in tissues, protection from virus-caused tissue destruction, and survival are mediated by virus-specific CD8+ CD4-T lymphocytes.
Reddehase, Matthias J., Mutter, Wolfgang, Münch, Konrad, Bühring, Hans-Jörg, Koszinowski, Ulrich H.   +4 more
core   +6 more sources

High level of EZH2 expression is linked to high density of CD8-positive T-lymphocytes and an aggressive phenotype in renal cell carcinoma [PDF]

World Journal of Urology, 2020
Abstract Purpose Enhancer of zeste homolog 2 (EZH2), the catalytic part of the Polycomb repressive complex 2 (PRC2), has a prognostic role in renal cell carcinoma (RCC) and was recently shown to modulate the immune response by reducing tumor cell immunogenicity.
Eichenauer, Till, Simmendinger, Luca, Fraune, Christoph, Mandelkow, Tim, Blessin, Niclas C., Kluth, Martina, Hube-Magg, Claudia, Möller, Katharina, Clauditz, Till, Weidemann, Sören, Dahlem, Roland, Fisch, Margit, Riechardt, Silke, Simon, Ronald, Sauter, Guido, Büscheck, Franziska, Rink, Michael   +16 more
openaire   +3 more sources

CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors [PDF]

, 1988
The ability of memory T lymphocytes derived from latently infected mice to control murine cytomegalovirus disease in the immunocompromised host was studied by adoptive transfer experiments. At a stage of pathogenesis when virus had already colonized target tissues, a therapeutic antiviral function could be ascribed to the CD8+ subset.
Reddehase, Matthias J., Jonjic, Stipan, Weiland, Frank, Mutter, Wolfgang, Koszinowski, Ulrich H.   +4 more
openaire   +3 more sources

Clinical Significance of Programmed Death Ligand‑1 and Intra-Tumoral CD8+ T Lymphocytes in Ovarian Carcinosarcoma.

PLoS ONE, 2017
Ovarian carcinosarcoma (OCS) accounts for high mortality and lacks effective therapeutic methods. So far, we lack reliable biomarkers capable of predicting the risk of aggressive course of the disease.
Jun Zhu, Hao Wen, Xingzhu Ju, Rui Bi, Wenjia Zuo, Xiaohua Wu   +5 more
doaj   +2 more sources

of A rare population of tumor antigen-specific CD4+CD8+ double-positive ιβ T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells

, 2019
of A rare population of tumor antigen-specific CD4+CD8+ double-positive ιβ T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T ...
Kunle Odunsi (122690), Richard Koya (6192584), Thinle Chodon (241903), Junko Matsuzaki (209854), Takemasa Tsuji (209850), Courtney Ryan (6192581)   +5 more
core   +10 more sources

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes [PDF]

, 1990
Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain
Pavic, Ivica, Rukavina, Danijel, Koszinowski, Ulrich H., Koszinowski, U H, Lucin, Pero, Rukavina, Daniel, Jonjic, Stipan   +6 more
core   +2 more sources

Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report

Case Reports in Oncology, 2021
Cutaneous T-cell lymphoma (CTCL) describes a group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin. Mycosis fungoides (MF) represents the most common type of CTCL and accounts for ∼60% of all primary
Monira Abdullah Alnasser, Nour Marwan AlKhawajah, Nada Ghazi AlQadri, Asem Mustafa Shadid, Fahad M. Alsaif   +4 more
doaj   +1 more source

Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19

Journal of Intensive Care, 2021
We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry.
Yumi Mitsuyama, Kazuma Yamakawa, Katsuhide Kayano, Miho Maruyama, Takeshi Wada, Satoshi Fujimi   +5 more
doaj   +1 more source

USE OF TCR Vβ2 REPERTOIRES TO DIFFERENTIATE CD8 T-CELL LYMPHOMAS FROM INFECTIOUS DISEASE REACTIVE LYMPHOCYTOSIS

Hematology, Transfusion and Cell Therapy, 2021
Introduction: Reactive lymphocytosis can be difficult to differentiate from clonal lymphocytosis, especially when it involves CD8 positive T-lymphocytes. Leukemias and lymphomas cause an increase in this population at the expense of replication of clonal
DC Oliveira, YC Schluga, JLP Justus, MP Beltrame, AP Azambuja   +4 more
doaj   +1 more source

Inflammatory and immune checkpoint markers are associated with the severity of aortic stenosisCentral MessagePerspective

JTCVS Open, 2021
Objective: Aortic stenosis (AS) is a disease characterized by narrowing of the aortic valve (AV) orifice. In relation to this disease, the purpose of this study was to elucidate the relationships among factors such as expression of programmed cell death ...
Bilguun Erkhem-Ochir, MD, Wataru Tatsuishi, MD, PhD, Takehiko Yokobori, MD, PhD, Tsukasa Ohno, MD, PhD, Kyohei Hatori, MD, PhD, Tadashi Handa, PhD, Tetsunari Oyama, MD, PhD, Ken Shirabe, MD, PhD, Hiroshi Saeki, MD, PhD, Tomonobu Abe, MD, PhD   +9 more
doaj   +1 more source