Results 11 to 20 of about 639,889 (305)

CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity [PDF]

Journal of Virology, 1987
We have shown in a murine model system for acute, lethal cytomegalovirus (CMV) disease in the immunocompromised natural host that control of virus multiplication in tissues, protection from virus-caused tissue destruction, and survival are mediated by virus-specific CD8+ CD4-T lymphocytes.
Reddehase, Matthias J., Mutter, Wolfgang, Münch, Konrad, Bühring, Hans-Jörg, Koszinowski, Ulrich H.   +4 more
openaire   +6 more sources

CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors [PDF]

, 1988
The ability of memory T lymphocytes derived from latently infected mice to control murine cytomegalovirus disease in the immunocompromised host was studied by adoptive transfer experiments. At a stage of pathogenesis when virus had already colonized target tissues, a therapeutic antiviral function could be ascribed to the CD8+ subset.
Reddehase, Matthias J., Jonjic, Stipan, Weiland, Frank, Mutter, Wolfgang, Koszinowski, Ulrich H.   +4 more
openaire   +4 more sources

T lymphocytes infiltrating advanced grades of cervical neoplasia. CD8-positive cells are recruited to invasion [PDF]

Cancer, 1995
Impaired cellular immunity appears to be a risk factor for progression of cervical neoplasia, but the immunobiology of neoplastic progression is poorly understood. The objective of this study was to characterize the subpopulations of T lymphocytes that infiltrate various grades of cervical neoplasia including metaplasia to invasive cancer in ...
R P, Edwards, K, Kuykendall, P, Crowley-Nowick, E E, Partridge, H M, Shingleton, J, Mestecky   +5 more
openaire   +2 more sources

Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report

Case Reports in Oncology, 2021
Cutaneous T-cell lymphoma (CTCL) describes a group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin. Mycosis fungoides (MF) represents the most common type of CTCL and accounts for ∼60% of all primary
Monira Abdullah Alnasser, Nour Marwan AlKhawajah, Nada Ghazi AlQadri, Asem Mustafa Shadid, Fahad M. Alsaif   +4 more
doaj   +1 more source

Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19

Journal of Intensive Care, 2021
We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry.
Yumi Mitsuyama, Kazuma Yamakawa, Katsuhide Kayano, Miho Maruyama, Takeshi Wada, Satoshi Fujimi   +5 more
doaj   +1 more source

USE OF TCR Vβ2 REPERTOIRES TO DIFFERENTIATE CD8 T-CELL LYMPHOMAS FROM INFECTIOUS DISEASE REACTIVE LYMPHOCYTOSIS

Hematology, Transfusion and Cell Therapy, 2021
Introduction: Reactive lymphocytosis can be difficult to differentiate from clonal lymphocytosis, especially when it involves CD8 positive T-lymphocytes. Leukemias and lymphomas cause an increase in this population at the expense of replication of clonal
DC Oliveira, YC Schluga, JLP Justus, MP Beltrame, AP Azambuja   +4 more
doaj   +1 more source

Inflammatory and immune checkpoint markers are associated with the severity of aortic stenosisCentral MessagePerspective

JTCVS Open, 2021
Objective: Aortic stenosis (AS) is a disease characterized by narrowing of the aortic valve (AV) orifice. In relation to this disease, the purpose of this study was to elucidate the relationships among factors such as expression of programmed cell death ...
Bilguun Erkhem-Ochir, MD, Wataru Tatsuishi, MD, PhD, Takehiko Yokobori, MD, PhD, Tsukasa Ohno, MD, PhD, Kyohei Hatori, MD, PhD, Tadashi Handa, PhD, Tetsunari Oyama, MD, PhD, Ken Shirabe, MD, PhD, Hiroshi Saeki, MD, PhD, Tomonobu Abe, MD, PhD   +9 more
doaj   +1 more source

Causes of T lymphocyte activation in HIV-infected patients coinfected with hepatitis C virus [PDF]

Терапевтический архив, 2016
Aim. To establish the causes of T lymphocyte activation in human immunodeficiency virus (HIV)-infected patients coinfected with hepatitis C (HCV) who are adherent to their antiretroviral therapy regimen and interferon untreated.
K V Shmagel, N G Shmagel, L B Korolevskaya, E V Saydakova, V A Chereshnev   +4 more
doaj   +1 more source

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes [PDF]

, 1990
Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain
Pavic, Ivica, Rukavina, Danijel, Koszinowski, Ulrich H., Koszinowski, U H, Lucin, Pero, Rukavina, Daniel, Jonjic, Stipan   +6 more
core   +1 more source

A Study on Tumor-Infiltrating Lymphocytes in Different Subtypes of Breast Cancer [PDF]

Journal of Biomedical & Clinical Research, 2021
The study aimed to investigate immune cell infiltration in different subtypes of breast cancer (BC). Retrospectively were selected 100 patients with primary BC, grouped into four molecular surrogate subtypes (Luminal A and Luminal B-like, HER2-positive ...
Polina Dimitrova, Savelina Popovska, Ivan Ivanov   +2 more
doaj   +3 more sources